Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals (Q37853427)

24 August 2017

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title

Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals (English)

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24 August 2017

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Brett M Paterson

1

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24 August 2017

Paul S Donnelly

series ordinal

2

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24 August 2017

language of work or name

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15 March 2011

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24 August 2017

published in

Chemical Society Reviews

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24 August 2017

volume

40

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24 August 2017

issue

5

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24 August 2017

page(s)

3005-3018

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The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.

24 August 2017

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21 January 2018

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21 January 2018

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

21 January 2018

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Combating Alzheimer's disease with multifunctional molecules designed for metal passivation

21 January 2018

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Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

21 January 2018

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Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

21 January 2018

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Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

21 January 2018

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Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity.

21 January 2018

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21 January 2018

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Copper radionuclides and radiopharmaceuticals in nuclear medicine

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Efficient production of high specific activity 64Cu using a biomedical cyclotron

21 January 2018

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Determination of the beta- branching ratio of 64Cu by mass spectrometric investigations of the decay products in neutron transmuted copper.

21 January 2018

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Mitochondria-selective reduction of 62Cu-pyruvaldehyde bis(N4-methylthiosemicarbazone) (62Cu-PTSM) in the murine brain; a novel radiopharmaceutical for brain positron emission tomography (PET) imaging

21 January 2018

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Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography.

21 January 2018

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Cu(II) bis(thiosemicarbazone) radiopharmaceutical binding to serum albumin: further definition of species dependence and associated substituent effects

21 January 2018

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Assessment of Cu-ETS as a PET radiopharmaceutical for evaluation of regional renal perfusion

21 January 2018

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Copper(II)[2,3-butanedionebis(N4-methylthiosemicarbazone)], a stable superoxide dismutase-like copper complex with high membrane penetrability

21 January 2018

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Cu-ATSM, an intracellular-accessible superoxide dismutase (SOD)-like copper complex: evaluation in an ischemia-reperfusion injury model

21 January 2018

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Exploiting tumour hypoxia in cancer treatment

21 January 2018

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Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions

21 January 2018

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

21 January 2018

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Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

21 January 2018

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Hypoxic Sensitizers — Implications for Radiation Therapy

21 January 2018

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A marker for hypoxic cells in tumours with potential clinical applicability

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0CS00215A

Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0CS00215A

Studies of 99mTc-BnAO (HL-91): a non-nitroaromatic compound for hypoxic cell detection.

21 January 2018

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An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent alpha-N-heterocyclic chalcogensemicarbazones

21 January 2018

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Studies on the mechanism of hypoxic selectivity in copper bis(thiosemicarbazone) radiopharmaceuticals.

21 January 2018

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An unusual dimeric structure of a Cu(I) bis(thiosemicarbazone) complex: implications for the mechanism of hypoxic selectivity of the Cu(II) derivatives

21 January 2018

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Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells.

21 January 2018

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Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships

21 January 2018

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Probing the mechanism of hypoxia selectivity of copper bis(thiosemicarbazonato) complexes: DFT calculation of redox potentials and absolute acidities in solution

21 January 2018

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Towards new transition metal-based hypoxic selective agents for therapy and imaging

21 January 2018

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In vitro kinetic studies on the mechanism of oxygen-dependent cellular uptake of copper radiopharmaceuticals.

21 January 2018

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Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. insights into mechanisms of copper uptake and hypoxia selectivity

21 January 2018

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Intra-tumoral distribution of (64)Cu-ATSM: a comparison study with FDG.

21 January 2018

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Double-tracer autoradiography with Cu-ATSM/FDG and immunohistochemical interpretation in four different mouse implanted tumor models.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0CS00215A

Radio-copper-labeled Cu-ATSM: an indicator of quiescent but clonogenic cells under mild hypoxia in a Lewis lung carcinoma model.

21 January 2018

1 reference

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Autoradiographic and small-animal PET comparisons between (18)F-FMISO, (18)F-FDG, (18)F-FLT and the hypoxic selective (64)Cu-ATSM in a rodent model of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Examining the relationship between Cu-ATSM hypoxia selectivity and fatty acid synthase expression in human prostate cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Fatty acid synthase, a proficient multifunctional enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Retention of the radiotracers 64Cu-ATSM and 64Cu-PTSM in human and murine tumors is influenced by MDR1 protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Cu-ATSM: a radiopharmaceutical for the PET imaging of hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): An agent for radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Basic characterization of 64Cu-ATSM as a radiotherapy agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Radiobiological effects of hypoxia-dependent uptake of 64Cu-ATSM: enhanced DNA damage and cytotoxicity in hypoxic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Internal radiotherapy with copper-64-diacetyl-bis (N4-methylthiosemicarbazone) reduces CD133+ highly tumorigenic cells and metastatic ability of mouse colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Versatile new bis(thiosemicarbazone) bifunctional chelators: synthesis, conjugation to bombesin(7-14)-NH(2), and copper-64 radiolabeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Isolation and structure of bombesin and alytesin, two analogous active peptides from the skin of the european amphibiansBombina andAlytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Pharmacology and neurochemistry of bombesin-like peptides

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0CS00215A

MicroPET imaging of a gastrin-releasing peptide receptor-positive tumor in a mouse model of human prostate cancer using a 64Cu-labeled bombesin analogue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Comparative in vitro and in vivo evaluation of two 64Cu-labeled bombesin analogs in a mouse model of human prostate adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

True radiotracers: Cu-64 targeting vectors based upon bombesin peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Copper complexes of thiosemicarbazone-pyridylhydrazine (THYNIC) hybrid ligands: a new versatile potential bifunctional chelator for copper radiopharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

[(64)Cu]diacetyl-bis(N(4)-methyl-thiosemicarbazone) - a radiotracer for tumor hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Molecular Imaging of Hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

Synergistic Interaction of Kethoxal bis(Thiosemicarbazone) and Cupric Ions in Sarcoma 180

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00215A

21 January 2018

Identifiers

DOI

10.1039/C0CS00215A

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24 August 2017

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