Biological actions of artemisinin: insights from medicinal chemistry studies (Q37718555)

2 July 2019

4 references

4 November 2019

7 November 2019

28 May 2020

18 July 2021

Biological actions of artemisinin: insights from medicinal chemistry studies (English)

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2 July 2019

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4 November 2019

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7 November 2019

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18 July 2021

Jian Li

1

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2 July 2019

Bing Zhou

series ordinal

2

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2 July 2019

language of work or name

English

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publication date

8 March 2010

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2 July 2019

4 November 2019

7 November 2019

28 May 2020

18 July 2021

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2 July 2019

4 November 2019

7 November 2019

28 May 2020

18 July 2021

15

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2 July 2019

issue

3

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2 July 2019

page(s)

1378-1397

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2 July 2019

Creative Commons Attribution

copyright license

4 references

4 November 2019

7 November 2019

28 May 2020

18 July 2021

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Epidemiology. Lower malaria numbers reflect better estimates and a glimmer of hope

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12 December 2020

Identification of an antimalarial synthetic trioxolane drug development candidate

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12 December 2020

Artemisinin: mechanisms of action, resistance and toxicity

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12 December 2020

Molecular docking and 3-D-QSAR studies on the possible antimalarial mechanism of artemisinin analogues

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12 December 2020

Artemisinin Resistance in Plasmodium falciparum Malaria

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12 December 2020

The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

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12 December 2020

Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether

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12 December 2020

The chemotherapy of rodent malaria, XXXIX. Ultrastructural changes following treatment with artemisinine of Plasmodium berghei infection in mice, with observations of the localization of [3H]-dihydroartemisinine in P. falciparum in vitro

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12 December 2020

Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite

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12 December 2020

Acid catalyzed michael additions to artemisitene

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12 December 2020

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12 December 2020

Antiviral effect of artemisinin from Artemisia annua against a model member of the Flaviviridae family, the bovine viral diarrhoea virus (BVDV).

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12 December 2020

Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX

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12 December 2020

A medicinal chemistry perspective on artemisinin and related endoperoxides

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12 December 2020

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

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12 December 2020

The antimalarial drug artemisinin alkylates heme in infected mice

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12 December 2020

Induction and isolation of artemisinine-resistant mutants of Plasmodium falciparum.

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12 December 2020

Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model

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12 December 2020

Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum.

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12 December 2020

The chemotherapy of rodent malaria. XLVIII. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 1: Studies leading to the development of novel cis-fused cyclopenteno derivatives

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12 December 2020

Docking studies of structurally diverse antimalarial drugs targeting PfATP6: no correlation between in silico binding affinity and in vitro antimalarial activity.

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12 December 2020

Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies

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12 December 2020

Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number

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12 December 2020

Oral artemether for prevention of Schistosoma mansoni infection: randomised controlled trial

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12 December 2020

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

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12 December 2020

Recent advances in artemisinin production through heterologous expression

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12 December 2020

Morphologic effects of artemether on Plasmodium falciparum in Aotus trivirgatus.

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12 December 2020

Qinghaosu-induced changes in the morphology of Plasmodium inui.

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12 December 2020

Atovaquone in the treatment of Babesia microti infections in hamsters

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12 December 2020

Highly Antimalaria-Active Artemisinin Derivatives: Biological Activity Does Not Correlate with Chemical Reactivity

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12 December 2020

Hemoglobin metabolism in the malaria parasite Plasmodium falciparum

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12 December 2020

Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes

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12 December 2020

Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation

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12 December 2020

Artemisinins for schistosomiasis and beyond.

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12 December 2020

Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides

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12 December 2020

Antimalaria studies on Qinghaosu

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12 December 2020

Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells

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12 December 2020

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

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12 December 2020

A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

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12 December 2020

Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose

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12 December 2020

Antioxidant and free radical scavenging activities of the iron chelators pyoverdin and hydroxypyrid-4-ones in iron-loaded hepatocyte cultures: comparison of their mechanism of protection with that of desferrioxamine

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12 December 2020

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

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12 December 2020

The chemotherapy of rodent malaria. XLIX. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 2: Structure-activity studies on cis-fused cyclopenteno-1,2,4-trioxanes (fenozans) aga

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12 December 2020

Artesunate derived from traditional Chinese medicine induces DNA damage and repair.

