Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use. (Q37738742)

22 August 2017

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use. (English)

1 reference

22 August 2017

0 references

6

1 reference

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10 June 2020

Dominic De Nardo

8

1 reference

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10 June 2020

Veit Hornung

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10 June 2020

15

Iain D C Fraser

1 reference

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10 June 2020

author name string

Jing Sun

1

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10 June 2020

Ning Li

2

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10 June 2020

Kyu-Seon Oh

3

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10 June 2020

Bhaskar Dutta

4

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10 June 2020

Sharat J Vayttaden

5

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10 June 2020

Thomas S Ebert

7

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10 June 2020

Joie Davis

9

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10 June 2020

Rustam Bagirzadeh

10

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10 June 2020

Nicolas W Lounsbury

11

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10 June 2020

Chandrashekhar Pasare

12

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10 June 2020

Eicke Latz

13

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10 June 2020

language of work or name

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5 January 2016

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22 August 2017

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10 June 2020

volume

9

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10 June 2020

issue

409

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10 June 2020

page(s)

ra3

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Development of a cell system for siRNA screening of pathogen responses in human and mouse macrophages

10 June 2020

cites work

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Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-κB signaling

22 August 2017

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IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation.

22 August 2017

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Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages.

22 August 2017

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Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

22 August 2017

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Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.

22 August 2017

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Genomic responses in mouse models poorly mimic human inflammatory diseases

22 August 2017

1 reference

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Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

22 August 2017

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IRAK1 rs3027898 C/A polymorphism is associated with risk of rheumatoid arthritis.

22 August 2017

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Common seed analysis to identify off-target effects in siRNA screens

22 August 2017

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Systematic discovery of TLR signaling components delineates viral-sensing circuits

22 August 2017

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Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IκBα deficiency

22 August 2017

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Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha

22 August 2017

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The inflammasome NLRs in immunity, inflammation, and associated diseases

22 August 2017

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Pattern recognition receptors and inflammation

22 August 2017

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Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses

22 August 2017

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Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105

22 August 2017

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Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

22 August 2017

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The roles of TLRs, RLRs and NLRs in pathogen recognition

22 August 2017

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Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.

22 August 2017

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Gene-specific control of the TLR-induced inflammatory response

22 August 2017

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The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation

22 August 2017

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22 August 2017

TLRs and innate immunity

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The art and design of genetic screens: RNA interference.

22 August 2017

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Forward genetic analysis of TLR-signaling pathways: an evaluation

22 August 2017

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Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

22 August 2017

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Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

22 August 2017

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Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis

22 August 2017

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Pathogen recognition and innate immunity

22 August 2017

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The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

22 August 2017

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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

22 August 2017

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

22 August 2017

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Pyogenic bacterial infections in humans with IRAK-4 deficiency

22 August 2017

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Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

22 August 2017

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Distinct molecular mechanism for initiating TRAF6 signalling

22 August 2017

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Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

22 August 2017

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

22 August 2017

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

22 August 2017

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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

22 August 2017

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Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

22 August 2017

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

22 August 2017

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IRAK: a kinase associated with the interleukin-1 receptor

22 August 2017

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Deciphering the complexity of Toll-like receptor signaling

22 August 2017

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22 August 2017

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A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide

6 September 2017

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Innate immune sensing and signaling of cytosolic nucleic acids

6 September 2017

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Nucleic acid recognition by the innate immune system

6 September 2017

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An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.

6 September 2017

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Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

14 September 2017

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IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness

14 September 2017

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TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

14 September 2017

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Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome

14 September 2017

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Developmental and tissue-specific expression of mouse pelle-like protein kinase

23 June 2018

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Immune complex-mediated cell activation from systemic lupus erythematosus and rheumatoid arthritis patients elaborate different requirements for IRAK1/4 kinase activity across human cell types

23 June 2018

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1 September 2018

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A probability-based approach for the analysis of large-scale RNAi screens.

1 September 2018

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IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity

1 September 2018

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IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

1 September 2018

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Genomic responses in mouse models greatly mimic human inflammatory diseases

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2191

Gene Expression Analysis in Blood Cells in Response to Unmodified and 2′-Modified siRNAs Reveals TLR-dependent and Independent Effects

21 January 2018

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Down-regulation of IRAK-4 is a component of LPS- and CpG DNA-induced tolerance in macrophages

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26732763

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26732763

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26732763

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCISIGNAL.AAB2191

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26732763%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26732763%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

26732763

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26732763%20AND%20SRC:MED&resulttype=core&format=json