Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials (Q37775799)

23 August 2017

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title

Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials (English)

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23 August 2017

phase III clinical trial

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M A Karsdal

1

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23 August 2017

K Henriksen

2

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23 August 2017

A C Bay-Jensen

3

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23 August 2017

B Molloy

4

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23 August 2017

M Arnold

5

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23 August 2017

M R John

6

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23 August 2017

I Byrjalsen

7

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23 August 2017

M Azria

8

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23 August 2017

B J Riis

9

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23 August 2017

P Qvist

10

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23 August 2017

C Christiansen

11

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23 August 2017

language of work or name

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21 July 2010

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The Journal of Clinical Pharmacology

23 August 2017

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23 August 2017

51

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23 August 2017

4

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23 August 2017

460-471

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https://api.crossref.org/works/10.1177%2F0091270010372625

23 August 2017

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Colonic drug delivery: an updated review

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270010372625

Oral delivery of salmon calcitonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Transmucosal delivery systems for calcitonin: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Bioavailability and biological efficacy of a new oral formulation of salmon calcitonin in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Optimized chemical structure of nanoparticles as carriers for oral delivery of salmon calcitonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

In vivo evaluation of an oral salmon calcitonin-delivery system based on a thiolated chitosan carrier matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Reversible lipidization for the oral delivery of salmon calcitonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Thiomers for oral delivery of hydrophilic macromolecular drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

pH-sensitive microsphere delivery increases oral bioavailability of calcitonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritis

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270010372625

The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model.

21 January 2018

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Approaches to oral drug delivery for challenging molecules

21 January 2018

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Gastroretentive drug delivery systems

21 January 2018

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Oral protein delivery: a patent review of academic and industrial approaches

21 January 2018

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Orally administered glucagon-like peptide-1 affects glucose homeostasis following an oral glucose tolerance test in healthy male subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Pharmacokinetics of modified oral calcitonin product in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Synthesis, characterization and in vivo activity of salmon calcitonin coconjugated with lipid and polyethylene glycol

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Lipeo-sCT: a novel reversible lipidized salmon calcitonin derivative, its biophysical properties and hypocalcemic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Aqueous-soluble, non-reversible lipid conjugate of salmon calcitonin: synthesis, characterization and in vivo activity.

21 January 2018

1 reference

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The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Emerging Trends in Oral Delivery of Peptide and Protein Drugs

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270010372625

A novel per-oral insulin formulation: proof of concept study in non-diabetic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Oral administration of insulin in solid form to nondiabetic and diabetic dogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Nanoparticle strategies for the oral delivery of insulin.

21 January 2018

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Chitosan and its use in design of insulin delivery system

21 January 2018

1 reference

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A novel vitamin B12-nanosphere conjugate carrier system for peroral delivery of insulin.

21 January 2018

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Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development

21 January 2018

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In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist?

21 January 2018

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The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation

21 January 2018

1 reference

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Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI.

21 January 2018

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Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers

21 January 2018

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Oral delivery of insulin with the eligen technology: mechanistic studies

21 January 2018

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Carrier-enhanced human growth hormone absorption across isolated rabbit intestinal tissue.

21 January 2018

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Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Molecular Pharmacology of the Calcitonin Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

A radioimmunoassay for thyrocalcitonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Calcitonin: a drug of the past or for the future? Physiologic inhibition of bone resorption while sustaining osteoclast numbers improves bone quality

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Influence of food intake on the bioavailability and efficacy of oral calcitonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: the effect of water and timing of meal intake on oral delivery of Salmon Calcitonin

21 January 2018

1 reference

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Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteoporosis with oral calcitonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

High-viscosity liquid meal accelerates gastric emptying

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

The effects of oral calcitonin on bone collagen maturation: implications for bone turnover and quality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Application of a new serum assay for type I collagen cross-linked N-telopeptides: assessment of diurnal changes in bone turnover with and without alendronate treatment

21 January 2018

1 reference

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Effect of timing of dosing in relation to food intake on the pharmacokinetics of esomeprazole

21 January 2018

1 reference

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The effect of food on the oral bioavailability and the pharmacodynamic actions of the insulinotropic agent nateglinide in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Marked diurnal variation in urinary excretion of pyridinium cross-links in premenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010372625

Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting

21 January 2018

1 reference

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The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1177/0091270010372625

1 reference

release_jbge2lobhvfb5crwdfu45szcuq

23 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jbge2lobhvfb5crwdfu45szcuq

mapped directly with Wikidata item

24 November 2022

based on heuristic

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