Biosynthesis of rapamycin and its regulation: past achievements and recent progress (Q37768655)

22 August 2017

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title

Biosynthesis of rapamycin and its regulation: past achievements and recent progress (English)

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22 August 2017

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Sung Ryeol Park

1

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22 August 2017

Young Ji Yoo

series ordinal

2

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22 August 2017

Yeon-Hee Ban

series ordinal

3

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22 August 2017

Yeo Joon Yoon

series ordinal

4

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22 August 2017

language of work or name

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30 June 2010

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The Journal of Antibiotics

22 August 2017

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22 August 2017

63

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22 August 2017

8

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22 August 2017

434-441

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https://scigraph.springernature.com/pub.10.1038/ja.2010.71

22 August 2017

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cites work

Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Rapamycin prevents the onset of insulin-dependent diabetes mellitus (IDDM) in NOD mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Mechanism of action of the immunosuppressant rapamycin

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Pickles, pectin, and penicillin

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Incorporation of acetate, propionate, and methionine into rapamycin by Streptomyces hygroscopicus

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

New rapamycin derivatives by precursor-directed biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Effects of cyclosporin, FK506, and rapamycin on graft-vessel disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Sirolimus: its discovery, biological properties, and mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

mTOR signaling: implications for cancer and anticancer therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Current development of mTOR inhibitors as anticancer agents

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Targeted inhibition of mammalian target of rapamycin for the treatment of advanced renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Genetics of Parkinson disease: paradigm shifts and future prospects.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Dissecting the role of mTOR: lessons from mTOR inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Gramicidin S biosynthesis operon containing the structural genes grsA and grsB has an open reading frame encoding a protein homologous to fatty acid thioesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Initiation of surfactin biosynthesis and the role of the SrfD-thioesterase protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Rapamycin biosynthesis: Elucidation of gene product function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Methionine interference in rapamycin production involves repression of demethylrapamycin methyltransferase and S-adenosylmethionine synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Secondary metabolism in simulated microgravity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Sequence and transcriptional analysis of the Streptomyces glaucescens tcmAR tetracenomycin C resistance and repressor gene loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Accumulation of bldA-specified tRNA is temporally regulated in Streptomyces coelicolor A3(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Genetic improvement of processes yielding microbial products

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Generation of high-yield rapamycin-producing strains through protoplasts-related techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

A high-throughput method for screening of rapamycin-producing strains of Streptomyces hygroscopicus by cultivation in 96-well microtiter plates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Methods for intense aeration, growth, storage, and replication of bacterial strains in microtiter plates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Production of novel rapamycin analogs by precursor-directed biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.71

Novel sulfur-containing rapamycin analogs prepared by precursor-directed biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Biosynthesis of polyketide synthase extender units

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

New antitumor substances of natural origin

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

An unexpected inhibitory effect of rapamycin against germination of spores of Bacillus brevis strain Nagano.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Antifungal activities of rapamycin and its derivatives, prolylrapamycin, 32-desmethylrapamycin, and 32-desmethoxyrapamycin.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Rapamycin inhibits arterial intimal thickening caused by both alloimmune and mechanical injury. Its effect on cellular, growth factor, and cytokine response in injured vessels

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Mammalian target of rapamycin as a therapeutic target in oncology

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus

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https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Effect of nitrogen source on biosynthesis of rapamycin by Streptomyces hygroscopicus

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Growth of Steptomyces hygroscopicus in rotating-wall bioreactor under simulated microgravity inhibits rapamycin production

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Mutagenesis of the rapamycin producer Streptomyces hygroscopicus FC904.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase

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https://api.crossref.org/works/10.1038%2FJA.2010.71

7 January 2021

Identifiers

DOI

10.1038/JA.2010.71

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22 August 2017

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