Gfi1 and Gfi1b: key regulators of hematopoiesis (Q37791430)

23 August 2017

Gfi1 and Gfi1b: key regulators of hematopoiesis (English)

1 reference

23 August 2017

0 references

L T van der Meer

1

1 reference

PubMed ID

20861919

23 August 2017

J H Jansen

series ordinal

2

1 reference

PubMed ID

20861919

23 August 2017

B A van der Reijden

series ordinal

3

1 reference

23 August 2017

23 September 2010

1 reference

23 August 2017

1 reference

23 August 2017

24

1 reference

23 August 2017

11

1 reference

23 August 2017

1834-1843

1 reference

https://scigraph.springernature.com/pub.10.1038/leu.2010.195

23 August 2017

0 references

cites work

The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Solution structure of Gfi-1 zinc domain bound to consensus DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi-1B promoter remains associated with active chromatin marks throughout erythroid differentiation of human primary progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

GFI1B controls its own expression binding to multiple sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Loss of MicroRNA targets in the 3' untranslated region as a mechanism of retroviral insertional activation of growth factor independence 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

GATA-1 forms distinct activating and repressive complexes in erythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Characterization of megakaryocyte GATA1-interacting proteins: the corepressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Sumoylation of CoREST modulates its function as a transcriptional repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

p53 regulates hematopoietic stem cell quiescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Multilineage transcriptional priming and determination of alternate hematopoietic cell fates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1 regulates miR-21 and miR-196b to control myelopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1 integrates progenitor versus granulocytic transcriptional programming

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The growth factor independence-1 (Gfi1) is overexpressed in chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Prognostically useful gene-expression profiles in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The growth factor independence-1 transcription factor: new functions and new insights.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Retracted: Transcriptional Repressor Gfi1 Integrates Cytokine-Receptor Signals Controlling B-Cell Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Transcription factor Gfi1 restricts B cell-mediated autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Transcription factors in myeloid development: balancing differentiation with transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

PLZF is a regulator of homeostatic and cytokine-induced myeloid development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

Regulation of pulmonary Pseudomonas aeruginosa infection by the transcriptional repressor Gfi1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

7 January 2021

The zinc finger protein Gfi1 acts upstream of TNF to attenuate endotoxin-mediated inflammatory responses in the lung

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

7 January 2021

Regulation of transcription factor activity by SUMO modification

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

7 January 2021

Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

7 January 2021

CD34, RAB20, PU.1 and GFI1 mRNA expression in myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

7 January 2021

Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

7 January 2021

New genes involved in cancer identified by retroviral tagging

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

7 January 2021

The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Igamma2b germline transcripts

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.195

7 January 2021

Identifiers

DOI

10.1038/LEU.2010.195

1 reference

23 August 2017

1 reference

PubMed ID

20861919