Gap junctions or hemichannel-dependent and independent roles of connexins in cataractogenesis and lens development. (Q37811014)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21091421%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Gap junctions or hemichannel-dependent and independent roles of connexins in cataractogenesis and lens development (English)

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16 January 2020

author name string

J X Jiang

series ordinal

1

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16 January 2020

publication date

1 December 2010

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Current Molecular Medicine

16 January 2020

published in

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16 January 2020

volume

10

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16 January 2020

issue

9

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16 January 2020

page(s)

851-863

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Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells

16 January 2020

cites work

1 reference

12 December 2020

Connexin 50 mutation in a family with congenital "zonular nuclear" pulverulent cataract of Pakistani origin

1 reference

12 December 2020

Heteromeric connexons formed by the lens connexins, connexin43 and connexin56.

1 reference

12 December 2020

Connexin43: a protein from rat heart homologous to a gap junction protein from liver

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12 December 2020

Dominant cataracts result from incongruous mixing of wild-type lens connexins

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12 December 2020

Structural and functional diversity of connexin genes in the mouse and human genome

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12 December 2020

Gap junctional hemichannels in the heart

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12 December 2020

A novel connexin46 (GJA3) mutation in autosomal dominant congenital nuclear pulverulent cataract

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12 December 2020

Hemichannel and junctional properties of connexin 50.

1 reference

12 December 2020

Electrical properties of gap junction hemichannels identified in transfected HeLa cells

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12 December 2020

Localization of steady currents in the lens

1 reference

12 December 2020

A Gja8 (Cx50) point mutation causes an alteration of alpha 3 connexin (Cx46) in semi-dominant cataracts of Lop10 mice

1 reference

12 December 2020

Intercellular communication between epithelial and fiber cells of the eye lens

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12 December 2020

A novel mutation in GJA8 associated with autosomal dominant congenital cataract in a family of Indian origin.

1 reference

12 December 2020

Gap junctional coupling in lenses lacking alpha3 connexin

1 reference

12 December 2020

1 reference

12 December 2020

A novel mutation in GJA8 associated with jellyfish-like cataract in a family of Indian origin

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12 December 2020

A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts.

1 reference

12 December 2020

Cellular and molecular features of lens differentiation: a review of recent advances

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12 December 2020

Physiological properties of the normal lens

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12 December 2020

A novel "pearl box" cataract associated with a mutation in the connexin 46 (GJA3) gene

1 reference

12 December 2020

Cardiac malformation in neonatal mice lacking connexin43.

1 reference

12 December 2020

Distribution of connexin50 channels and hemichannels in lens fibers: a structural approach

1 reference

12 December 2020

Intercellular Calcium Signaling Occurs between Human Osteoblasts and Osteoclasts and Requires Activation of Osteoclast P2X7 Receptors

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12 December 2020

Properties of a nonjunctional current expressed from a rat connexin46 cDNA in Xenopus oocytes

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12 December 2020

Attempts to define functional domains of gap junction proteins with synthetic peptides

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12 December 2020

Changes in connexin expression and distribution during chick lens development.

1 reference

12 December 2020

Microphthalmia and cataract in rats with a novel point mutation in connexin 50 - L7Q.

1 reference

12 December 2020

Visualization and functional blocking of gap junction hemichannels (connexons) with antibodies against external loop domains in astrocytes

1 reference

12 December 2020

Hemichannel-mediated inhibition in the outer retina

1 reference

12 December 2020

Evidence for two physiologically distinct gap junctions expressed by the chick lens epithelial cell

1 reference

12 December 2020

A mutation in the connexin 50 (Cx50) gene is a candidate for the No2 mouse cataract

1 reference

12 December 2020

Hemichannels formed by connexin 43 play an important role in the release of prostaglandin E(2) by osteocytes in response to mechanical strain

1 reference

12 December 2020

Microarray analysis of fiber cell maturation in the lens

1 reference

12 December 2020

Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells

1 reference

12 December 2020

Molecular basis of calcium regulation in connexin-32 hemichannels

1 reference

12 December 2020

Stimulation of Lens Cell Differentiation by Gap Junction Protein Connexin 45.6

1 reference

12 December 2020

Loss of function and impaired degradation of a cataract-associated mutant connexin50.

1 reference

12 December 2020

Transgenic overexpression of connexin50 induces cataracts

1 reference

12 December 2020

A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant "zonular pulverulent" cataract, on chromosome 1q

1 reference

12 December 2020

The congenital "ant-egg" cataract phenotype is caused by a missense mutation in connexin46.

1 reference

12 December 2020

Defining a link between gap junction communication, proteolysis, and cataract formation

1 reference

12 December 2020

Mapping of A gene responsible for cataract formation and its modifier in the UPL rat.

1 reference

12 December 2020

Lens structure in MIP-deficient mice

1 reference

12 December 2020

Molecular mechanism underlying a Cx50-linked congenital cataract.

1 reference

12 December 2020

Membrane alterations during cataract development in the Nakano mouse lens

1 reference

12 December 2020

Identification of a 70,000-D protein in lens membrane junctional domains

1 reference

12 December 2020

An aberrant sequence in a connexin46 mutant underlies congenital cataracts.

1 reference

12 December 2020

Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts.

1 reference

12 December 2020

Connexins in lens development and cataractogenesis

1 reference

12 December 2020

Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes

1 reference

12 December 2020

Two novel mutations of connexin genes in Chinese families with autosomal dominant congenital nuclear cataract

1 reference

12 December 2020

Interaction of major intrinsic protein (aquaporin-0) with fiber connexins in lens development

1 reference

12 December 2020

Lens fiber connexin turnover and caspase-3-mediated cleavage are regulated alternately by phosphorylation

1 reference

12 December 2020

Promotion of lens epithelial-fiber differentiation by the C-terminus of connexin 45.6 a role independent of gap junction communication

1 reference

12 December 2020

The gap junction communication channel

1 reference

12 December 2020

Connexin50 is essential for normal postnatal lens cell proliferation

1 reference

12 December 2020

Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation

1 reference

12 December 2020

Gating and regulation of connexin 43 (Cx43) hemichannels

1 reference

12 December 2020

Molecular cloning of ovine connexin44 and temporal expression of gap junction proteins in a lens cell culture.

1 reference

12 December 2020

Structural changes in lenses of mice lacking the gap junction protein connexin43

1 reference

12 December 2020

Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation

1 reference

12 December 2020

Lens differentiation and crystallin regulation: a chick model

1 reference

12 December 2020

Cell-to-cell fusion of lens fiber cells in situ: correlative light, scanning electron microscopic, and freeze-fracture studies

1 reference

12 December 2020

Connexin46 mutations in autosomal dominant congenital cataract

1 reference

12 December 2020

Functional and morphological correlates of connexin50 expressed in Xenopus laevis oocytes

1 reference

12 December 2020

Connexins are mechanosensitive.

1 reference

12 December 2020

Connexin 46 and connexin 50 in selenite cataract

1 reference

12 December 2020

Connexin channel permeability to cytoplasmic molecules

1 reference

12 December 2020

Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice

1 reference

12 December 2020

Crystallins and hereditary cataracts: molecular mechanisms and potential for therapy

1 reference

12 December 2020

Modulation of junctional communication by phosphorylation: protein phosphatases, the missing link in the chain

1 reference

12 December 2020

Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation

1 reference

12 December 2020

Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70

1 reference

12 December 2020

Heteromeric connexons in lens gap junction channels

1 reference

12 December 2020

Normal differentiation of cultured lens cells after inhibition of gap junction-mediated intercellular communication

1 reference

12 December 2020

Novel mutations in GJA3 associated with autosomal dominant congenital cataract in the Indian population

1 reference

12 December 2020

Identification of global gene expression differences between human lens epithelial and cortical fiber cells reveals specific genes and their associated pathways important for specialized lens cell functions

1 reference

12 December 2020

Regulation of lens rCx46-formed hemichannels by activation of protein kinase C, external Ca(2+) and protons.

1 reference

12 December 2020

Lens gap junctional coupling is modulated by connexin identity and the locus of gene expression

1 reference

12 December 2020

Beyond the gap: functions of unpaired connexon channels

1 reference

12 December 2020

Genetic background influences cataractogenesis, but not lens growth deficiency, in Cx50-knockout mice

1 reference

12 December 2020

Transduction of cell survival signals by connexin-43 hemichannels

1 reference

12 December 2020

ATP release from human airway epithelial cells studied using a capillary cell culture system

1 reference

12 December 2020

Casein kinase II phosphorylates lens connexin 45.6 and is involved in its degradation

1 reference

12 December 2020

Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis

1 reference

12 December 2020

Connections between connexins, calcium, and cataracts in the lens.

1 reference

12 December 2020

Optimal lens epithelial cell proliferation is dependent on the connexin isoform providing gap junctional coupling

1 reference

12 December 2020

Gap junctional coupling in lenses from alpha(8) connexin knockout mice

1 reference

12 December 2020

The distribution of the fiber cell intrinsic membrane proteins MP20 and connexin46 in the bovine lens

1 reference

12 December 2020

Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels

1 reference

12 December 2020

Gap junction- and hemichannel-independent actions of connexins

1 reference

12 December 2020

A novel mutation in the connexin 46 (GJA3) gene associated with autosomal dominant congenital cataract in an Indian family.

1 reference

12 December 2020

Mutation of the gap junction protein alpha 8 (GJA8) gene causes autosomal recessive cataract

1 reference

12 December 2020

Regulation of connexin hemichannels by monovalent cations

1 reference

12 December 2020

Genetic heterogeneity in microcornea-cataract: five novel mutations in CRYAA, CRYGD, and GJA8.

1 reference

12 December 2020

Differential connexin expression, gap junction intercellular coupling, and hemichannel formation in NT2/D1 human neural progenitors and terminally differentiated hNT neurons

1 reference

12 December 2020

Dual mechanism of intercellular communication in HOBIT osteoblastic cells: a role for gap-junctional hemichannels

1 reference

12 December 2020

Genetic diseases of junctions.

1 reference

12 December 2020

The crystalline lens. A system networked by gap junctional intercellular communication

1 reference

12 December 2020

pH gating of lens fibre connexins

1 reference

12 December 2020

Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin

1 reference

12 December 2020

Mutation in the connexin 50 gene (GJA8) in a Russian family with zonular pulverulent cataract

1 reference

12 December 2020

Gap junction hemichannels in astrocytes of the CNS.

1 reference

12 December 2020

A novel mutation in the connexin 46 gene (GJA3) causes autosomal dominant zonular pulverulent cataract in a Hispanic family

1 reference

12 December 2020

Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)

1 reference

12 December 2020

Growth factor regulation of lens development

1 reference

12 December 2020

A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract

1 reference

12 December 2020

Characterization of a mouse Cx50 mutation associated with the No2 mouse cataract.

1 reference

12 December 2020

Gap junction channel structure in the early 21st century: facts and fantasies

1 reference

12 December 2020

Assembly of connexins and MP26 in lens fiber plasma membranes studied by SDS-fracture immunolabeling

1 reference

12 December 2020

Gap junction communication influences intercellular protein distribution in the lens

1 reference

12 December 2020

Properties of gap junction channels formed by Cx46 alone and in combination with Cx50.

1 reference

12 December 2020

Novel mutations in GJA8 associated with autosomal dominant congenital cataract and microcornea.

1 reference

12 December 2020

A non-connexon protein (MIP) is involved in eye lens gap-junction formation

1 reference

12 December 2020

The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins.

