The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins (Q37778881)

23 August 2017

2 references

22 October 2022

The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins (English)

1 reference

23 August 2017

Eric J Snijder

2

0 references

author name string

Ying Fang

series ordinal

1

1 reference

23 August 2017

7 August 2010

1 reference

PubMed ID

20696193

23 August 2017

1 December 2010

1 reference

22 October 2022

2 references

23 August 2017

22 October 2022

154

1 reference

23 August 2017

1-2

1 reference

23 August 2017

61-76

1 reference

North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions

23 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Functional properties of the predicted helicase of porcine reproductive and respiratory syndrome virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

De Novo Initiation of RNA Synthesis by the Arterivirus RNA-Dependent RNA Polymerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

In vitro reconstitution of SARS-coronavirus mRNA cap methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Antibody response to porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural proteins and implications for diagnostic detection and differentiation of PRRSV types I and II.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Generation of a candidate live marker vaccine for equine arteritis virus by deletion of the major virus neutralization domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication, but play an important role in modulation of the host immune response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus group

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine reproductive and respiratory syndrome virus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Development of a porcine reproductive and respiratory syndrome virus differentiable (DIVA) strain through deletion of specific immunodominant epitopes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

All subgenomic mRNAs of equine arteritis virus contain a common leader sequence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Vaccine efficacy of porcine reproductive and respiratory syndrome virus chimeras

7 January 2021

1 reference

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Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

A full-length cDNA infectious clone of North American type 1 porcine reproductive and respiratory syndrome virus: expression of green fluorescent protein in the Nsp2 region

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Diversity and evolution of a newly emerged North American Type 1 porcine arterivirus: analysis of isolates collected between 1999 and 2004

7 January 2021

1 reference

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Development of genetic markers in the non-structural protein 2 region of a US type 1 porcine reproductive and respiratory syndrome virus: implications for future recombinant marker vaccine development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Genomic characterization of two Chinese isolates of porcine respiratory and reproductive syndrome virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Complete genomic sequence and phylogenetic analysis of the lactate dehydrogenase-elevating virus (LDV).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Nidovirales: evolving the largest RNA virus genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Complete genome analysis of RFLP 184 isolates of porcine reproductive and respiratory syndrome virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Identification of nonessential regions of the nsp2 replicase protein of porcine reproductive and respiratory syndrome virus strain VR-2332 for replication in cell culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

The porcine reproductive and respiratory syndrome virus nsp2 cysteine protease domain possesses both trans- and cis-cleavage activities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Cross-reactive antibody responses to nsp1 and nsp2 of Porcine reproductive and respiratory syndrome virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

A conventionally attenuated glycoprotein E-negative strain of bovine herpesvirus type 1 is an efficacious and safe vaccine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Expression and stability of foreign tags inserted into nsp2 of porcine reproductive and respiratory syndrome virus (PRRSV).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Insertion and deletion in a non-essential region of the nonstructural protein 2 (nsp2) of porcine reproductive and respiratory syndrome (PRRS) virus: effects on virulence and immunogenicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

A molecular analysis of European porcine reproductive and respiratory syndrome virus isolated in South Korea

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

The nsp1alpha and nsp1 papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Identification of virulence determinants of porcine reproductive and respiratory syndrome virus through construction of chimeric clones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-beta production by interfering with the RIG-I signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Newcastle disease virus (NDV) marker vaccine: an immunodominant epitope on the nucleoprotein gene of NDV can be deleted or replaced by a foreign epitope

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Gradual development of the interferon-γ response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Interferon type I response in porcine reproductive and respiratory syndrome virus-infected MARC-145 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Inactivation of the thymidine kinase gene of a gI deletion mutant of pseudorabies virus generates a safe but still highly immunogenic vaccine strain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus-wide conservation of a replicative endoribonuclease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Arterivirus Nsp1 modulates the accumulation of minus-strand templates to control the relative abundance of viral mRNAs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Epitope mapping porcine reproductive and respiratory syndrome virus by phage display: the nsp2 fragment of the replicase polyprotein contains a cluster of B-cell epitopes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Semen from boars infected with porcine reproductive and respiratory syndrome virus (PRRSV) contains antibodies against structural as well as nonstructural viral proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Sequence requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA synthesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Nidovirus transcription: how to make sense...?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Comparative morphogenesis of three PRRS virus strains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Site-directed mutagenesis of the Nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Formation of the Arterivirus Replication/Transcription Complex: a Key Role for Nonstructural Protein 3 in the Remodeling of Intracellular Membranes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Characterization of emerging European-like porcine reproductive and respiratory syndrome virus isolates in the United States

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

The cap structure of simian hemorrhagic fever virion RNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Antiviral actions of interferons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Coronaviruses use discontinuous extension for synthesis of subgenome-length negative strands

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

7 January 2021

12 December 2020

A contemporary view of coronavirus transcription.

