Targeting the anaphase promoting complex: common pathways for viral infection and cancer therapy (Q37849772)

24 August 2017

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title

Targeting the anaphase promoting complex: common pathways for viral infection and cancer therapy (English)

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24 August 2017

Linda Smolders

1

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24 August 2017

Jose G Teodoro

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

5 March 2011

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Expert Opinion on Therapeutic Targets

24 August 2017

published in

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24 August 2017

volume

15

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24 August 2017

issue

6

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24 August 2017

page(s)

767-780

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The anaphase promoting complex/cyclosome: a machine designed to destroy

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

An architectural map of the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cdc20: a WD40 activator for a cell cycle degradation machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The APC subunit Doc1 promotes recognition of the substrate destruction box.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Securin and B-cyclin/CDK are the only essential targets of the APC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cell cycle-dependent nuclear export of Cdh1p may contribute to the inactivation of APC/C(Cdh1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Geminin, an inhibitor of DNA replication, is degraded during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Involvement of the SCF complex in the control of Cdh1 degradation in S-phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Mammalian Cdh1/Fzr mediates its own degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cdh1/Hct1-APC is essential for the survival of postmitotic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cdh1-APC controls axonal growth and patterning in the mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Independent regulation of synaptic size and activity by the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

A tumor-specific kinase activity regulates the viral death protein Apoptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Crucial roles for protein kinase C isoforms in tumor-specific killing by apoptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Adenovirus protein E4orf4 induces premature APCCdc20 activation in Saccharomyces cerevisiae by a protein phosphatase 2A-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

High-risk but not low-risk HPV E2 proteins bind to the APC activators Cdh1 and Cdc20 and cause genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Compromised spindle assembly checkpoint due to altered expression of Ubch10 and Cdc20 in human papillomavirus type 16 E6- and E7-expressing keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Human cytomegalovirus inactivates the G0/G1-APC/C ubiquitin ligase by Cdh1 dissociation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Proteasome subunits relocalize during human cytomegalovirus infection, and proteasome activity is necessary for efficient viral gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

An essential role for p73 in regulating mitotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Persistent telomere damage induces bypass of mitosis and tetraploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

CDC20, a potential cancer therapeutic target, is negatively regulated by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Strong inducible knockdown of APC/CCdc20 does not cause mitotic arrest in human somatic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Alterations of anaphase-promoting complex genes in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

An in vivo study of Cdh1/APC in breast cancer formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Dissection of the APCCdh1-Skp2 cascade in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Ras oncogenes: split personalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Profiling essential genes in human mammary cells by multiplex RNAi screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

The adenovirus E4orf4 protein induces growth arrest and mitotic catastrophe in H1299 human lung carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558008

10.1517/14728222.2011.558008

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference