Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment (Q37779745)

23 August 2017

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title

Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment (English)

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23 August 2017

1

Gianluca Tell

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23 August 2017

Damiano Fantini

2

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23 August 2017

Franco Quadrifoglio

series ordinal

3

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23 August 2017

publication date

13 August 2010

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Cellular and Molecular Life Sciences

23 August 2017

published in

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23 August 2017

volume

67

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23 August 2017

issue

21

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23 August 2017

page(s)

3589-3608

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Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0486-4

Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0486-4

Oxidant-mediated increases in redox factor-1 nuclear protein and activator protein-1 DNA binding in asbestos-treated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0486-4

Thiols in cellular redox signalling and control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0486-4

Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0486-4

21 January 2018

Going APE over ref-1.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0486-4

Mitochondrial localization of APE/Ref-1 in thyroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0486-4

Efficient repair of abasic sites in DNA by mitochondrial enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0486-4

Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0486-4

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

21 January 2018

1 reference

12 December 2020

Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 1 4q11.2 - 12)

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12 December 2020

The base excision repair: mechanisms and its relevance for cancer susceptibility

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12 December 2020

Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.

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12 December 2020

Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

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12 December 2020

Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation

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12 December 2020

The many functions of APE1/Ref-1: not only a DNA repair enzyme

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12 December 2020

XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions

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12 December 2020

Characterization of the DNA-binding properties of the early growth response-1 (Egr-1) transcription factor: evidence for modulation by a redox mechanism

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12 December 2020

Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.

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12 December 2020

Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB

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12 December 2020

Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells

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12 December 2020

Identification of redox/repair protein Ref-1 as a potent activator of p53

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12 December 2020

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites

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12 December 2020

The SET complex acts as a barrier to autointegration of HIV-1

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12 December 2020

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains

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12 December 2020

TSH controls Ref-1 nuclear translocation in thyroid cells

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12 December 2020

Redox effector factor-1 regulates the activity of thyroid transcription factor 1 by controlling the redox state of the N transcriptional activation domain

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12 December 2020

The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

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12 December 2020

Subnuclear organization and trafficking of regulatory proteins: implications for biological control and cancer.

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12 December 2020

Expression of a multifunctional DNA repair enzyme gene, apurinic/apyrimidinic endonuclease (APE; Ref-1) in the suprachiasmatic, supraoptic and paraventricular nuclei

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12 December 2020

DNA repair pathways as targets for cancer therapy

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12 December 2020

Nuclear organization in the 3D space of the nucleus - cause or consequence?

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12 December 2020

Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonuclease

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12 December 2020

A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity

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12 December 2020

Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway

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12 December 2020

SIRT1 deacetylates APE1 and regulates cellular base excision repair

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12 December 2020

The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair

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12 December 2020

Negative regulation of the major human AP-endonuclease, a multifunctional protein

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12 December 2020

A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium

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12 December 2020

Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene

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12 December 2020

Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA

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12 December 2020

Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.

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12 December 2020

Drosophila DNA polymerase zeta interacts with recombination repair protein 1, the Drosophila homologue of human abasic endonuclease 1.

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12 December 2020

Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression

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12 December 2020

XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

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12 December 2020

Granzymes at a glance

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12 December 2020

Radiation-induced cell cycle arrest compromised by p21 deficiency

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12 December 2020

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

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12 December 2020

Redox regulation of DNA repair: implications for human health and cancer therapeutic development

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12 December 2020

The intracellular localization of APE1/Ref-1: more than a passive phenomenon?

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12 December 2020

Increase in Ref-1 mRNA and protein by thyrotropin in rat thyroid FRTL-5 cells

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12 December 2020

Purification and characterization of a Mg2+-dependent endonuclease (AN34) from etoposide-treated human leukemia HL-60 cells undergoing apoptosis

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12 December 2020

Downregulation of APE1/Ref-1 is involved in the senescence of mesenchymal stem cells.

