The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease (Q37840099)

24 August 2017

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title

The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease (English)

1 reference

24 August 2017

Pamela J Hornby

1

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PubMed ID

21314232

24 August 2017

Beverley A Moore

series ordinal

2

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PubMed ID

21314232

24 August 2017

language of work or name

English

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publication date

11 February 2011

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Expert Opinion on Therapeutic Targets

24 August 2017

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24 August 2017

15

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24 August 2017

5

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24 August 2017

637-646

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The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent protein kinase-independent pathway

24 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-like peptide 2 function in domestic animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Frontiers in glucagon-like peptide-2: multiple actions, multiple mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Review article: glucagon-like peptide 2--current applications and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Enteroendocrine localization of GLP-2 receptor expression in humans and rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Modulation of specific intestinal epithelial progenitors by enteric neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Role of cholinergic neurons in the motor effects of glucagon-like peptide-2 in mouse colon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-like peptide (GLP)-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon like peptide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

21 January 2018

Glucagon-like Peptide-2.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-like peptide-2 acutely increases proximal small intestinal blood flow in TPN-fed neonatal piglets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-like peptide-2 inhibits antral emptying in man, but is not as potent as glucagon-like peptide-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Biological actions and therapeutic potential of the glucagon-like peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-like peptide-2: update of the recent clinical trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Intestinal adaptation: structure, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Growth factors: possible roles for clinical management of the short bowel syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Fgf9 signaling regulates small intestinal elongation and mesenchymal development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Short bowel syndrome: the role of GLP-2 on improving outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

The assessment, and glucagon-like peptide-2 modulation, of intestinal absorption and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-like peptide-2 increases mesenteric blood flow in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Population pharmacokinetics of teduglutide following repeated subcutaneous administrations in healthy participants and in patients with short bowel syndrome and Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

GLP-2 levels in infants with intestinal dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Diet- and Colonization-Dependent Intestinal Dysfunction Predisposes to Necrotizing Enterocolitis in Preterm Pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

The influence of nutrients, biliary-pancreatic secretions, and systemic trophic hormones on intestinal adaptation in a Roux-en-Y bypass model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Temporal changes in the intestinal growth promoting effects of glucagon-like peptide 2 following intestinal resection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Persistent alterations to enteric neural signaling in the guinea pig colon following the resolution of colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagonlike peptide-2 analogue: a possible new approach in the management of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Growth factor based therapies and intestinal disease: is glucagon-like peptide-2 the new way forward?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Metabolic effects of the incretin mimetic exenatide in the treatment of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Stress impairs murine intestinal barrier function: improvement by glucagon-like peptide-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

GLP-2 receptor agonism ameliorates inflammation and gastrointestinal stasis in murine postoperative ileus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

The effect of glucagon-like peptide 2 on intestinal permeability and bacterial translocation in acute necrotizing pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Postoperative ileus: a preventable event

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Neostigmine resolves critical illness-related colonic ileus in intensive care patients with multiple organ failure--a prospective, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Ileus in critical illness: mechanisms and management

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Effect of glucagon, glicentin, glucagon-like peptide-1 and -2 on interdigestive gastroduodenal motility in dogs with a vagally denervated gastric pouch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Clinical significance of weight loss in cancer patients: rationale for the use of anabolic agents in the treatment of cancer-related cachexia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Up-regulation of early growth response gene 1 (EGR-1) via ERK1/2 signals attenuates sulindac sulfide-mediated cytotoxicity in the human intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Cost of chemotherapy-induced thrombocytopenia among patients with lymphoma or solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Clinical review: Healing in gastrointestinal anastomoses, part II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

The effect of growth hormone on the bursting strength of ileal anastomotic segments in radiation-injured rat bowel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Contribution of insulin-like growth factor I to the healing of colonic anastomoses in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Localization and Activation of Glucagon-Like Peptide-2 Receptors on Vagal Afferents in the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

Glucagon-Like Peptide-2 Inhibits Centrally Induced Antral Motility in Pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.556620

10.1517/14728222.2011.556620

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21314232