Helminth-derived immunomodulators: can understanding the worm produce the pill? (Q37708009)

22 August 2017

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title

Helminth-derived immunomodulators: can understanding the worm produce the pill? (English)

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22 August 2017

William Harnett

1

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PubMed ID

20224568

22 August 2017

Margaret M Harnett

series ordinal

2

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PubMed ID

20224568

22 August 2017

language of work or name

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12 March 2010

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Nature Reviews Immunology

22 August 2017

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22 August 2017

10

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22 August 2017

278-284

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22 August 2017

4

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Worms and the treatment of inflammatory bowel disease: are molecules the answer?

22 August 2017

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Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62.

21 January 2018

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Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism.

21 January 2018

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A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62.

21 January 2018

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A helminth glycan induces APC maturation via alternative NF-kappa B activation independent of I kappa B alpha degradation

21 January 2018

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Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.

21 January 2018

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A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells.

21 January 2018

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The role of sphingosine kinase in a murine model of allergic asthma

21 January 2018

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Diphosphoryl lipid A from Rhodobacter sphaeroides blocks the binding and internalization of lipopolysaccharide in RAW 264.7 cells

21 January 2018

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TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effects

21 January 2018

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Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminth-specific Th2 responses.

21 January 2018

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Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence.

21 January 2018

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A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages

21 January 2018

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Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo

21 January 2018

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Double-stranded RNAs from the Helminth ParasiteSchistosomaActivate TLR3 in Dendritic Cells

21 January 2018

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Soil-transmitted helminth infections: updating the global picture

21 January 2018

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Interactions between helminth parasites and allergy

31 March 2020

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Chronic helminth infections induce immunomodulation: consequences and mechanisms

31 March 2020

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Infections and allergy - helminths, hygiene and host immune regulation

31 March 2020

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Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function

31 March 2020

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Protective immune mechanisms in helminth infection

31 March 2020

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The impact of infection on the incidence of autoimmune disease

31 March 2020

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Review series on helminths, immune modulation and the hygiene hypothesis: how might infection modulate the onset of type 1 diabetes?

31 March 2020

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Therapeutic immunomodulators from nematode parasites

31 March 2020

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Suppression of TH2-type allergic reactions by helminth infection.

31 March 2020

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Helminths and our immune system: friend or foe?

31 March 2020

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Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases?

31 March 2020

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Helminths as governors of immune-mediated inflammation

31 March 2020

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A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization

31 March 2020

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Modulation of host immune responses by helminth glycans

31 March 2020

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Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology

31 March 2020

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Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for Th1/Th2 polarization

31 March 2020

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Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes

31 March 2020

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Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.

31 March 2020

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Prevention of psoriasis-like lesions development in fsn/fsn mice by helminth glycans

31 March 2020

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Molecular basis of the differences in binding properties of the highly related C-type lectins DC-SIGN and L-SIGN to Lewis X trisaccharide and Schistosoma mansoni egg antigens

31 March 2020

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Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation

31 March 2020

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Schistosoma mansoni egg antigen-mediated modulation of Toll-like receptor (TLR)-induced activation occurs independently of TLR2, TLR4, and MyD88

31 March 2020

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Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product

31 March 2020

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Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62.

31 March 2020

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The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease

31 March 2020

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The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis

31 March 2020

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Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell response

31 March 2020

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Dissecting Ascaris glycosphingolipids for immunomodulatory moieties--the use of synthetic structural glycosphingolipid analogues.

31 March 2020

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Immunomodulatory properties of Ascaris suum glycosphingolipids - phosphorylcholine and non-phosphorylcholine-dependent effects

31 March 2020

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The Schistosoma mansoni protein Sm16/SmSLP/SmSPO-1 assembles into a nine-subunit oligomer with potential To inhibit Toll-like receptor signaling.

31 March 2020

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Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3.

31 March 2020

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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

31 March 2020

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Cooperation of Toll-like receptor signals in innate immune defence

31 March 2020

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

31 March 2020

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Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells.

31 March 2020

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Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses

31 March 2020

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Helminth antigens modulate TLR-initiated dendritic cell activation

31 March 2020

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Galectin-3 modulates immune and inflammatory responses during helminthic infection: impact of galectin-3 deficiency on the functions of dendritic cells

31 March 2020

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Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.

31 March 2020

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Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling

31 March 2020

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Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis.

31 March 2020

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Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo

31 March 2020

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Location, location, location: identifying the neighborhoods of LPS signaling.

31 March 2020

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

31 March 2020

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The journey of Toll-like receptors in the cell.

31 March 2020

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Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

31 March 2020

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Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin

31 March 2020

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Concepts in sumoylation: a decade on

31 March 2020

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The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells

31 March 2020

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Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites

31 March 2020

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Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression

31 March 2020

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E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury

31 March 2020

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Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b

31 March 2020

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Modulation of host immune responses by nematode cystatins

31 March 2020

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Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A

31 March 2020

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Molecules of parasites as immunomodulatory drugs

31 March 2020

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The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

31 March 2020

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MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.

31 March 2020

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Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses

31 March 2020

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Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity

31 March 2020

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The orchestra of Toll-like receptors and their potential role in frequently occurring rheumatic conditions

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2730

1 reference

22 August 2017

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PubMed ID

20224568