RNA helicases p68 and p72: multifunctional proteins with important implications for cancer development (Q37846229)

24 August 2017

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title

RNA helicases p68 and p72: multifunctional proteins with important implications for cancer development (English)

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24 August 2017

Frances V Fuller-Pace

series ordinal

1

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PubMed ID

21345143

24 August 2017

Hayley C Moore

series ordinal

2

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PubMed ID

21345143

24 August 2017

language of work or name

English

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publication date

1 February 2011

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24 August 2017

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24 August 2017

7

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24 August 2017

2

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24 August 2017

239-251

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Dead-box proteins: a family affair--active and passive players in RNP-remodeling

24 August 2017

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Role of DEAD box 1 in retinoblastoma and neuroblastoma

21 January 2018

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Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation

21 January 2018

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p72: a human nuclear DEAD box protein highly related to p68

21 January 2018

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DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation

21 January 2018

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The mRNA of DEAD box protein p72 is alternatively translated into an 82-kDa RNA helicase

21 January 2018

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Expression of the 'dead box' RNA helicase p68 is developmentally and growth regulated and correlates with organ differentiation/maturation in the fetus.

21 January 2018

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A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA

21 January 2018

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p68, a DEAD-box RNA helicase, is expressed in chordate embryo neural and mesodermal tissues.

21 January 2018

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Developmental and tissue-specific expression of DEAD box protein p72

21 January 2018

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p68 DEAD box RNA helicase expression in keratinocytes. Regulation, nucleolar localization, and functional connection to proliferation and vascular endothelial growth factor gene expression

21 January 2018

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Expression of p68 RNA helicase is closely related to the early stage of adipocyte differentiation of mouse 3T3-L1 cells

21 January 2018

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Redundant role of DEAD box proteins p68 (Ddx5) and p72/p82 (Ddx17) in ribosome biogenesis and cell proliferation

21 January 2018

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DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs

21 January 2018

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Overexpression and poly-ubiquitylation of the DEAD-box RNA helicase p68 in colorectal tumours.

21 January 2018

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The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer

21 January 2018

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The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer

21 January 2018

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Signaling to the DEAD box--regulation of DEAD-box p68 RNA helicase by protein phosphorylations

21 January 2018

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P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin

21 January 2018

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Phosphorylation of p68 RNA helicase plays a role in platelet-derived growth factor-induced cell proliferation by up-regulating cyclin D1 and c-Myc expression.

21 January 2018

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A double tyrosine phosphorylation of P68 RNA helicase confers resistance to TRAIL-induced apoptosis

21 January 2018

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The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor

21 January 2018

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Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha

21 January 2018

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Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

21 January 2018

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Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300

21 January 2018

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Functional interaction between Smad, CREB binding protein, and p68 RNA helicase

21 January 2018

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Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA

21 January 2018

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Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen

21 January 2018

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The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner

21 January 2018

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A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells

21 January 2018

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Estrogen regulation and physiopathologic significance of alternative promoters in breast cancer.

21 January 2018

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Tumor suppressive functions of p53

21 January 2018

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The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer

21 January 2018

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Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF

21 January 2018

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Androgen receptor coregulators and their involvement in the development and progression of prostate cancer.

21 January 2018

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The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation

21 January 2018

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p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation

21 January 2018

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The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription

21 January 2018

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Regulation of bone development and extracellular matrix protein genes by RUNX2.

21 January 2018

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Gene expression signatures and biomarkers of noninvasive and invasive breast cancer cells: comprehensive profiles by representational difference analysis, microarrays and proteomics

21 January 2018

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The connection between splicing and cancer.

21 January 2018

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Unbalanced alternative splicing and its significance in cancer

21 January 2018

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Detection of a novel ATP-dependent cross-linked protein at the 5' splice site-U1 small nuclear RNA duplex by methylene blue-mediated photo-cross-linking

21 January 2018

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p68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplex

21 January 2018

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RH70, a bidirectional RNA helicase, co-purifies with U1snRNP

21 January 2018

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RAS in cellular transformation and senescence

21 January 2018

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Expression of the H-ras proto-oncogene is controlled by alternative splicing

21 January 2018

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Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation

21 January 2018

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P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras

21 January 2018

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Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72.

21 January 2018

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Coordinate regulation of transcription and splicing by steroid receptor coregulators

21 January 2018

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A subset of nuclear receptor coregulators act as coupling proteins during synthesis and maturation of RNA transcripts

21 January 2018

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The Drosophila P68 RNA helicase regulates transcriptional deactivation by promoting RNA release from chromatin

21 January 2018

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Many roads to maturity: microRNA biogenesis pathways and their regulation

21 January 2018

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Causes and consequences of microRNA dysregulation in cancer

21 January 2018

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MicroRNA function in cancer: oncogene or a tumor suppressor?

21 January 2018

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MicroRNAs, macrocontrol: regulation of miRNA processing

21 January 2018

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MicroRNAs in cancer: small molecules with a huge impact

21 January 2018

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A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

21 January 2018

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P68 RNA helicase is a nucleocytoplasmic shuttling protein

21 January 2018

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P68 RNA helicase unwinds the human let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene expression

21 January 2018

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The Microprocessor complex mediates the genesis of microRNAs

21 January 2018

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SMAD proteins control DROSHA-mediated microRNA maturation

21 January 2018

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Modulation of microRNA processing by p53

21 January 2018

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Maturation of microRNA is hormonally regulated by a nuclear receptor

21 January 2018

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Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing

21 January 2018

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Identification of the human DEAD-box protein p68 as a substrate of Tlk1

21 January 2018

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Bacterially expressed recombinant p68 RNA helicase is phosphorylated on serine, threonine, and tyrosine residues

21 January 2018

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Phosphorylation of p68 RNA helicase regulates RNA binding by the C-terminal domain of the protein

21 January 2018

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Phosphorylations of DEAD box p68 RNA helicase are associated with cancer development and cell proliferation

21 January 2018

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Phosphorylated p68 RNA helicase activates Snail1 transcription by promoting HDAC1 dissociation from the Snail1 promoter

21 January 2018

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SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.

21 January 2018

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Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential

21 January 2018

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Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase

21 January 2018

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ATPase/helicase activities of p68 RNA helicase are required for pre-mRNA splicing but not for assembly of the spliceosome

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FON.11.1

1 reference

24 August 2017

1 reference

PubMed ID

21345143