Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease (Q37832642)

24 August 2017

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title

Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease (English)

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24 August 2017

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Adriana S Dusso

1

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PubMed ID

21270766

24 August 2017

Masanori Tokumoto

series ordinal

2

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PubMed ID

21270766

24 August 2017

language of work or name

English

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publication date

26 January 2011

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24 August 2017

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24 August 2017

79

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24 August 2017

715-729

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24 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/ki.2010.543

24 August 2017

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1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III)

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

https://api.crossref.org/works/10.1038%2FKI.2010.543

1 reference

7 January 2021

Role of phosphorus in the pathogenesis of secondary hyperparathyroidism

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Activated injectable vitamin D and hemodialysis survival: a historical cohort study

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Oral active vitamin D is associated with improved survival in hemodialysis patients

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Vitamin D in chronic kidney disease: a systemic role for selective vitamin D receptor activation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Vitamin D and kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

25-hydroxyvitamin D levels and the risk of mortality in the general population

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

25-hydroxyvitamin D levels, race, and the progression of kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Vitamin D levels and early mortality among incident hemodialysis patients

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signaling

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

The phosphatonin pathway: new insights in phosphate homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Suppression of aging in mice by the hormone Klotho

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Synthesis and metabolic clearance of 1,25-dihydroxyvitamin D as determinants of serum concentrations: a comparison of two methods

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https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus.

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https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

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https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Vitamin D: Metabolism and Biological Actions

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Parathyroid hormone fragments inhibit active hormone and hypocalcemia-induced 1,25(OH)2D synthesis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Altered divalent ion metabolism in early renal failure: role of 1,25(OH)2D

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

ADAM17 upregulation in human renal disease: a role in modulating TGF-alpha availability?

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Plasma Vitamin D Metabolite Concentrations in Chronic Renal Failure: Effect of Oral Administration of 25-Hydroxyvitamin D3*

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Metabolic clearance rate and production rate of calcitriol in uremia

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Radioligand receptor assay for 25-hydroxyvitamin D2/D3 and 1 alpha, 25-dihydroxyvitamin D2/D3

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Gene expression of vitamin D hydroxylase and megalin in the remnant kidney of nephrectomized rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Regulation of gp330/megalin expression by vitamins A and D

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Changes in Serum 25-Hydroxyvitamin D and Plasma Intact PTH Levels Following Treatment With Ergocalciferol in Patients With CKD

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Pharmacokinetics of a single, large dose of cholecalciferol

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Effects of vitamin D supplementation on the calcium-phosphate balance in renal transplant patients

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Antiproteinuric effect of oral paricalcitol in chronic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Paricalcitol reduces albuminuria and inflammation in chronic kidney disease: a randomized double-blind pilot trial

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Calcitriol metabolism in patients with chronic renal failure

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol: conversion impaired by systemic metabolic acidosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

The effect of 22-oxacalcitriol on serum calcitriol

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

A new analog of 1,25-(OH)2D3, 19-NOR-1,25-(OH)2D2, suppresses serum PTH and parathyroid gland growth in uremic rats without elevation of intestinal vitamin D receptor content

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Extra-renal production of calcitriol in chronic renal failure

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Extrarenal production of calcitriol in normal and uremic humans

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

1alpha-Hydroxylase transactivation by gamma-interferon in murine macrophages requires enhanced C/EBPbeta expression and activation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Vitamin D: criteria for safety and efficacy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Paricalcitol aggravates perivascular fibrosis in rats with renal insufficiency and low calcitriol

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

1,25-Dihydroxyvitamin D3-induced HL-60 macrophages: regulation of cholesterol and LDL metabolism

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

1 alpha,25-dihydroxyvitamin D3 induces very low density lipoprotein receptor mRNA expression in HL-60 cells in association with monocytic differentiation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

25-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Characterization of the human Megalin/LRP-2 promoter in vitro and in primary parathyroid cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Impact of ergocalciferol treatment of vitamin D deficiency on serum parathyroid hormone concentrations in chronic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Cholecalciferol (vitamin D3) therapy and vitamin D insufficiency in patients with chronic kidney disease: a randomized controlled pilot study

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Vitamin D2 is much less effective than vitamin D3 in humans

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Low-dose calcitriol prevents the rise in 1,84-iPTH without affecting serum calcium and phosphate in patients with moderate renal failure (prospective placebo-controlled multicentre trial)

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Doxercalciferol safely suppresses PTH levels in patients with secondary hyperparathyroidism associated with chronic kidney disease stages 3 and 4.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Effect of 18 months of treatment with alfacalcidol on bone in patients with mild to moderate chronic renal failure

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Fibroblast growth factor 23: the making of a hormone.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa).

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Renoprotective effects of vitamin D analogs

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Potential effects of 1,25-dihydroxyvitamin D3 in renal transplant recipients

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Renal tubule albumin transport

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Mechanisms of disease: what can mouse models tell us about the molecular processes underlying Dent disease?

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Proteasomal processing of albumin by renal dendritic cells generates antigenic peptides

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Direct transcriptional regulation of RelB by 1alpha,25-dihydroxyvitamin D3 and its analogs: physiologic and therapeutic implications for dendritic cell function.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Post-transcriptional up-regulation of ADAM17 upon epidermal growth factor receptor activation and in breast tumors.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

EGFR activation increases parathyroid hyperplasia and calcitriol resistance in kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

p21WAF1 and TGF-alpha mediate parathyroid growth arrest by vitamin D and high calcium

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Improvement of renal hemodynamics during hypertension-induced chronic renal disease: role of EGF receptor antagonism.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1).

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17).

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Renoprotective effect of rosiglitazone through the suppression of renal intercellular adhesion molecule-1 expression in streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Increased plasma and endothelial cell expression of chemokines and adhesion molecules in chronic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Circulating markers of endothelial dysfunction interact with proteinuria in predicting mortality in renal transplant recipients.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Arterial calcification: a tumor necrosis factor-alpha mediated vascular Wnt-opathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

1,25-Dihydroxyvitamin D down-regulates cell membrane growth- and nuclear growth-promoting signals by the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.543

7 January 2021

Identifiers

DOI

10.1038/KI.2010.543

1 reference

24 August 2017

1 reference

PubMed ID

21270766