Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign. (Q37701711)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24611715%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign (English)

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10 March 2020

4

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10 March 2020

author name string

Thomas Gaj

1

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10 March 2020

Shannon J Sirk

2

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10 March 2020

Ryan D Tingle

3

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10 March 2020

Mark C Wallen

5

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10 March 2020

Carlos F Barbas

6

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10 March 2020

language of work or name

English

0 references

publication date

20 March 2014

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Journal of the American Chemical Society

10 March 2020

published in

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10 March 2020

volume

136

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10 March 2020

issue

13

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10 March 2020

page(s)

5047-5056

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Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants.

10 March 2020

cites work

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23 August 2017

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Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs

23 August 2017

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Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase

23 August 2017

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Structural Basis for Catalytic Activation of a Serine Recombinase

23 August 2017

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23 August 2017

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Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase

23 August 2017

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23 August 2017

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23 August 2017

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Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

23 August 2017

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23 August 2017

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Computational redesign of endonuclease DNA binding and cleavage specificity

23 August 2017

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Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets

23 August 2017

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Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors

23 August 2017

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Highly efficient endogenous human gene correction using designed zinc-finger nucleases

23 August 2017

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Chimeric recombinases with designed DNA sequence recognition

23 August 2017

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Enhancing Gene Targeting with Designed Zinc Finger Nucleases

23 August 2017

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Diversity in the serine recombinases

23 August 2017

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Directed evolution of a recombinase for improved genomic integration at a native human sequence

23 August 2017

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23 August 2017

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23 August 2017

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Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

23 August 2017

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Altering dimerization specificity by changes in surface electrostatics

23 August 2017

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Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

23 August 2017

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Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library

23 August 2017

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Crystal structure of the site-specific recombinase gamma delta resolvase complexed with a 34 bp cleavage site

23 August 2017

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Evolution of variants of yeast site-specific recombinase Flp that utilize native genomic sequences as recombination target sites

23 August 2017

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An unbiased genome-wide analysis of zinc-finger nuclease specificity

6 September 2017

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A dual reporter screening system identifies the amino acid at position 82 in Flp site-specific recombinase as a determinant for target specificity

6 September 2017

1 reference

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Quantification of zinc finger nuclease-associated toxicity

6 September 2017

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Critical amino acid residues within the φC31 integrase DNA-binding domain affect recombination activities in mammalian cells.

14 September 2017

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Amplifying genetic logic gates

14 September 2017

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Synthetic circuits integrating logic and memory in living cells

14 September 2017

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Alteration of Cre recombinase site specificity by substrate-linked protein evolution.

14 September 2017

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Improved properties of FLP recombinase evolved by cycling mutagenesis

23 June 2018

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23 June 2018

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Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA.

1 September 2018

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Site-specific genomic integration produces therapeutic Factor IX levels in mice

1 September 2018

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12 December 2020

The crystal structure of the catalytic domain of the site-specific recombination enzyme gamma delta resolvase at 2.7 A resolution

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12 December 2020

Analysis of subunit interaction by introducing disulfide bonds at the dimerization domain of Hin recombinase

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12 December 2020

The Hin dimer interface is critical for Fis-mediated activation of the catalytic steps of site-specific DNA inversion

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12 December 2020

Identifiers

DOI

10.1021/JA4130059

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24611715%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24611715%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

24611715

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24611715%20AND%20SRC:MED&resulttype=core&format=json