ABC proteins in antigen translocation and viral inhibition (Q37774234)

23 August 2017

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title

ABC proteins in antigen translocation and viral inhibition (English)

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23 August 2017

2

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23 August 2017

David Parcej

1

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23 August 2017

publication date

1 August 2010

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23 August 2017

published in

Nature Chemical Biology

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23 August 2017

volume

6

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23 August 2017

issue

8

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23 August 2017

page(s)

572-580

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An inward-facing conformation of a putative metal-chelate-type ABC transporter

23 August 2017

cites work

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12 December 2020

Specificity of the proteasome and the TAP transporter

1 reference

12 December 2020

Targeting multidrug resistance in cancer

1 reference

12 December 2020

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

1 reference

12 December 2020

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

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12 December 2020

Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47

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12 December 2020

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

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12 December 2020

Functional dissection of the transmembrane domains of the transporter associated with antigen processing (TAP).

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12 December 2020

ABC transporters: a riddle wrapped in a mystery inside an enigma

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12 December 2020

Tapasin edits peptides on MHC class I molecules by accelerating peptide exchange.

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12 December 2020

A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter.

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12 December 2020

Molecular architecture of the TAP-associated MHC class I peptide-loading complex

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12 December 2020

The active domain of the herpes simplex virus protein ICP47: a potent inhibitor of the transporter associated with antigen processing

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12 December 2020

A sequential model for peptide binding and transport by the transporters associated with antigen processing

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12 December 2020

Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I.

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12 December 2020

A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes

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12 December 2020

Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain

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12 December 2020

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

1 reference

12 December 2020

ABC transporters: physiology, structure and mechanism--an overview

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12 December 2020

The quality control of MHC class I peptide loading

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12 December 2020

Selective loading of high-affinity peptides onto major histocompatibility complex class I molecules by the tapasin-ERp57 heterodimer

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12 December 2020

Insights into MHC Class I Peptide Loading from the Structure of the Tapasin-ERp57 Thiol Oxidoreductase Heterodimer

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12 December 2020

Structure and mechanism of ABC transporters

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12 December 2020

Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing

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12 December 2020

The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex

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12 December 2020

The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation

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12 December 2020

Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation

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12 December 2020

Structure of the viral TAP-inhibitor ICP47 induced by membrane association

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12 December 2020

The ATP switch model for ABC transporters

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12 December 2020

The human cytomegalovirus gene product US6 inhibits ATP binding by TAP

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12 December 2020

Quantification and characterization of P-glycoprotein-substrate interactions

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12 December 2020

Residues in TAP2 peptide transporters controlling substrate specificity

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12 December 2020

Single residue within the antigen translocation complex TAP controls the epitope repertoire by stabilizing a receptive conformation

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12 December 2020

Coping with loss of perfection in the MHC class I peptide repertoire

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12 December 2020

ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

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12 December 2020

Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex.

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12 December 2020

Structure and mechanism of ABC transporter proteins.

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12 December 2020

Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens

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12 December 2020

Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries.

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12 December 2020

A viral inhibitor of peptide transporters for antigen presentation

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12 December 2020

The peptide-binding motif for the human transporter associated with antigen processing

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12 December 2020

Multidrug efflux pumps: drug binding--gates or cavity?

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12 December 2020

Subunit interactions in ABC transporters: towards a functional architecture

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12 December 2020

The redox activity of ERp57 is not essential for its functions in MHC class I peptide loading

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12 December 2020

UCSF Chimera--a visualization system for exploratory research and analysis

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12 December 2020

Proteolysis and class I major histocompatibility complex antigen presentation

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12 December 2020

Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing

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12 December 2020

Substrate specificity of allelic variants of the TAP peptide transporter

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12 December 2020

Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel

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12 December 2020

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP.

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12 December 2020

The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues

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12 December 2020

Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP

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12 December 2020

Interaction of ERp57 and tapasin in the generation of MHC class I-peptide complexes

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12 December 2020

The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation

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12 December 2020

Flexibility in the ABC transporter MsbA: Alternating access with a twist

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12 December 2020

Molecular machinations of the MHC-I peptide loading complex

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12 December 2020

Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition

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12 December 2020

The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter.

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12 December 2020

Herpes simplex virus turns off the TAP to evade host immunity

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12 December 2020

The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p.

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12 December 2020

Membrane topology of the transporter associated with antigen processing (TAP1) within an assembled functional peptide-loading complex

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12 December 2020

A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity

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12 December 2020

Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter

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12 December 2020

Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle

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12 December 2020

Structure of a bacterial multidrug ABC transporter

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12 December 2020

ABC transporters: the power to change

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12 December 2020

How do ABC transporters drive transport?

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12 December 2020

Structure and dynamics of membrane-associated ICP47, a viral inhibitor of the MHC I antigen-processing machinery

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12 December 2020

Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures.

1 reference

12 December 2020

The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation.

1 reference

12 December 2020

Nucleotide interactions with membrane-bound transporter associated with antigen processing proteins

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12 December 2020

ABC Transporters: From Microorganisms to Man

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12 December 2020

A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells

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12 December 2020

Mechanism of substrate sensing and signal transmission within an ABC transporter: use of a Trojan horse strategy

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12 December 2020

The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP

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12 December 2020

Signaling of a varicelloviral factor across the endoplasmic reticulum membrane induces destruction of the peptide-loading complex and immune evasion

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12 December 2020

Functional non-equivalence of ATP-binding cassette signature motifs in the transporter associated with antigen processing (TAP).

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12 December 2020

Requirements for peptide binding to the human transporter associated with antigen processing revealed by peptide scans and complex peptide libraries

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12 December 2020

Structural arrangement of the transmission interface in the antigen ABC transport complex TAP.

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12 December 2020

The nature of the MHC class I peptide loading complex

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12 December 2020

Purification and reconstitution of the antigen transport complex TAP: a prerequisite for determination of peptide stoichiometry and ATP hydrolysis

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12 December 2020

Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling

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12 December 2020

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

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12 December 2020

Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells

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12 December 2020

Molecular mechanism and structural aspects of transporter associated with antigen processing inhibition by the cytomegalovirus protein US6.

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12 December 2020

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

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12 December 2020

The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing

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12 December 2020

Structure of an ABC transporter in complex with its binding protein

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12 December 2020

Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein

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12 December 2020

The Q-loop disengages from the first intracellular loop during the catalytic cycle of the multidrug ABC transporter BmrA.

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12 December 2020

The transporter associated with antigen processing: function and implications in human diseases

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12 December 2020

H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB

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12 December 2020

Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site

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12 December 2020

Regulation of MHC class I assembly and peptide binding

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12 December 2020

Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporter

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12 December 2020

Crystal structure of a catalytic intermediate of the maltose transporter

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.410

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Dimensions Publication ID

23 August 2017

1047982900

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