Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications (Q37821136)

23 August 2017

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title

Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications (English)

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23 August 2017

1

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author name string

Ursula Ravens

series ordinal

1

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23 August 2017

Erich Wettwer

series ordinal

2

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23 August 2017

publication date

15 December 2010

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23 August 2017

published in

Cardiovascular Research

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23 August 2017

volume

89

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23 August 2017

issue

4

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23 August 2017

page(s)

776-785

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Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium

23 August 2017

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21 January 2018

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Modeling the binding modes of Kv1.5 potassium channel and blockers

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21 January 2018

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Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit

21 January 2018

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Modulation of Kv channel alpha/beta subunit interactions

21 January 2018

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A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing

21 January 2018

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Comparison of binding and block produced by alternatively spliced Kvbeta1 subunits

21 January 2018

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Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits

21 January 2018

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Rab-GTPase-dependent endocytic recycling of Kv1.5 in atrial myocytes

21 January 2018

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Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain

21 January 2018

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Protein kinase A phosphorylation alters Kvbeta1.3 subunit-mediated inactivation of the Kv1.5 potassium channel

21 January 2018

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Phosphorylation is required for alteration of kv1.5 K(+) channel function by the Kvbeta1.3 subunit

21 January 2018

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Endocytosis as a mechanism for tyrosine kinase-dependent suppression of a voltage-gated potassium channel.

21 January 2018

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SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5.

21 January 2018

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Cysteine oxidation and rundown of large-conductance Ca2+-dependent K+ channels

21 January 2018

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Modulation of Kv1.5 currents by protein kinase A, tyrosine kinase, and protein tyrosine phosphatase requires an intact cytoskeleton

21 January 2018

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Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit

21 January 2018

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Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5.

21 January 2018

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SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism

21 January 2018

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The anchoring protein SAP97 retains Kv1.5 channels in the plasma membrane of cardiac myocytes

21 January 2018

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Four and a half LIM protein 1: a partner for KCNA5 in human atrium

21 January 2018

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Involvement of lipid rafts and caveolae in cardiac ion channel function.

21 January 2018

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Caveolae: from cell biology to animal physiology

21 January 2018

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Isoform-specific localization of voltage-gated K+ channels to distinct lipid raft populations. Targeting of Kv1.5 to caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Rapid and slow components of delayed rectifier current in human atrial myocytes.

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression

21 January 2018

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Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

21 January 2018

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The ultrarapid and the transient outward K(+) current in human atrial fibrillation. Their possible role in postoperative atrial fibrillation

21 January 2018

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Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation

21 January 2018

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Potassium leak channels and the KCNK family of two-P-domain subunits

21 January 2018

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Functional characterization of a Ca(2+)-activated non-selective cation channel in human atrial cardiomyocytes

21 January 2018

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Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts

21 January 2018

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Antiarrhythmic therapy in atrial fibrillation

21 January 2018

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Common variants in KCNN3 are associated with lone atrial fibrillation

21 January 2018

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Variants conferring risk of atrial fibrillation on chromosome 4q25.

21 January 2018

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Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation

21 January 2018

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Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation

21 January 2018

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Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation

21 January 2018

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The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation

21 January 2018

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Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation.

21 January 2018

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Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Role of potassium currents in cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Cellular mechanisms of depressed atrial contractility in patients with chronic atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Molecular basis for a high-potency open-channel block of Kv1.5 channel by the endocannabinoid anandamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Immobilisation of gating charge by a substance that simulates inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

New drugs targeting the cardiac ultra-rapid delayed-rectifier current (I Kur): rationale, pharmacology and evidence for potential therapeutic value

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Structural basis for competition between drug binding and Kvbeta 1.3 accessory subunit-induced N-type inactivation of Kv1.5 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Kvbeta1.3 reduces the degree of stereoselective bupivacaine block of Kv1.5 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

The molecular basis of high-affinity binding of the antiarrhythmic compound vernakalant (RSD1235) to Kv1.5 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Polymorphism screening in the cardiac K+ channel gene KCNA5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Human cardiac potassium channel DNA polymorphism modulates access to drug-binding site and causes drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

"Early" class III drugs for the treatment of atrial fibrillation: efficacy and atrial selectivity of AVE0118 in remodeled atria of the goat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Atrial effects of the novel K(+)-channel-blocker AVE0118 in anesthetized pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Effect of atrial electrical remodeling on the efficacy of antiarrhythmic drugs: comparison of amiodarone with I(Kr)- and I(to)/IKur-blockade in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Characterization of a novel Kv1.5 channel blocker in Xenopus oocytes, CHO cells, human and rat cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Vernakalant hydrochloride for rapid conversion of atrial fibrillation: a phase 3, randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Vernakalant hydrochloride for the rapid conversion of atrial fibrillation after cardiac surgery: a randomized, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

The mechanism of atrial antiarrhythmic action of RSD1235.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Vernakalant (RSD1235): a novel, atrial-selective antifibrillatory agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Atrial-selective pharmacological therapy for atrial fibrillation: hype or hope?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Novel anti-arrhythmic drugs for atrial fibrillation management.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Atrial-selective sodium channel block for the treatment of atrial fibrillation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ398

21 January 2018

Identifiers

DOI

10.1093/CVR/CVQ398

1 reference

23 August 2017

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