Are synucleinopathies prion-like disorders? (Q37789524)

23 August 2017

title

Are synucleinopathies prion-like disorders? (English)

1 reference

23 August 2017

0 references

1 reference

5

Patrik Brundin

1 reference

23 August 2017

Elodie Angot

1

1 reference

23 August 2017

Jennifer A Steiner

series ordinal

2

1 reference

23 August 2017

Christian Hansen

series ordinal

3

1 reference

23 August 2017

Jia-Yi Li

series ordinal

4

1 reference

23 August 2017

publication date

16 September 2010

1 reference

23 August 2017

1 reference

23 August 2017

volume

9

1 reference

23 August 2017

issue

11

1 reference

23 August 2017

page(s)

1128-1138

1 reference

Alpha-synuclein misfolding and neurodegenerative diseases

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Beyond the prion principle

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The transcellular spread of cytosolic amyloids, prions, and prionoids

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Prion-like mechanisms in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Is Parkinson's disease a prion disorder?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Prion-like transmission of protein aggregates in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The propagation of prion-like protein inclusions in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Novel proteinaceous infectious particles cause scrapie

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Shattuck lecture--neurodegenerative diseases and prions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Characteristics of established and proposed sporadic Creutzfeldt-Jakob disease variants

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

1 reference

7 January 2021

Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Context dependent neuroprotective properties of prion protein (PrP).

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

No propagation of prions in mice devoid of PrP.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

PrP-deficient mice are resistant to scrapie

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

NMR structure of the mouse prion protein domain PrP(121-231)

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Natural and synthetic prion structure from X-ray fiber diffraction

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The physical basis of how prion conformations determine strain phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The octarepeat region of the prion protein is conformationally altered in PrP(Sc)

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Low entropic barrier to the hydrophobic collapse of the prion protein: effects of intermediate states and conformational flexibility.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Design and construction of diverse mammalian prion strains

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Cells release prions in association with exosomes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Prions hijack tunnelling nanotubes for intercellular spread

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Packaging of prions into exosomes is associated with a novel pathway of PrP processing.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Exosomes--vesicular carriers for intercellular communication

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Exosomes: a bubble ride for prions?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Membrane nanotubes: dynamic long-distance connections between animal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Prions and their lethal journey to the brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The pathogenesis and biochemistry of amyloidosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Propagation of tau misfolding from the outside to the inside of a cell.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Transmission and spreading of tauopathy in transgenic mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The progression of pathology in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Lewy-body formation is an aggresome-related process: a hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages).

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Staging of brain pathology related to sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Stages in the development of Parkinson's disease-related pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Multiple system atrophy: an update.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Identification of two distinct synucleins from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Parkinson's disease: a dual-hit hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Parkinson's disease: the dual hit theory revisited

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Preliminary diagnosis of Parkinson's disease by olfactory bulb pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

alpha-Synucleinopathy in the human olfactory system in Parkinson's disease: involvement of calcium-binding protein- and substance P-positive cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Early Parkinson's disease and non-motor issues

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Non-motor symptoms in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Progression of Parkinson's disease in the clinical phase: potential markers

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Neural transplantation for the treatment of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Dopaminergic transplantation for Parkinson's disease: current status and future prospects

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Transplanted dopaminergic neurons develop PD pathologic changes: a second case report

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Lewy body pathology in fetal grafts

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Research in motion: the enigma of Parkinson's disease pathology spread

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Professional exposure to pesticides and Parkinson disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Parkinson's disease and pesticides: a toxicological perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

A highly reproducible rotenone model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Molecular mechanisms of alpha-synuclein neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Formation and development of Lewy pathology: a critical update

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Striatal neuroinflammation promotes Parkinsonism in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Exosomes are released by cultured cortical neurones.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

A new hypothesis of pathogenesis based on the divorce between mitochondria and their host cells: possible relevance for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

The scientific and clinical basis for the treatment of Parkinson disease (2009).

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

A double-blind, delayed-start trial of rasagiline in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

Biological fluid biomarkers in neurodegenerative parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970213-1

7 January 2021

10.1016/S1474-4422(10)70213-1

Identifiers

DOI

1 reference

23 August 2017

1 reference