Chemistry and structure-activity relationship of the styrylquinoline-type HIV integrase inhibitors. (Q37775505)

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Chemistry and structure-activity relationship of the styrylquinoline-type HIV integrase inhibitors (English)

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19 December 2020

2

Didier Desmaële

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23 August 2017

Jean-François Mouscadet

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1

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Didier Desmaële

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2

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language of work or name

English

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publication date

27 April 2010

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issue

5

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3048-3078

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Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

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12 December 2020

Investigations on human immunodeficiency virus type 1 integrase/DNA binding interactions via molecular dynamics and electrostatics calculations.

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12 December 2020

Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture

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12 December 2020

Modeling of the inhibition of retroviral integrases by styrylquinoline derivatives

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12 December 2020

Tautomers of styrylquinoline derivatives containing a methoxy substituent: computation of their population in aqueous solution and their interaction with RSV integrase catalytic core

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12 December 2020

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

1 reference

12 December 2020

Use of patient-derived human immunodeficiency virus type 1 integrases to identify a protein residue that affects target site selection

1 reference

12 December 2020

Styrylquinazoline derivatives as HIV-1 integrase inhibitors

1 reference

12 December 2020

Use of the Kohonen neural network for rapid screening of ex vivo anti-HIV activity of styrylquinolines

1 reference

12 December 2020

Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import

1 reference

12 December 2020

AutoDocking dinucleotides to the HIV-1 integrase core domain: exploring possible binding sites for viral and genomic DNA.

1 reference

12 December 2020

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells

1 reference

12 December 2020

Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America

1 reference

12 December 2020

Synthesis of styrylbenzofuran derivatives as styrylquinoline analogues for HIV-1 integrase inhibitor

1 reference

12 December 2020

Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro

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12 December 2020

Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity

1 reference

12 December 2020

Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents

1 reference

12 December 2020

Exploring binding mode for styrylquinoline HIV-1 integrase inhibitors using comparative molecular field analysis and docking studies

1 reference

12 December 2020

Nuclear import of HIV-1 integrase is inhibited in vitro by styrylquinoline derivatives

1 reference

12 December 2020

Integrase inhibitors to treat HIV/AIDS.

1 reference

12 December 2020

New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity

1 reference

12 December 2020

Retroviral DNA integration--mechanism and consequences

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12 December 2020

Experimental/theoretical electrostatic properties of a styrylquinoline-type HIV-1 integrase inhibitor and its progenitors

1 reference

12 December 2020

A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors

1 reference

12 December 2020

Reversal of Integration and DNA Splicing Mediated by Integrase of Human Immunodeficiency Virus

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12 December 2020

Crystal and electronic structures of magnesium(II), copper(II), and mixed magnesium(II)-copper(II) complexes of the quinoline half of styrylquinoline-type HIV-1 integrase inhibitors.

1 reference

12 December 2020

Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro

1 reference

12 December 2020

Maraviroc, a CCR5 coreceptor antagonist that blocks entry of human immunodeficiency virus type 1.

1 reference

12 December 2020

Treatment of HIV infection with raltegravir

1 reference

12 December 2020

Novel compounds for the treatment of HIV type-1 infection

1 reference

12 December 2020

Emerging role of integrase inhibitors in the management of treatment-experienced patients with HIV infection

1 reference

12 December 2020

Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism

1 reference

12 December 2020

Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo

1 reference

12 December 2020

Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.

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12 December 2020

GSK-1349572, a novel integrase inhibitor for the treatment of HIV infection.

1 reference

12 December 2020

Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking

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12 December 2020

Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells

1 reference

12 December 2020

Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

1 reference

12 December 2020

Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction

1 reference

12 December 2020

10.3390/MOLECULES15053048

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20657464%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20657464%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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