Transient receptor potential vanilloid-1 antagonists: a survey of recent patent literature (Q37768452)

22 August 2017

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title

Transient receptor potential vanilloid-1 antagonists: a survey of recent patent literature (English)

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22 August 2017

Eric A Voight

1

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PubMed ID

20586701

22 August 2017

Michael E Kort

series ordinal

2

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PubMed ID

20586701

22 August 2017

language of work or name

English

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publication date

1 September 2010

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Expert Opinion on Therapeutic Patents

22 August 2017

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22 August 2017

20

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22 August 2017

9

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22 August 2017

1107-1122

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TRP channels: a TR(I)P through a world of multifunctional cation channels

22 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Transient receptor potential ion channels as participants in thermosensation and thermoregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

The capsaicin receptor: a heat-activated ion channel in the pain pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Biochemistry and pharmacology of endovanilloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Capsaicin-induced glutamate release is implicated in nociceptive processing through activation of ionotropic glutamate receptors and group I metabotropic glutamate receptor in primary afferent fibers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Sensitization of primary afferent nociceptors induced by intradermal capsaicin involves the peripheral release of calcitonin gene-related Peptide driven by dorsal root reflexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neu

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

TRPV1 antagonists: the challenges for therapeutic targeting

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Recent progress in the development of selective TRPV1 antagonists for pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

The emerging role of TRPV1 in diabetes and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.497756

10.1517/13543776.2010.497756

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20586701