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12 December 2020

Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion

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12 December 2020

Cellular antioxidant effects of atorvastatin in vitro and in vivo

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12 December 2020

APE1/Ref-1 regulates PTEN expression mediated by Egr-1

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12 December 2020

Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

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12 December 2020

Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity

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12 December 2020

Redox-dependent transcriptional regulation

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12 December 2020

Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.

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12 December 2020

Evidence that the bifunctional redox factor / AP endonuclease Ref-1 is an anti-apoptotic protein associated with differentiation in the developing retina

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12 December 2020

Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase

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12 December 2020

DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

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12 December 2020

Probing conformational changes in Ape1 during the progression of base excision repair

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12 December 2020

Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1.

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12 December 2020

NOPdb: Nucleolar Proteome Database

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12 December 2020

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death

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12 December 2020

Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis

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12 December 2020

Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: a basis for its role in human disease

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12 December 2020

Loss of redox factor 1 decreases NF-kappaB activity and increases susceptibility of endothelial cells to apoptosis

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12 December 2020

Current molecular models for NADPH oxidase regulation by Rac GTPase

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12 December 2020

Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme

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12 December 2020

Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression

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12 December 2020

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

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12 December 2020

Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter

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12 December 2020

Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation.

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12 December 2020

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).

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12 December 2020

Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310

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12 December 2020

Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision

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12 December 2020

A role of cyclin G in the process of apoptosis

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12 December 2020

Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice

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12 December 2020

Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis

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12 December 2020

Structural characterization of the 5' regions of the human phenylalanine hydroxylase gene

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12 December 2020

Analysis of repair of abasic sites in early onset breast cancer patients

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12 December 2020

The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium

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12 December 2020

Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.

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12 December 2020

Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium

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12 December 2020

Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells

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12 December 2020

Nucleolar proteome dynamics

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12 December 2020

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.

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12 December 2020

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

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12 December 2020

Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1

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12 December 2020

A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells.

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12 December 2020

Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.

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12 December 2020

Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair

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12 December 2020

Ref-1 controls pax-8 DNA-binding activity

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12 December 2020

Rac1 disrupts p67phox/p40phox binding: a novel role for Rac in NADPH oxidase activation

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12 December 2020

Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair

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12 December 2020

Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding

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12 December 2020

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

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12 December 2020

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme

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12 December 2020

APE/Ref-1 and the mammalian response to genotoxic stress

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12 December 2020

Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism

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12 December 2020

Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.

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12 December 2020

Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1

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12 December 2020

Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop

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12 December 2020

Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?

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12 December 2020

Characterization of the promoter region of the human apurinic endonuclease gene (APE).

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12 December 2020

NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases

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12 December 2020

Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization

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12 December 2020

Regulation of blood calcium in humans

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12 December 2020

High-performance affinity beads for identifying drug receptors

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12 December 2020

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

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12 December 2020

Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins

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12 December 2020

Two essential but distinct functions of the mammalian abasic endonuclease

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12 December 2020

Key role of a downstream specificity protein 1 site in cell cycle-regulated transcription of the AP endonuclease gene APE1/APEX in NIH3T3 cells

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12 December 2020

Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo.

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12 December 2020

Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA

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12 December 2020

Endothelin-1 induces NAD(P)H oxidase in human endothelial cells

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12 December 2020

Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA.

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12 December 2020

Hypocalcemia increases and hypercalcemia decreases the steady-state level of parathyroid hormone messenger RNA in the rat.

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12 December 2020

An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels

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12 December 2020

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity

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12 December 2020

Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage

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12 December 2020

Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors

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12 December 2020

Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12

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12 December 2020

The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress

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12 December 2020

Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway

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12 December 2020

Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activity

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12 December 2020

Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain

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12 December 2020

Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein.

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12 December 2020

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death

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12 December 2020

Properties of a superoxide anion-generating microsomal NADH oxidoreductase, a potential pulmonary artery PO2 sensor.

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12 December 2020

Important role for Rac1 in regulating reactive oxygen species generation and pulmonary arterial smooth muscle cell growth

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12 December 2020

Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1

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12 December 2020

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

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12 December 2020

10.1007/S00018-010-0486-4

Identifiers

DOI

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23 August 2017

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