Statins are logical candidates for overcoming limitations of targeting therapies on malignancy: their potential application to gastrointestinal cancers (Q37843836)

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scientific article published on 17 February 2011

Language	Label	Description	Also known as
English	Statins are logical candidates for overcoming limitations of targeting therapies on malignancy: their potential application to gastrointestinal cancers	scientific article published on 17 February 2011

Statements

scholarly article

1 reference

Europe PubMed Central

24 August 2017

1 reference

Europe PubMed Central

Statins are logical candidates for overcoming limitations of targeting therapies on malignancy: their potential application to gastrointestinal cancers (English)

1 reference

Europe PubMed Central

24 August 2017

author name string

Shouji Shimoyama

1

1 reference

Europe PubMed Central

24 August 2017

publication date

17 February 2011

1 reference

Europe PubMed Central

24 August 2017

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

24 August 2017

67

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Europe PubMed Central

24 August 2017

4

1 reference

Europe PubMed Central

24 August 2017

729-739

1 reference

Europe PubMed Central

24 August 2017

https://scigraph.springernature.com/pub.10.1007/s00280-011-1583-2

0 references

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1 reference

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A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.

1 reference

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21 January 2018

Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study

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21 January 2018

Phase II study of a combination of S-1 and paclitaxel in patients with unresectable or metastatic gastric cancer

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21 January 2018

Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer

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EGFR antagonists in cancer treatment

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Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer

1 reference

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21 January 2018

Rho family proteins: coordinating cell responses

1 reference

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Ras and Rho regulation of the cell cycle and oncogenesis

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What tangled webs they weave: Rho-GTPase control of angiogenesis.

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Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro

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Vascular endothelial growth factor in colorectal cancer

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Anti-angiogenic therapy against gastrointestinal tract cancers

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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

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EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer

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Cetuximab for the treatment of colorectal cancer.

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Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

1 reference

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21 January 2018

Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer

1 reference

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21 January 2018

Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer

1 reference

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21 January 2018

Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor.

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21 January 2018

Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.

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Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer

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American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy

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Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer

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Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

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Statins-mediated inhibition of rho GTPases as a potential tool in anti-tumor therapy

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Activation of Raf as a result of recruitment to the plasma membrane

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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Protein lipidation in cell signaling

1 reference

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A geranylgeranyltransferase for rhoA p21 distinct from the farnesyltransferase for ras p21S.

1 reference

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Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

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Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect

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Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study.

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Rho GTPases are over-expressed in human tumors.

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RhoC is essential for the metastasis of gastric cancer

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Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity

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Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer

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The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

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Regulation of the mevalonate pathway

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Potential Anticancer Effects of Statins: Fact or Fiction?

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Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation

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Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells

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3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.

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Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins

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Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells.

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (pravastatin) inhibits endothelial cell proliferation dependent on G1 cell cycle arrest

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Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells.

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Lovastatin inhibits the stimulation of mitogen-activated protein kinase by insulin in HIRcB fibroblasts

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Lovastatin is a potent inhibitor of meningioma cell proliferation: evidence for inhibition of a mitogen associated protein kinase

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Pravastatin suppresses the interleukin-8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinase

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Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs

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Inhibition of proliferation and signalling mechanisms in human lymphocytes by fluvastatin

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Mevastatin induces apoptosis in HL60 cells dependently on decrease in phosphorylated ERK.

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Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor

1 reference

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Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth

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Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.

1 reference

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Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide

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Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice

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Prevention of 1,2-dimethylhydrazine-induced colon tumorigenesis by HMG-CoA reductase inhibitors, pravastatin and simvastatin, in ICR mice.

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Phase II study of high-dose lovastatin in patients with advanced gastric adenocarcinoma

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A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix

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Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial

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Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines

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Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro

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Lovastatin enhances gefitinib activity in glioblastoma cells irrespective of EGFRvIII and PTEN status

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Mutations of the BRAF gene in human cancer

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https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE00766

Identifiers

10.1007/S00280-011-1583-2

1 reference

Europe PubMed Central

24 August 2017

1 reference

Europe PubMed Central

24 August 2017

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