Epigenetics of ovarian cancer: from the lab to the clinic (Q37737449)

22 August 2017

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title

Epigenetics of ovarian cancer: from the lab to the clinic (English)

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22 August 2017

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Reza Asadollahi

1

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22 August 2017

Caroline A C Hyde

series ordinal

2

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22 August 2017

Xiao Yan Zhong

series ordinal

3

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22 August 2017

language of work or name

English

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publication date

24 April 2010

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22 August 2017

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22 August 2017

118

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22 August 2017

81-87

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22 August 2017

1

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22 August 2017

Cancer statistics, 2009

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Optimal chemotherapy treatment for women with recurrent ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

The biology of ovarian cancer: new opportunities for translation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Minireview: epigenetic changes in ovarian cancer.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

S-Adenosylmethionine and methylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Imprinted genes as potential genetic and epigenetic toxicologic targets

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Number of CpG islands and genes in human and mouse

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

DNA methylation analysis: a powerful new tool for lung cancer diagnosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

DNA methylation changes in ovarian cancer: implications for early diagnosis, prognosis and treatment

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

CpG Island Methylation of DNA Damage Response Genes in Advanced Ovarian Cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Epigenetic regulation of ARHI in breast and ovarian cancer cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

p16/MTS1 inactivation in ovarian carcinomas: high frequency of reduced protein expression associated with hyper-methylation or mutation in endometrioid and mucinous tumors

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

The epigenetics of ovarian cancer drug resistance and resensitization

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

High-resolution methylation analysis of the BRCA1 promoter in ovarian tumors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Promoter methylation status and expression of TMS1 gene in human epithelial ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Epigenetic inactivation of TMS1/ASC in ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

WT1 and WT1-AS genes are inactivated by promoter methylation in ovarian clear cell adenocarcinoma.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Promoter hypermethylation profile of ovarian epithelial neoplasms

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Epigenetic regulation of maspin expression in human ovarian carcinoma cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

The power and the promise of DNA methylation markers

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Tumor Cell-SpecificBRCA1andRASSF1AHypermethylation in Serum, Plasma, and Peritoneal Fluid from Ovarian Cancer Patients

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

An epigenetic marker panel for screening and prognostic prediction of ovarian cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Predictive utility of circulating methylated DNA in serum of melanoma patients receiving biochemotherapy.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

An epigenetic signature in peripheral blood predicts active ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

CpG island methylator phenotype in colorectal cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

DNA methylation and environmental exposures in human hepatocellular carcinoma

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

CpG island methylator phenotype redefines the prognostic effect of t(12;21) in childhood acute lymphoblastic leukemia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

CpG island methylator phenotype predicts progression of malignant melanoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

CpG island methylator phenotype (CIMP) in cancer: causes and implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Reading signals on the nucleosome with a new nomenclature for modified histones

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Translating the Histone Code

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Active genes are tri-methylated at K4 of histone H3

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Dominant-negative histone H3 lysine 27 mutant derepresses silenced tumor suppressor genes and reverses the drug-resistant phenotype in cancer cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

E2F Family Members Are Differentially Regulated by Reversible Acetylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Acetylated sp3 is a transcriptional activator

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Expression profile of histone deacetylases 1, 2 and 3 in ovarian cancer tissues

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Regulation of the CLDN3 gene in ovarian cancer cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Histone modifications silence the GATA transcription factor genes in ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

MicroRNA biogenesis and cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Control of translation and mRNA degradation by miRNAs and siRNAs

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

MicroRNA signatures in human ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Frequent downregulation of miR-34 family in human ovarian cancers

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Serum and tissue biomarkers as predictive and prognostic variables in epithelial ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Prognostic DNA methylation biomarkers in ovarian cancer.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Utility of gene promoter methylation in prediction of response to platinum-based chemotherapy in epithelial ovarian cancer (EOC)

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

MicroRNAs and their target messenger RNAs associated with ovarian cancer response to chemotherapy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Small RNAs are raising big expectations

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

The epigenomics of cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

7 January 2021

Epigenetics in cancer

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Epigenetic therapies for chemoresensitization of epithelial ovarian cancer.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

New anti-cancer strategies: epigenetic therapies and biomarkers

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

DNA methyltransferase inhibitors and the development of epigenetic cancer therapies

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Methylation profile in benign, borderline and malignant ovarian tumors.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Loss of estrogen receptor beta isoform expression and its correlation with aberrant DNA methylation of the 5'-untranslated region in human epithelial ovarian carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Methylation of tumor suppressor gene p16 and prognosis of epithelial ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Collagen and calcium-binding EGF domains 1 is frequently inactivated in ovarian cancer by aberrant promoter hypermethylation and modulates cell migration and survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

RUNX3 gene methylation in epithelial ovarian cancer tissues and ovarian cancer cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

CHFR promoter hypermethylation and reduced CHFR mRNA expression in ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

Identification of aberrant promoter hypomethylation of HOXA10 in ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2010.03.015

10.1016/J.YGYNO.2010.03.015

7 January 2021

Identifiers

DOI

1 reference

22 August 2017

1 reference