Langerhans cells: critical regulators of skin immunity? (Q37721150)

22 August 2017

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title

Langerhans cells: critical regulators of skin immunity? (English)

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22 August 2017

Björn E Clausen

1

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22 August 2017

Junda M Kel

series ordinal

2

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22 August 2017

publication date

30 March 2010

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Immunology & Cell Biology

22 August 2017

published in

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22 August 2017

volume

88

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22 August 2017

issue

4

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22 August 2017

page(s)

351-360

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Tolerogenic dendritic cells

22 August 2017

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Developmental regulation of MHC class II transport in mouse dendritic cells.

21 January 2018

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Epidermal Langerhans cells are derived from cells originating in bone marrow

21 January 2018

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Mouse epidermal Ia molecules have a bone marrow origin

21 January 2018

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Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli.

21 January 2018

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External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

21 January 2018

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Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

21 January 2018

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Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin.

21 January 2018

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Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo

21 January 2018

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The induction of tolerance by dendritic cells that have captured apoptotic cells

21 January 2018

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A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes

21 January 2018

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A close-up view of migrating Langerhans cells in the skin.

21 January 2018

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Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells.

21 January 2018

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Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo

21 January 2018

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Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance

21 January 2018

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Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance

21 January 2018

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Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation

21 January 2018

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Most lymphoid organ dendritic cell types are phenotypically and functionally immature.

21 January 2018

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Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells

21 January 2018

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Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

Skin-derived dendritic cells induce potent CD8(+) T cell immunity in recombinant lentivector-mediated genetic immunization

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

CD8 alpha- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

Priming of CD8+ and CD4+ T cells in experimental leishmaniasis is initiated by different dendritic cell subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

Division of labor, plasticity, and crosstalk between dendritic cell subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Langerin is a natural barrier to HIV-1 transmission by Langerhans cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Identification and expression of mouse Langerin (CD207) in dendritic cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

DC ablation in mice: promises, pitfalls, and challenges

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.40

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Conditional gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Identification of a novel population of Langerin+ dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Insights into Langerhans cell function from Langerhans cell ablation models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

High and low doses of haptens dictate whether dermal or epidermal antigen-presenting cells promote contact hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Tumor immunotherapy by epicutaneous immunization requires langerhans cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Langerhans cells are not required for efficient skin graft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Sunlight and skin cancer: another link revealed

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Langerhans cells are required for UVR-induced immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Epidermal Langerhans cells are not required for UV-induced immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

DNA repair and cytokine responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Transforming growth factor-beta regulation of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Transcriptional profiling identifies Id2 function in dendritic cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Interleukin-10 and the interleukin-10 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Interleukin-10-deficient mice develop chronic enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

Epidermal cell-induced generation of cytotoxic T-lymphocyte responses against alloantigens or TNP-modified syngeneic cells: requirement for Ia-positive Langerhans cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Migratory dendritic cells: sometimes simply ferries?

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Murine epidermal Langerhans cells are potent stimulators of an antigen-specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice

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https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Structure-function analysis of the diphtheria toxin receptor toxin binding site by site-directed mutagenesis

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https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Langerhans cells are required for efficient presentation of topically applied hapten to T cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Langerhans cells at the interface of medicine, science, and industry

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Migratory Langerhans cells in mouse lymph nodes in steady state and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Ultraviolet light depletes surface markers of Langerhans cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Alteration of the migratory behavior of UV-induced regulatory T cells by tissue-specific dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

TGFbeta-dependent gene expression profile during maturation of dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Cutting edge: in vitro-generated tolerogenic APC induce CD8+ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Appearance of Langerhans cells in the epidermis of Tgfb1(-/-) SCID mice: paracrine and autocrine effects of transforming growth factor-beta 1 and -beta 2(1)

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Interleukin-10-treated dendritic cells modulate immune responses of naive and sensitized T cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

"Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.40

7 January 2021

Identifiers

DOI

10.1038/ICB.2010.40

1 reference

Dimensions Publication ID

22 August 2017

1010485004

0 references

1 reference