A histone deacetylase inhibitor improves hypothyroidism caused by a TRα1 mutant (Q37708375)

22 August 2017

A histone deacetylase inhibitor improves hypothyroidism caused by a TRα1 mutant (English)

1 reference

22 August 2017

Dong Wook Kim

1

1 reference

22 August 2017

Jeong Won Park

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2

1 reference

22 August 2017

Mark C Willingham

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3

1 reference

22 August 2017

Sheue-yann Cheng

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4

1 reference

22 August 2017

30 December 2013

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22 August 2017

Human Molecular Genetics

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22 August 2017

23

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22 August 2017

2651-2664

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22 August 2017

10

1 reference

describes a project that uses

22 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3990165/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α

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Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents

23 August 2017

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Histone deacetylases as targets for treatment of multiple diseases

23 August 2017

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23 August 2017

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Mechanisms of thyroid hormone action

23 August 2017

1 reference

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Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).

23 August 2017

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Steroid receptor coactivators 1, 2, and 3: critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy

23 August 2017

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A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer

23 August 2017

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Phase II study of vorinostat for treatment of relapsed or refractory indolent non-Hodgkin's lymphoma and mantle cell lymphoma

23 August 2017

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The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis

23 August 2017

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New insights into regulation of lipid metabolism by thyroid hormone

23 August 2017

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Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer

23 August 2017

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Distinct dysregulation of lipid metabolism by unliganded thyroid hormone receptor isoforms

23 August 2017

1 reference

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The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo

23 August 2017

1 reference

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HDAC family: What are the cancer relevant targets?

23 August 2017

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HDAC3: taking the SMRT-N-CoRrect road to repression

23 August 2017

1 reference

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Impaired adipogenesis caused by a mutated thyroid hormone alpha1 receptor

23 August 2017

1 reference

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Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

23 August 2017

1 reference

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Transcriptional control of adipocyte formation

23 August 2017

1 reference

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Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)

23 August 2017

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Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expression

23 August 2017

1 reference

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Isoform-dependent actions of thyroid hormone nuclear receptors: lessons from knockin mutant mice

23 August 2017

1 reference

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The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3

23 August 2017

1 reference

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Reading and function of a histone code involved in targeting corepressor complexes for repression

23 August 2017

1 reference

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An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis

23 August 2017

1 reference

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The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

23 August 2017

1 reference

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Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR

23 August 2017

1 reference

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A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice

23 August 2017

1 reference

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Multiple mechanisms for regulation of the transcriptional activity of thyroid hormone receptors

23 August 2017

1 reference

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The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3

23 August 2017

1 reference

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Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone

23 August 2017

1 reference

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Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3

23 August 2017

1 reference

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The histone deacetylase-3 complex contains nuclear receptor corepressors

23 August 2017

1 reference

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Familial syndrome combining deaf-mutism, stuppled epiphyses, goiter and abnormally high PBI: possible target organ refractoriness to thyroid hormone

23 August 2017

1 reference

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The c-erb-A gene encodes a thyroid hormone receptor

23 August 2017

1 reference

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The c-erb-A protein is a high-affinity receptor for thyroid hormone

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

White adipocytes: more than just fat depots.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

A conserved surface on the ligand binding domain of nuclear receptors for allosteric control

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

The syndromes of resistance to thyroid hormone

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

An adult female with resistance to thyroid hormone mediated by defective thyroid hormone receptor α.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

Clinical phenotype of a new type of thyroid hormone resistance caused by a mutation of the TRα1 receptor: consequences of LT4 treatment.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

A mutation in the thyroid hormone receptor alpha gene.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

Alterations in genomic profiles during tumor progression in a mouse model of follicular thyroid carcinoma.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

Structure of the growth hormone-encoding gene and its promoter in mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3990165

Histone hyperacetylation is associated with amelioration of experimental colitis in mice

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24381310

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clinical phenotype and mutant TRα1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24381310

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDT660

1 reference

22 August 2017

1 reference

22 August 2017

1 reference