Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes (Q37803277)

23 August 2017

title

Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes (English)

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23 August 2017

Ann-Kristin Mossberg

1

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23 August 2017

Kenneth Hun Mok

series ordinal

2

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23 August 2017

Ludmilla A Morozova-Roche

series ordinal

3

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23 August 2017

Catharina Svanborg

series ordinal

4

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23 August 2017

language of work or name

English

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publication date

1 November 2010

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23 August 2017

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23 August 2017

volume

277

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23 August 2017

issue

22

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23 August 2017

page(s)

4614-4625

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Principles that govern the folding of protein chains

23 August 2017

cites work

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Can misfolded proteins be beneficial? The HAMLET case

21 January 2018

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HAMLET treatment delays bladder cancer development

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Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells

21 January 2018

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Creation and phenotypic analysis of alpha-lactalbumin-deficient mice

21 January 2018

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Milk protein gene expression in the rat mammary gland.

21 January 2018

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The evolution of lysozyme and alpha-lactalbumin

21 January 2018

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Molecular divergence of lysozymes and alpha-lactalbumin

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Structural characterisation and comparison of the native and A-states of equine lysozyme.

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Amyloid protofilaments from the calcium-binding protein equine lysozyme: formation of ring and linear structures depends on pH and metal ion concentration

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Heat-treatment method for producing fatty acid-bound alpha-lactalbumin that induces tumor cell death

21 January 2018

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Effect of denaturation of alpha-lactalbumin on the formation of BAMLET (bovine alpha-lactalbumin made lethal to tumor cells).

21 January 2018

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Who is Mr. HAMLET? Interaction of human alpha-lactalbumin with monomeric oleic acid

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Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells.

21 January 2018

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Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei

21 January 2018

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alpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding

21 January 2018

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Alpha-lactalbumin forms a compact molten globule in the absence of disulfide bonds.

21 January 2018

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Conformational analysis of HAMLET, the folding variant of human alpha-lactalbumin associated with apoptosis

21 January 2018

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Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells)

21 January 2018

1 reference

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Lipids as cofactors in protein folding: stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).

21 January 2018

1 reference

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Structural changes of alpha-lactalbumin induced by low pH and oleic acid.

21 January 2018

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HAMLET interacts with lipid membranes and perturbs their structure and integrity

21 January 2018

1 reference

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The interaction of equine lysozyme:oleic acid complexes with lipid membranes suggests a cargo off-loading mechanism

21 January 2018

1 reference

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HAMLET interacts with histones and chromatin in tumor cell nuclei

21 January 2018

1 reference

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Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival

21 January 2018

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HAMLET, protein folding, and tumor cell death

21 January 2018

1 reference

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Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells).

21 January 2018

1 reference

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Changes in proteasome structure and function caused by HAMLET in tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07890.X

Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.

21 January 2018

1 reference

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No need to be HAMLET or BAMLET to interact with histones: binding of monomeric alpha-lactalbumin to histones and basic poly-amino acids

21 January 2018

1 reference

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A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria

21 January 2018

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Protease activation in apoptosis induced by MAL

21 January 2018

1 reference

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HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.

21 January 2018

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Autophagy: molecular machinery for self-eating

21 January 2018

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Autophagy: dual roles in life and death?

21 January 2018

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Autophagy and cell death.

21 January 2018

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Apoptosis: identification of dying cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07890.X

Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07890.X

Protein misfolding, functional amyloid, and human disease

21 January 2018

1 reference

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Functional amyloid formation within mammalian tissue

21 January 2018

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Prions as adaptive conduits of memory and inheritance

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07890.X

Independent Nucleation and Heterogeneous Assembly of Structure During Folding of Equine Lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07890.X

Compact oleic acid in HAMLET

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07890.X

The oleic acid complexes of proteolytic fragments of α-lactalbumin display apoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07890.X

10.1111/J.1742-4658.2010.07890.X

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference