Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity (Q37734538)

22 August 2017

Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity (English)

1 reference

22 August 2017

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1 reference

Ginger E Dutschman

1

1 reference

22 August 2017

Susan P Grill

2

1 reference

22 August 2017

Elizabeth A Gullen

3

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22 August 2017

Kazuhiro Haraguchi

4

1 reference

22 August 2017

Shingo Takeda

5

1 reference

22 August 2017

Hiromichi Tanaka

6

1 reference

22 August 2017

Masanori Baba

7

1 reference

22 August 2017

Yung-Chi Cheng

8

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22 August 2017

language of work or name

English

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publication date

1 May 2004

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Antimicrobial Agents and Chemotherapy

22 August 2017

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22 August 2017

48

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22 August 2017

5

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22 August 2017

1640-1646

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describes a project that uses

22 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC400579/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors

22 August 2017

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22 August 2017

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Metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus beta-D(+) nucleoside analogs in vitro

22 August 2017

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Comparison of dihydropyrimidine dehydrogenase from human, rat, pig and cow liver. Biochemical and immunological properties

22 August 2017

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22 August 2017

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22 August 2017

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Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides

22 August 2017

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22 August 2017

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The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

22 August 2017

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Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus

22 August 2017

1 reference

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Nature, time course and dose dependence of zidovudine-related side effects: results from the Multicenter Canadian Azidothymidine Trial

22 August 2017

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Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus

22 August 2017

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Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay

22 August 2017

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Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity

22 August 2017

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Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues

22 August 2017

1 reference

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The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro

22 August 2017

1 reference

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Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides

22 August 2017

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(-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro

22 August 2017

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In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase

22 August 2017

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Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes

22 August 2017

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Human deoxythymidine kinase. I. Purification and general properties of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia

22 August 2017

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Mitochondrial toxicity of antiviral drugs

22 August 2017

1 reference

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Thymidine kinase from blast cells of myelocytic leukemia

14 September 2017

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Viral resistance and the selection of antiretroviral combinations

14 September 2017

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Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of

28 September 2017

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Favorable interaction of beta-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus

23 June 2018

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Synthesis and biological evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides as potential antiviral agents against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).

23 June 2018

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2',3'-didehydro-3'-deoxythymidine (d4T) in patients with AIDS or AIDS-related complex: a phase I trial

23 June 2018

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Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro

23 June 2018

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Initial studies on the cellular pharmacology of 3'-deoxythymidin-2'-ene (d4T): a potent and selective inhibitor of human immunodeficiency virus

23 June 2018

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Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine

23 June 2018

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Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine

23 June 2018

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Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400579

Antiviral activity of 2',3'-dideoxy-beta-L-5-fluorocytidine (beta-L-FddC) and 2',3'-dideoxy-beta-L-cytidine (beta-L-ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro

1 September 2018

1 reference

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Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15105115

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15105115

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.48.5.1640-1646.2004

1 reference

22 August 2017

1 reference

22 August 2017

PubMed publication ID

15105115

1 reference