Disposition of metformin: variability due to polymorphisms of organic cation transporters (Q37848844)

24 August 2017

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title

Disposition of metformin: variability due to polymorphisms of organic cation transporters (English)

1 reference

24 August 2017

1 reference

Oliver Zolk

1

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PubMed ID

21366511

24 August 2017

language of work or name

English

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publication date

3 March 2011

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24 August 2017

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24 August 2017

44

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24 August 2017

2

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24 August 2017

119-129

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Consensus on infertility treatment related to polycystic ovary syndrome

24 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.

21 January 2018

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Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2010.549144

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 January 2018

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

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10-year follow-up of intensive glucose control in type 2 diabetes

21 January 2018

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Pharmacologic therapy for type 2 diabetes mellitus

21 January 2018

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Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2).

21 January 2018

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Oral antihyperglycemic therapy for type 2 diabetes: scientific review

21 January 2018

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Therapeutic comparison of metformin and sulfonylurea, alone and in various combinations. A double-blind controlled study.

21 January 2018

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Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

21 January 2018

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Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

21 January 2018

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Measurement of the renal clearance of drugs

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Pharmacokinetics of metformin after intravenous and oral administration to man

21 January 2018

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Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus

21 January 2018

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Polymorphism in human organic cation transporters and metformin action

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Mechanisms underlying saturable intestinal absorption of metformin

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Disposition of metformin (N,N-dimethylbiguanide) in man.

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Variability in renal clearance of substrates for renal transporters in chinese subjects

21 January 2018

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Estimating the contribution of genes and environment to variation in renal drug clearance

21 January 2018

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Cloning and characterization of two human polyspecific organic cation transporters

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Metformin transport by renal basolateral organic cation transporter hOCT2.

21 January 2018

1 reference

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Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.

21 January 2018

1 reference

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A human transporter protein that mediates the final excretion step for toxic organic cations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Organic cation transporter 1 polymorphisms predict the metabolic response to metformin in women with the polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Pharmacogenomics: inter-ethnic and intra-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs

21 January 2018

1 reference

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The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Identification and functional characterization of genetic variants of human organic cation transporters in a Korean population

21 January 2018

1 reference

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Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Genetic variants of the organic cation transporter 2 influence the disposition of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1

21 January 2018

1 reference

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Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms

21 January 2018

1 reference

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Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Repeat administration of drugs as a means to assess the genetic component in pharmacological variability

21 January 2018

1 reference

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Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene

21 January 2018

1 reference

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A single nucleotide polymorphism in STK11 influences insulin sensitivity and metformin efficacy in hyperinsulinemic girls with androgen excess.

21 January 2018

1 reference

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Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

SLC22A2 gene 808 G/T variant is related to plasma lactate concentration in Chinese type 2 diabetics treated with metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Current understanding of the pharmacogenomics of metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2010.549144

Metformin monotherapy for type 2 diabetes mellitus

21 January 2018

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1002/14651858.CD002966.PUB3

Identifiers

DOI

10.3109/07853890.2010.549144

1 reference

24 August 2017

1 reference

PubMed ID

21366511