The utility of the minipig as an animal model in regulatory toxicology (Q37777795)

23 August 2017

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title

The utility of the minipig as an animal model in regulatory toxicology (English)

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23 August 2017

Gerd Bode

1

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23 August 2017

Peter Clausing

2

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23 August 2017

Frederic Gervais

3

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23 August 2017

Jeanet Loegsted

4

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23 August 2017

Jörg Luft

5

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23 August 2017

Vicente Nogues

6

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23 August 2017

Jennifer Sims

7

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23 August 2017

Steering Group of the RETHINK Project

8

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23 August 2017

31 May 2010

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Journal of Pharmacological and Toxicological Methods

23 August 2017

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23 August 2017

62

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23 August 2017

3

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23 August 2017

196-220

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Distribution and relative abundance of neurons in the pigeon forebrain containing somatostatin, neuropeptide Y, or both

23 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Xenobiotic metabolism by cultured primary porcine hepatocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Lymphoid tissue structure and lymphocyte trafficking in the pig.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Restricted feeding may induce serous fat atrophy in male Göttingen minipigs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Muscle fiber types: how many and what kind?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The biomarker and endocrine disruptors in mammals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Stimulation of swine growth by porcine growth hormone.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Isolation of porcine expressed sequence tags for the construction of a first genomic transcript map of the skeletal muscle in pig.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

[The Göttinger minipig as a laboratory animal. 4. Communication: respiration parameters (author's transl)]

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Detoxifying activity in pig livers and hepatocytes intended for xenotherapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Prenatal and postnatal growth and development of the central nervous system of the pig

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Comparative aspects of the brain growth spurt

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Cardiotoxicity of vasodilators and positive inotropic/vasodilating drugs in dogs: an overview

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Welfare of the minipig with special reference to use in regulatory toxicology studies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The propionic acids. Gastrointestinal toxicity in various species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Stereotaxic atlas of the pig brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Female mini-pig performance of temporal response differentiation, incremental repeated acquisition, and progressive ratio operant tasks.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The minipig as a platform for new technologies in toxicology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The RETHINK project--minipigs as models for the toxicity testing of new medicines and chemicals: an impact assessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: conclusions and recommendations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Identification of novel foot-and-mouth disease virus specific T-cell epitopes in c/c and d/d haplotype miniature swine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The assessment of skeletal maturation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The minipig model for experimental chondral and osteochondral defect repair in tissue engineering: retrospective analysis of 180 defects.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Measurement of the respiratory volumes of laboratory animals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Patterns of myosin isoforms in mammalian skeletal muscle fibres

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Acetaminophen-induced acute hepatic failure in pigs: controversical results to other animal models.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Differentiating human bone from animal bone: a review of histological methods

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

US FDA "Redbook II" immunotoxicity testing guidelines and research in immunotoxicity evaluations of food chemicals and new food proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Sustained elevation of serum cortisol level causes sensitization of coronary vasoconstricting responses in pigs in vivo: a possible link between stress and coronary vasospasm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Clinical physiology and pathology of the growth plate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Subperiosteal versus epiperiosteal forehead augmentation with hydroxylapatite for aesthetic facial contouring: experimental animal investigation and clinical application

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

In vivo buccal delivery of the peptide drug buserelin with glycodeoxycholate as an absorption enhancer in pigs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

In-vivo buccal delivery of fluorescein isothiocyanate-dextran 4400 with glycodeoxycholate as an absorption enhancer in pigs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Reductions in bone turnover, mineral, and structure associated with mechanical properties of lumbar vertebra and femur in glucocorticoid-treated growing minipigs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

An evaluation of immune competence in different swine breeds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Electrophysiology and pathology evaluation of the Yucatan pig as a non-rodent animal model for regulatory and mechanistic toxicology studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Collagen fibre arrangement in the tibial plateau articular cartilage of man and other mammalian species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

QT PRODACT: usability of miniature pigs in safety pharmacology studies: assessment for drug-induced QT interval prolongation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Regression of diet-induced atherosclerosis in Göttingen miniature swine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Inhalation studies with the Göttingen minipig

7 January 2021

1 reference

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Intranasal midazolam in piglets: pharmacodynamics (0.2 vs 0.4 mg/kg) and pharmacokinetics (0.4 mg/kg) with bioavailability determination.

7 January 2021

1 reference

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Beta-cell function and islet morphology in normal, obese, and obese beta-cell mass-reduced Göttingen minipigs

7 January 2021

1 reference

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Measurements of insulin responses as predictive markers of pancreatic beta-cell mass in normal and beta-cell-reduced lean and obese Göttingen minipigs in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

New insights into muscle fiber types in the pig.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The use of pigs in neuroscience: modeling brain disorders.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Validation of a digital video tracking system for recording pig locomotor behaviour

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Effects of pulmonary embolism on pulmonary vascular impedance in dogs and minipigs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The minipig in dermatotoxicology: methods and challenges.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Xenobiotic-metabolizing enzymes in pig nasal and hepatic tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Validation of the normal, freely moving Göttingen minipig for pharmacological safety testing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Differences among species in compact bone tissue microstructure of mammalian skeleton: use of a discriminant function analysis for species identification

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

MPTP-induced Parkinsonism in minipigs: A behavioral, biochemical, and histological study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Intra-individual comparison of alpha- and beta-TCP ceramics in an animal experiment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Endocrine Physiology of the Puerperal Sow2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Swine as a model of skin inflammation. Phospholipase A2-induced inflammation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Comparative expression of liver cytochrome P450-dependent monooxygenases in the horse and in other agricultural and laboratory species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

