Ikaros in immune receptor signaling, lymphocyte differentiation, and function. (Q37796303)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20888815%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Ikaros in immune receptor signaling, lymphocyte differentiation, and function (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20888815%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

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Matthias Merkenschlager

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20888815%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

author name string

Matthias Merkenschlager

series ordinal

1

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23 August 2017

language of work or name

English

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publication date

2 October 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20888815%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

number of pages

5

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based on heuristic

inferred from page(s)

published in

FEBS Letters

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20888815%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

volume

584

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20888815%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

issue

24

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20888815%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

page(s)

4910-4914

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20888815%20AND%20SRC:MED&resulttype=core&format=json

Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment

14 February 2020

cites work

1 reference

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Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system

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Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities

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Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression

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Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

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Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

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Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression

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Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division

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Ikaros has a crucial role in regulation of B cell receptor signaling.

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B cell signaling and tumorigenesis

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Defects in hemopoietic stem cell activity in Ikaros mutant mice

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Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells

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Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function

21 January 2018

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Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development

21 January 2018

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Ikaros controls isotype selection during immunoglobulin class switch recombination

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Ikaros is a regulator of Il10 expression in CD4+ T cells

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Proteins of the Ikaros family control dendritic cell maturation required to induce optimal Th1 T cell differentiation

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

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Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE

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Ikaros is required for plasmacytoid dendritic cell differentiation

21 January 2018

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Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization

21 January 2018

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Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels

21 January 2018

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Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

21 January 2018

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21 January 2018

It's T-ALL about Notch

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Ikaros represses the transcriptional response to Notch signaling in T-cell development

21 January 2018

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Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation

21 January 2018

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Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice

21 January 2018

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Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing

21 January 2018

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BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

21 January 2018

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