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12 December 2020

Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.

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12 December 2020

Possible modes of action of the artemisinin-type compounds.

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12 December 2020

Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family

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12 December 2020

Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).

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12 December 2020

New developments in synthetic peroxidic drugs as artemisinin mimics

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12 December 2020

Artemisinin triggers induction of cell-cycle arrest and apoptosis in Leishmania donovani promastigotes

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12 December 2020

Effects of antimalarials and protease inhibitors on plasmodial hemozoin production

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12 December 2020

Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6.

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12 December 2020

Effects of mitochondrial inhibitors on intraerythrocytic Plasmodium falciparum in in vitro cultures.

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12 December 2020

Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

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12 December 2020

Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin

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12 December 2020

High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli

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12 December 2020

Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.

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12 December 2020

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12 December 2020

In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin

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12 December 2020

Alkylation of heme by the antimalarial drug artemisinin

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12 December 2020

Endoperoxides as potential antimalarial agents

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12 December 2020

Hemin-catalyzed decomposition of artemisinin (qinghaosu)

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12 December 2020

Iron chelators as drugs against malaria pose a potential risk.

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12 December 2020

Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin

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12 December 2020

The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates

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12 December 2020

Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology

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12 December 2020

Reaction of antimalarial endoperoxides with specific parasite proteins

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12 December 2020

Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression.

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12 December 2020

Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation.

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12 December 2020

A quantitative structure-activity study on artemisinine analogues (author's transl)

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12 December 2020

Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage.

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12 December 2020

Heme-artemisinin adducts are crucial mediators of the ability of artemisinin to inhibit heme polymerization

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12 December 2020

Homology modeling and molecular docking study of translationally controlled tumor protein and artemisinin

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12 December 2020

Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.

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12 December 2020

The interaction of artemisinin with malarial hemozoin.

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12 December 2020

Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria

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12 December 2020

Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds

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12 December 2020

The mode of action of the antimalarial artemisinin and its derivatives

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12 December 2020

Qinghaosu, dietary vitamin E, selenium, and cod-liver oil: effect on the susceptibility of mice to the malarial parasite Plasmodium yoelii.

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12 December 2020

The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenes

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12 December 2020

Yeast model uncovers dual roles of mitochondria in action of artemisinin

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12 December 2020

Artemisinins target the SERCA of Plasmodium falciparum

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12 December 2020

The chemotherapy of rodent malaria. LVI. Studies on the development of resistance to natural and synthetic endoperoxides

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12 December 2020

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

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12 December 2020

Interaction of artemisinins with oxyhemoglobin Hb-FeII, Hb-FeII, carboxyHb-FeII, heme-FeII, and carboxyheme FeII: significance for mode of action and implications for therapy of cerebral malaria

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12 December 2020

Morphologic effects of artemisinin in Plasmodium falciparum

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12 December 2020

Reaction of artemisinin with haemoglobin: implications for antimalarial activity

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12 December 2020

Resistance to dihydroartemisinin

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12 December 2020

Three-dimensional structure of Plasmodium falciparum Ca2+ -ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6.

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12 December 2020

Activated oxygen mediates the antimalarial activity of qinghaosu.

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12 December 2020

Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia

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12 December 2020

Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins

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12 December 2020

Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1.

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12 December 2020

Artemisinin-resistant malaria in Asia.

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12 December 2020

Redox reaction of artemisinin with ferrous and ferric ions in aqueous buffer

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12 December 2020

Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine.

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12 December 2020

Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action

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12 December 2020

10.3390/MOLECULES15031378

Identifiers

DOI

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2 July 2019

PMCID

6257283

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2 July 2019

PubMed ID

20335987

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2 July 2019