1 reference

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On the size of the active site in proteases. I. Papain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Biochemical characterization of the equine arteritis virus helicase suggests a close functional relationship between arterivirus and coronavirus helicases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

A complex zinc finger controls the enzymatic activities of nidovirus helicases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Determination of the complete nucleotide sequence of a vaccine strain of porcine reproductive and respiratory syndrome virus and identification of the Nsp2 gene with a unique insertion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Proteolytic processing of the replicase ORF1a protein of equine arteritis virus.

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

7 January 2021

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

7 January 2021

The Arterivirus Nsp2 Protease

1 reference

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The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

The molecular biology of arteriviruses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Non-structural proteins 2 and 3 interact to modify host cell membranes during the formation of the arterivirus replication complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Crystal Structure of Porcine Reproductive and Respiratory Syndrome Virus Leader Protease Nsp1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions

7 January 2021

1 reference

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Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark

7 January 2021

1 reference

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Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

A zinc finger-containing papain-like protease couples subgenomic mRNA synthesis to genome translation in a positive-stranded RNA virus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Nuclear localization of non-structural protein 1 and nucleocapsid protein of equine arteritis virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Arterivirus subgenomic mRNA synthesis and virion biogenesis depend on the multifunctional nsp1 autoprotease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

A highly pathogenic porcine reproductive and respiratory syndrome virus generated from an infectious cDNA clone retains the in vivo virulence and transmissibility properties of the parental virus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Proteolytic maturation of replicase polyprotein pp1a by the nsp4 main proteinase is essential for equine arteritis virus replication and includes internal cleavage of nsp7.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Mutagenesis analysis of the nsp4 main proteinase reveals determinants of arterivirus replicase polyprotein autoprocessing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Processing of the equine arteritis virus replicase ORF1b protein: identification of cleavage products containing the putative viral polymerase and helicase domains

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

7 January 2021

12 December 2020

An infectious arterivirus cDNA clone: identification of a replicase point mutation that abolishes discontinuous mRNA transcription

1 reference

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The predicted metal-binding region of the arterivirus helicase protein is involved in subgenomic mRNA synthesis, genome replication, and virion biogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

The in vitro RNA synthesizing activity of the isolated arterivirus replication/transcription complex is dependent on a host factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Arterivirus discontinuous mRNA transcription is guided by base pairing between sense and antisense transcription-regulating sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Characterization of an equine arteritis virus replicase mutant defective in subgenomic mRNA synthesis.

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

7 January 2021

12 December 2020

The use of marker vaccines in eradication of herpesviruses

1 reference

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Development of a genetically marked recombinant rinderpest vaccine expressing green fluorescent protein

7 January 2021

1 reference

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Recombinant rinderpest vaccines expressing membrane-anchored proteins as genetic markers: evidence of exclusion of marker protein from the virus envelope

7 January 2021

1 reference

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Attenuation of porcine reproductive and respiratory syndrome virus strain MN184 using chimeric construction with vaccine sequence

7 January 2021

1 reference

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Classical swine fever virus E(rns) deletion mutants: trans-complementation and potential use as nontransmissible, modified, live-attenuated marker vaccines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Monoclonal antibody and porcine antisera recognized B-cell epitopes of Nsp2 protein of a Chinese strain of porcine reproductive and respiratory syndrome virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Genetic polymorphism of the nsp2 gene in North American type--porcine reproductive and respiratory syndrome virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence.

7 January 2021

1 reference

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Virus-encoded proteinases and proteolytic processing in the Nidovirales.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

7 January 2021

Pathogenic viruses: smart manipulators of the interferon system

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

7 January 2021

Infectious transcripts from cloned genome-length cDNA of porcine reproductive and respiratory syndrome virus.

1 reference

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7 January 2021

Open reading frame 1a-encoded subunits of the arterivirus replicase induce endoplasmic reticulum-derived double-membrane vesicles which carry the viral replication complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2010.07.030

7 January 2021

ORF1a-encoded replicase subunits are involved in the membrane association of the arterivirus replication complex

1 reference

12 December 2020

Nidovirales: a new order comprising Coronaviridae and Arteriviridae

1 reference

12 December 2020

The 5' end of the equine arteritis virus replicase gene encodes a papainlike cysteine protease

1 reference

12 December 2020

Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease.

1 reference

12 December 2020

Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents.

1 reference

12 December 2020

Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily

1 reference

12 December 2020

A sequence pattern common to T cell epitopes

1 reference

12 December 2020

10.1016/J.VIRUSRES.2010.07.030

Identifiers

DOI

1 reference

23 August 2017

0 references

1 reference

PubMed ID

20696193