Using mode of action information to improve regulatory decision-making: an ECETOC/ILSI RF/HESI workshop overview. (Q37852707)

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25 January 2020

review article

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title

Using mode of action information to improve regulatory decision-making: an ECETOC/ILSI RF/HESI workshop overview (English)

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3

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J E Doe

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author name string

Neil Carmichael

1

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Melanie Bausen

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Samuel M Cohen

4

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Michelle Embry

5

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Claudia Fruijtier-Pölloth

6

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Richard Lewis

8

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M E Bette Meek

9

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Howard Mellor

10

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Carolyn Vickers

11

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Helmut Greim

7

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language of work or name

English

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publication date

1 March 2011

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Critical Reviews in Toxicology

25 January 2020

published in

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volume

41

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issue

3

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page(s)

175-186

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Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: the National Cancer Institute Cohort

25 January 2020

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Mode of action as a determining factor in additivity models for chemical mixture risk assessment

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The role of mode of action studies in extrapolating to human risks in toxicology

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Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia

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A framework for human relevance analysis of information on carcinogenic modes of action

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Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

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Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data

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IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis

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Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers.

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Application of mode-of-action considerations in human cancer risk assessment

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The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

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Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms

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