Calcitonin gene-related peptide receptor antagonists for migraine (Q37756158)

22 August 2017

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title

Calcitonin gene-related peptide receptor antagonists for migraine (English)

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22 August 2017

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Michael J M Fischer

1

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PubMed ID

20482328

22 August 2017

language of work or name

English

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publication date

1 July 2010

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Expert Opinion on Investigational Drugs

22 August 2017

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22 August 2017

19

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22 August 2017

7

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22 August 2017

815-823

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Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

22 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide is present in mammalian cerebrovascular nerve fibres and dilates pial and peripheral arteries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

CGRP, a vasodilator neuropeptide that stimulates neuromuscular transmission and EC coupling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

The signature sequence of voltage-gated potassium channels projects into the external vestibule

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Localization and modulation of calcitonin gene-related peptide-receptor component protein-immunoreactive cells in the rat central and peripheral nervous systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Desensitisation of adrenomedullin and CGRP receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide coexists with substance P in capsaicin sensitive neurons and sensory ganglia of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Coexistence of calcitonin gene-related peptide and substance P-like peptide in single cells of the trigeminal ganglion of the rat: immunohistochemical analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Innervation of the dura mater encephali of cat and rat: ultrastructure and calcitonin gene-related peptide-like and substance P-like immunoreactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Central projections of the sensory innervation of the rat middle meningeal artery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide release from intact isolated dorsal root and trigeminal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Regulation of calcitonin gene-related peptide release from rat trigeminal nucleus caudalis slices in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Nitric oxide releases calcitonin-gene-related peptide from rat dura mater encephali promoting increases in meningeal blood flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Glyceroltrinitrate facilitates stimulated CGRP release but not gene expression of CGRP or its receptor components in rat trigeminal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide is a potent inhibitor of substance P degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide enhances substance P-induced behaviors via metabolic inhibition: in vivo evidence for a new mechanism of neuromodulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide (CGRP) modulates nociceptive trigeminovascular transmission in the cat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Effects of prolonged infusion of human alpha calcitonin gene-related peptide on hemodynamics, renal blood flow and hormone levels in congestive heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

CGRP may play a causative role in migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Turn structures in CGRP C-terminal analogues promote stable arrangements of key residue side chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide-induced vasodilation in the human forearm is antagonized by CGRP8-37: evaluation of a human in vivo pharmacodynamic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: tailored-SELEX

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Effect of two novel CGRP-binding compounds in a closed cranial window rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-relate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

The discovery of highly potent CGRP receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Clinical pharmacology of the serotonin receptor agonist, zolmitriptan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Comparison of intravenous valproate with intravenous lysine-acetylsalicylic acid in acute migraine attacks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Neurogenic inflammation in the context of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

The nonpeptide calcitonin gene-related peptide receptor antagonist BIBN4096BS lowers the activity of neurons with meningeal input in the rat spinal trigeminal nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

CGRP blockers in migraine therapy: where do they act?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

CGRP receptor antagonists: design and screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Safety, tolerability and pharmacokinetics of BIBN 4096 BS, the first selective small molecule calcitonin gene-related peptide receptor antagonist, following single intravenous administration in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

The CGRP-antagonist, BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide8-37 antagonizes capsaicin-induced vasodilation in the skin: evaluation of a human in vivo pharmacodynamic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

BIBN4096BS antagonizes human alpha-calcitonin gene related peptide-induced headache and extracerebral artery dilatation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Randomized, controlled trial of telcagepant for the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

The neuropeptide calcitonin gene-related peptide (CGRP) prevents inflammatory liver injury in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Consensus statement: cardiovascular safety profile of triptans (5-HT agonists) in the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Is there an inherent limit to the efficacy of calcitonin gene-related peptide receptor antagonists in the acute treatment of migraine? A comment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.490829

10.1517/13543784.2010.490829

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20482328