Alternatives to calcineurin inhibition in renal transplantation: belatacept, the first co-stimulation blocker. (Q37793216)

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14 February 2020

title

Alternatives to calcineurin inhibition in renal transplantation: belatacept, the first co-stimulation blocker (English)

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3

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author name string

Nicolas Poirier

series ordinal

1

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Gilles Blancho

series ordinal

2

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publication date

1 September 2010

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14 February 2020

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14 February 2020

volume

2

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issue

5

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page(s)

625-636

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Drug insight: maintenance immunosuppression in kidney transplant recipients

14 February 2020

cites work

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The natural history of chronic allograft nephropathy

21 January 2018

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Diabetes mellitus after kidney transplantation in the United States

21 January 2018

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A randomized, multicenter study of steroid avoidance, early steroid withdrawal or standard steroid therapy in kidney transplant recipients

21 January 2018

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Reduced exposure to calcineurin inhibitors in renal transplantation

21 January 2018

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Chronic allograft dysfunction: can we use mammalian target of rapamycin inhibitors to replace calcineurin inhibitors to preserve graft function?

21 January 2018

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Compared with cyclosporine, ISATX247 significantly prolongs renal-allograft survival in a nonhuman primate model

21 January 2018

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Sotrastaurin, a novel small molecule inhibiting protein kinase C: first clinical results in renal-transplant recipients.

21 January 2018

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Monitoring of the immunomodulatory effect of CP-690,550 by analysis of the JAK/STAT pathway in kidney transplant patients

21 January 2018

1 reference

Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates

21 January 2018

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What's next in the pipeline

21 January 2018

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Tolerance and chimerism after renal and hematopoietic-cell transplantation

21 January 2018

1 reference

HLA-mismatched renal transplantation without maintenance immunosuppression

21 January 2018

1 reference

CTLA-4 is a second receptor for the B cell activation antigen B7

21 January 2018

1 reference

Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.

21 January 2018

1 reference

CD28-mediated co-stimulation: a quantitative support for TCR signalling

21 January 2018

1 reference

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

21 January 2018

1 reference

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

21 January 2018

1 reference

Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation.

21 January 2018

1 reference

The interaction properties of costimulatory molecules revisited.

21 January 2018

1 reference

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

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Molecular basis of T cell inactivation by CTLA-4

21 January 2018

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Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function

21 January 2018

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CTLA-4: new insights into its biological function and use in tumor immunotherapy

21 January 2018

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CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

21 January 2018

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Fas-independent death of activated CD4(+) T lymphocytes induced by CTLA-4 crosslinking

21 January 2018

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Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells

21 January 2018

1 reference

Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.

21 January 2018

1 reference

What's the difference between CD80 and CD86?

21 January 2018

1 reference

CTLA-4 control over Foxp3+ regulatory T cell function

21 January 2018

1 reference

Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation

21 January 2018

1 reference

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

21 January 2018

1 reference

The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation

21 January 2018

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Reversal of the TCR stop signal by CTLA-4

21 January 2018

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CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization

21 January 2018

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Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses

21 January 2018

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Interaction of human PD-L1 and B7-1.

21 January 2018

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CTLA-4-Ig regulates tryptophan catabolism in vivo.

21 January 2018

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Modulation of tryptophan catabolism by regulatory T cells.

21 January 2018

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IDO expression by dendritic cells: tolerance and tryptophan catabolism

21 January 2018

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Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells.

21 January 2018

1 reference

Nitric oxide and indoleamine 2,3-dioxygenase mediate CTLA4Ig-induced survival in heart allografts in rats.

21 January 2018

1 reference

CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenase

21 January 2018

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Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction

21 January 2018

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Abatacept does not induce direct gene expression changes in antigen-presenting cells

21 January 2018

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Dendritic cells secrete the immunosuppressive HLA-G molecule upon CTLA4-Ig treatment: implication in human renal transplant acceptance.

21 January 2018

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Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates

21 January 2018

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CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

21 January 2018

1 reference

Strategies for tolerance induction to composite tissue allografts

21 January 2018

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Secretion of CTLA4Ig by an SV40 T antigen-transformed islet cell line inhibits graft rejection against the neoantigen

21 January 2018

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Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA4Ig expression.

21 January 2018

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Memory T-cell-specific therapeutics in organ transplantation

21 January 2018

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Heterologous immunity: an overlooked barrier to tolerance

21 January 2018

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Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.

21 January 2018

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Treatment of murine lupus with CTLA4Ig

21 January 2018

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CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

21 January 2018

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Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules

21 January 2018

1 reference

Costimulation blockade with belatacept in renal transplantation

21 January 2018

1 reference

A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study).

21 January 2018

1 reference

CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris

21 January 2018

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Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.

21 January 2018

1 reference

Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis

21 January 2018

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Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection

21 January 2018

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Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection

21 January 2018

1 reference

CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis

21 January 2018

1 reference

Absence of CD4CD25 regulatory T cell expansion in renal transplanted patients treated in vivo with Belatacept mediated CD28-CD80/86 blockade

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/IMT.10.57

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14 February 2020

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