A novel spatial Delayed Non-Match to Sample (DNMS) task in the Göttingen minipig

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Comparison of skin transport and metabolism of ethyl nicotinate in various species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Pig hepatocytes as an in vitro model to study the regulation of human CYP3A4: prediction of drug-drug interactions with 17 alpha-ethynylestradiol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Contraceptive steroid toxicology in the Beagle dog and its relevance to human carcinogenicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

CYP2A6: a human coumarin 7-hydroxylase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Skin absorption and human risk assessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The role of vascular endothelial growth factor in glucocorticoid-induced bone loss: evaluation in a minipig model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Evaluation of Göttingen minipig skin for transdermal in vitro permeation studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Drug metabolism in the nasal cavity: relevance to toxicology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Evaluation of animal models for predicting skin penetration in man*1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Review of nonprimate, large animal models for osteoporosis research

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Joint report of the first international comparison test on swine lymphocyte alloantigens (SLA).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The genomic sequence and analysis of the swine major histocompatibility complex

7 January 2021

1 reference

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The pig as a model of developmental immunology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Histochemical properties of fibre types in muscles of wild and domestic pigs and the effect of growth rate on muscle fibre properties

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

T-helper cells from naive to committed.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Myosin isoforms in mammalian skeletal muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Molecular diversity of myofibrillar proteins: gene regulation and functional significance

7 January 2021

1 reference

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Glucocorticosteroid-induced osteoporosis in adult primiparous Göttingen miniature pigs: effects on bone mineral and mineral metabolism

7 January 2021

1 reference

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Excipient effects on gastrointestinal transit and drug absorption in beagle dogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Genetic management of the Göttingen Minipig population

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Human variation in skeletal muscle fiber-type proportion and enzyme activities.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Characterization of the P450 system in Göttingen minipigs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Cytochrome P450 sex differences in minipigs and conventional pigs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Is cytochrome P450 CYP2D activity present in pig liver?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Porcine CYP2A polymorphisms and activity

7 January 2021

1 reference

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Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs

7 January 2021

1 reference

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Cytokine and antibody responses in gnotobiotic pigs after infection with human norovirus genogroup II.4 (HS66 strain)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Clinical review 117: Hormonal determinants and disorders of peak bone mass in children

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model

7 January 2021

1 reference

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Use of the continuous glucose monitoring system in Goettingen Minipigs, with a special focus on the evaluation of insulin-dependent diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

Evaluation of cardiovascular and ECG parameters in the normal, freely moving Göttingen Minipig

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

The minipig in toxicology

7 January 2021

1 reference

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[The Göttinger minipig as an animal model in hip endoprosthesis. Anatomy, anesthesia, operation results]

7 January 2021

1 reference

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Comparative inter-species pharmacokinetics of phenoxyacetic acid herbicides and related organic acids. evidence that the dog is not a relevant species for evaluation of human health risk

7 January 2021

1 reference

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Diurnal variation and age-related changes of bone turnover markers in female Göttingen minipigs

7 January 2021

1 reference

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Standardized data and relationship between bone growth and bone metabolism in female Göttingen minipigs

7 January 2021

1 reference

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Morphologic and immunohistochemical features of experimentally induced allergic contact dermatitis in Göttingen minipigs

7 January 2021

1 reference

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Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products

7 January 2021

1 reference

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Interaction between porcine reproductive-respiratory syndrome virus and bacterial endotoxin in the lungs of pigs: potentiation of cytokine production and respiratory disease

7 January 2021

1 reference

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Proinflammatory cytokines and viral respiratory disease in pigs

7 January 2021

1 reference

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The toxicology profile of the anti-inflammatory drug proquazone in animals

7 January 2021

1 reference

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Immune components in porcine mammary secretions

7 January 2021

1 reference

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Tacrolimus versus cyclosporine induction therapy in pulmonary transplantation in miniature swine

7 January 2021

1 reference

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MR-based statistical atlas of the Göttingen minipig brain.

7 January 2021

1 reference

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Ethical implications of using the minipig in regulatory toxicology studies

7 January 2021

1 reference

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Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved

7 January 2021

1 reference

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A comparative immunohistochemical study of pancreatic islets in laboratory animals (rats, dogs, minipigs, nonhuman primates)

7 January 2021

1 reference

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Effect of fibre content in the diet on the mean retention time in different segments of the digestive tract in growing pigs

7 January 2021

1 reference

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Relationship between myosin heavy chain isoform expression and muscling in several diverse pig breeds.

7 January 2021

1 reference

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Terminology of developmental abnormalities in common laboratory mammals (version 1).

7 January 2021

1 reference

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Effect of surface topology on the osseointegration of implant materials in trabecular bone

7 January 2021

1 reference

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The Göttinger minipig as a laboratory animal. 5. Communication: cardiac output, its regional distribution and organ blood flow (author's transl)

7 January 2021

1 reference

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Transdermal testosterone delivery in castrated Yucatan minipigs: pharmacokinetics and metabolism.

7 January 2021

1 reference

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The porcine Ig delta gene: unique chimeric splicing of the first constant region domain in its heavy chain transcripts.

7 January 2021

1 reference

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Cytochromes P450 and experimental models of drug metabolism.

7 January 2021

1 reference

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Immunocytological study of the chronology of pituitary cytogenesis in the domestic pig (Sus scrofa) with special reference to the functioning of the hypothalamo-pituitary-gonadal axis.

7 January 2021

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.05.009

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.VASCN.2010.05.009

1 reference

23 August 2017

1 reference