Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease--therapeutic aspects (Q37749683)

22 August 2017

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title

Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease--therapeutic aspects (English)

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22 August 2017

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Anne Eckert

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author name string

Walter E Müller

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22 August 2017

Christopher Kurz

3

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22 August 2017

Gunter Peter Eckert

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22 August 2017

Kristina Leuner

5

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22 August 2017

12 May 2010

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22 August 2017

Molecular Neurobiology

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22 August 2017

41

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22 August 2017

159-171

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22 August 2017

2-3

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https://scigraph.springernature.com/pub.10.1007/s12035-010-8141-5

22 August 2017

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Evidence of increased oxidative damage in subjects with mild cognitive impairment.

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Neuronal degeneration and mitochondrial dysfunction

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Ginkgo biloba extract (EGb 761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse.

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Piracetam improves mitochondrial dysfunction following oxidative stress

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The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by beta-amyloid peptide

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Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761

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Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.

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Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implication

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Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans.

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Brain Cytochrome Oxidase in Alzheimer's Disease

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Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage.

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S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury

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12 December 2020

A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress.

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12 December 2020

Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice

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Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein

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12 December 2020

Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment.

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12 December 2020

Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients

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12 December 2020

Involvement of oxidative stress in Alzheimer disease

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12 December 2020

Promotion of oxidative lipid membrane damage by amyloid beta proteins

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12 December 2020

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease.

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12 December 2020

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

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12 December 2020

Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders

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12 December 2020

Vitamin C and Vitamin E for Alzheimer's Disease

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Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

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Presenilin-dependent gamma-secretase activity modulates neurite outgrowth

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Piracetam and TRH analogues antagonise inhibition by barbiturates, diazepam, melatonin and galanin of human erythrocyte D-glucose transport.

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A novel neurotrophic agent, T-817MA [1-{3-[2-(1-benzothiophen-5-yl) ethoxy] propyl}-3-azetidinol maleate], attenuates amyloid-beta-induced neurotoxicity and promotes neurite outgrowth in rat cultured central nervous system neurons

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12 December 2020

Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease

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12 December 2020

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

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12 December 2020

The antioxidant activity of standardized extract of Ginkgo biloba (EGb 761) in rats.

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12 December 2020

ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain

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12 December 2020

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12 December 2020

Methylene blue restores spatial memory retention impaired by an inhibitor of cytochrome oxidase in rats.

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12 December 2020

Mitochondria, oxidants, and aging

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12 December 2020

Oxidative damage in Alzheimer's disease: the metabolic dimension

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12 December 2020

Piracetam: novelty in a unique mode of action

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12 December 2020

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

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12 December 2020

Hope in Alzheimer's fight emerges from unexpected places.

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12 December 2020

Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration.

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12 December 2020

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

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12 December 2020

Flavonoids and the aging brain.

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12 December 2020

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.

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12 December 2020

Mediterranean diet and risk for Alzheimer's disease

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12 December 2020

Gradual alteration of mitochondrial structure and function by beta-amyloids: importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release

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12 December 2020

Hormesis and disease resistance: activation of cellular stress response pathways

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12 December 2020

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

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12 December 2020

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

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12 December 2020

Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis

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12 December 2020

Mitochondrial dysfunction induced by disease relevant AbetaPP and tau protein mutations.

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12 December 2020

Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations

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12 December 2020

Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease

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12 December 2020

Abeta(1-42) reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: a quantitative analysis

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12 December 2020

Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease

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12 December 2020

Mitochondria in neuroplasticity and neurological disorders

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12 December 2020

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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12 December 2020

Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo

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12 December 2020

Influence of aging and exogenous substances on cerebral energy metabolism in posthypoglycemic recovery.

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12 December 2020

Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease

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12 December 2020

Dietary factors, hormesis and health

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12 December 2020

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway

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12 December 2020

Mitochondrial complex I defects in aging.

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12 December 2020

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

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12 December 2020

Pathways towards and away from Alzheimer's disease

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12 December 2020

Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease

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12 December 2020

Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice.

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12 December 2020

Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

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12 December 2020

Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease.

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12 December 2020

Cortical cytochrome oxidase activity is reduced in Alzheimer's disease.

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12 December 2020

Tau filament formation in transgenic mice expressing P301L tau.

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12 December 2020

Enhanced ROS-generation in lymphocytes from Alzheimer's patients

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12 December 2020

Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice

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12 December 2020

Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis

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12 December 2020

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha

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12 December 2020

Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761

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12 December 2020

Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD.

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12 December 2020

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

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12 December 2020

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

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12 December 2020

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

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12 December 2020

Oxidative stress and neurodegeneration: where are we now?

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12 December 2020

Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics

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12 December 2020

The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

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12 December 2020

Regulation and pharmacology of the mitochondrial permeability transition pore

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12 December 2020

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

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12 December 2020

Protection by bilobalide of the ischaemia-induced alterations of the mitochondrial respiratory activity.

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12 December 2020

Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model.

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12 December 2020

Methylene blue improves brain oxidative metabolism and memory retention in rats.

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12 December 2020

Plant derived omega-3-fatty acids protect mitochondrial function in the brain

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12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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12 December 2020

Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease?

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12 December 2020

Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways

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12 December 2020

Mutations of the presenilin I gene in families with early-onset Alzheimer's disease

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12 December 2020

The action of piracetam on 14C-glucose metabolism in normal and posthypoxic rat cerebral cortex slices

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12 December 2020

Alzheimer's disease: a lesson from mitochondrial dysfunction.

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12 December 2020

Ginkgo biloba extract: from molecular mechanisms to the treatment of Alzhelmer's disease

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12 December 2020

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

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12 December 2020

Plant foods and brain aging: a critical appraisal

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12 December 2020

Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex

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12 December 2020

The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease

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12 December 2020

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

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12 December 2020

Ultrastructure evidence of necrotic neural cell death in familial Alzheimer's disease brains bearing presenilin-1 E280A mutation

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12 December 2020

Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation.

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12 December 2020

Mitochondrial abnormalities in Alzheimer's disease.

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12 December 2020

Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications

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12 December 2020

Mitochondrial dysfunction in aging and Alzheimer's disease: strategies to protect neurons

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12 December 2020

10.1007/S12035-010-8141-5

Identifiers

DOI

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22 August 2017

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