Gain and loss of T cell subsets in old age--age-related reshaping of the T cell repertoire (Q37829691)

24 August 2017

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title

Gain and loss of T cell subsets in old age--age-related reshaping of the T cell repertoire (English)

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Beatrix Grubeck-Loebenstein

24 August 2017

author

5

object named as

Beatrix Grubeck-Loebenstein

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Dietmar Herndler-Brandstetter

24 August 2017

4

object named as

Dietmar Herndler-Brandstetter

1 reference

24 August 2017

Christoph R Arnold

1

1 reference

24 August 2017

Juliane Wolf

2

1 reference

24 August 2017

Stefan Brunner

3

1 reference

24 August 2017

publication date

18 January 2011

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Journal of Clinical Immunology

24 August 2017

published in

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24 August 2017

volume

31

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24 August 2017

issue

2

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24 August 2017

page(s)

137-146

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Biology of immune responses to vaccines in elderly persons

24 August 2017

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IL-7 is critical for homeostatic proliferation and survival of naive T cells

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Can the immune system still be efficient in the elderly? An immunological and immunoendocrine therapeutic perspective

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Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice

21 January 2018

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The effect of age on the cognate function of CD4+ T cells

21 January 2018

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Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice

21 January 2018

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Antigen-independent changes in naive CD4 T cells with aging

21 January 2018

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Age-dependent defects in TCR-triggered cytoskeletal rearrangement in CD4+ T cells

21 January 2018

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Effects of aging on T cell function

21 January 2018

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Importance of culturing primary lymphocytes at physiological oxygen levels

21 January 2018

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Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation.

21 January 2018

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21 January 2018

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Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

21 January 2018

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Regulation of naïve and memory T-cell homeostasis

21 January 2018

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Naïve to memory T-cell differentiation during homeostasis-driven proliferation

21 January 2018

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The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells

21 January 2018

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21 January 2018

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21 January 2018

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IL-4-producing CD8+ T cells with a CD62L++(bright) phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age.

21 January 2018

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CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load

21 January 2018

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Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons

21 January 2018

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High antigen levels are the cause of T cell exhaustion during chronic viral infection

21 January 2018

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Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion.

21 January 2018

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Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects

21 January 2018

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Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly

21 January 2018

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Novel mechanism of signaling by CD28.

21 January 2018

1 reference

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The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation.

21 January 2018

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Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians.

21 January 2018

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CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity

21 January 2018

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Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects.

21 January 2018

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Susceptibility of naïve and subsets of memory T cells to apoptosis via multiple signaling pathways

21 January 2018

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21 January 2018

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Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging.

21 January 2018

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microRNAs and the immune response

21 January 2018

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Microarray analysis reveals similarity between CD8+CD28- T cells from young and elderly persons, but not of CD8+CD28+ T cells.

21 January 2018

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CD28(-) T cells: their role in the age-associated decline of immune function

21 January 2018

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miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging

21 January 2018

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21 January 2018

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21 January 2018

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Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines

21 January 2018

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Inflamm-aging. An evolutionary perspective on immunosenescence

21 January 2018

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21 January 2018

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21 January 2018

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Human cytomegalovirus seropositivity is associated with impaired vascular function

21 January 2018

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Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity.

21 January 2018

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Human CMV infection of endothelial cells induces an angiogenic response through viral binding to EGF receptor and beta1 and beta3 integrins

21 January 2018

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Cytomegalovirus infection causes an increase of arterial blood pressure

21 January 2018

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21 January 2018

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Rejuvenation of the aging T cell compartment

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Strong dietary restrictions protect Drosophila against anoxia/reoxygenation injuries

21 January 2018

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mTOR regulates memory CD8 T-cell differentiation

21 January 2018

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Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

21 January 2018

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Healthy Aging and Latent Infection with CMV Lead to Distinct Changes in CD8+ and CD4+ T-Cell Subsets in the Elderly

21 January 2018

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Changes in thymic function with age and during the treatment of HIV infection

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Exclusive increase of CX3CR1+CD28-CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes

21 January 2018

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12 December 2020

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No immunity for the elderly

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Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T-cells in old age

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Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts

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Human cytomegalovirus persistently infects aortic endothelial cells

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10.1007/S10875-010-9499-X

Identifiers

DOI

1 reference

24 August 2017

1 reference