1 reference

12 December 2020

Interaction of connexins with protein partners in the control of channel turnover and gating.

1 reference

12 December 2020

Prenatal lens development in connexin43 and connexin50 double knockout mice

1 reference

12 December 2020

Further evidence of autosomal dominant congenital zonular pulverulent cataracts linked to 13q11 (CZP3) and a novel mutation in connexin 46 (GJA3)

1 reference

12 December 2020

Molecular solutions to mammalian lens transparency.

1 reference

12 December 2020

Connexins, connexons, and intercellular communication

1 reference

12 December 2020

Molecular cloning and functional characterization of chick lens fiber connexin 45.6.

1 reference

12 December 2020

Role of C-terminal domain and transmembrane helices 5 and 6 in function and quaternary structure of major intrinsic proteins: analysis of aquaporin/glycerol facilitator chimeric proteins

1 reference

12 December 2020

An ultrastructural analysis of the epithelial-fiber interface (EFI) in primate lenses

1 reference

12 December 2020

Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins

1 reference

12 December 2020

Gating of cx46 gap junction hemichannels by calcium and voltage

1 reference

12 December 2020

A novel connexin 50 (GJA8) mutation in a Chinese family with a dominant congenital pulverulent nuclear cataract.

1 reference

12 December 2020

New genetic model rat for congenital cataracts due to a connexin 46 (Gja3 ) mutation

1 reference

12 December 2020

A novel mutation in the Connexin 46 gene causes autosomal dominant congenital cataract with incomplete penetrance

1 reference

12 December 2020

Translational regulation of delta-crystallin synthesis during lens development in the chicken embryo

1 reference

12 December 2020

Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels

1 reference

12 December 2020

Connexins, gap junctional intercellular communication and kinases

1 reference

12 December 2020

Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype

1 reference

12 December 2020

Open pore block of connexin26 and connexin32 hemichannels by neutral, acidic and basic glycoconjugates

1 reference

12 December 2020

A novel mutation in GJA3 (connexin46) for autosomal dominant congenital nuclear pulverulent cataract

1 reference

12 December 2020

Structural and immunocytochemical alterations in eye lens fiber cells from Cx46 and Cx50 knockout mice

1 reference

12 December 2020

A novel GJA8 mutation in an Iranian family with progressive autosomal dominant congenital nuclear cataract.

1 reference

12 December 2020

1 reference

12 December 2020

A novel GJA8 mutation causing a recessive triangular cataract.

1 reference

12 December 2020

The gating effect of calmodulin and calcium on the connexin50 hemichannel

1 reference

12 December 2020

Developmental regulation of the direct interaction between the intracellular loop of connexin 45.6 and the C terminus of major intrinsic protein (aquaporin-0).

1 reference

12 December 2020

Opening hemichannels in nonjunctional membrane stimulates gap junction formation

1 reference

12 December 2020

Gating of retinal horizontal cell hemi gap junction channels by voltage, Ca2+, and retinoic acid

1 reference

12 December 2020

A novel missense mutation in the gene for gap-junction protein alpha3 (GJA3) associated with autosomal dominant "nuclear punctate" cataracts linked to chromosome 13q

1 reference

12 December 2020

Chick connexin-56, a novel lens gap junction protein. Molecular cloning and functional expression

1 reference

12 December 2020

Life cycle of connexins in health and disease

1 reference

12 December 2020

Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract

1 reference

12 December 2020

Co-expression of lens fiber connexins modifies hemi-gap-junctional channel behavior

1 reference

12 December 2020

Effect of external magnesium and calcium on human connexin46 hemichannels

1 reference

12 December 2020

Micro-domains of AQP0 in lens equatorial fibers

1 reference

12 December 2020

Unique and redundant connexin contributions to lens development

1 reference

12 December 2020

Connexin46 mutations linked to congenital cataract show loss of gap junction channel function.

1 reference

12 December 2020

10.2174/156652410793937750

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21091421%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21091421%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

21091421

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