N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases (Q37857239)

24 August 2017

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title

N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases (English)

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24 August 2017

Sanna Kaivosaari

1

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24 August 2017

Moshe Finel

series ordinal

2

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24 August 2017

Mikko Koskinen

series ordinal

3

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24 August 2017

language of work or name

English

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publication date

24 March 2011

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24 August 2017

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24 August 2017

41

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24 August 2017

8

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24 August 2017

652-669

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The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan

24 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Acyl glucuronide reactivity in perspective: biological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Nicotine metabolism in African Americans and European Americans: variation in glucuronidation by ethnicity and UGT2B10 haplotype

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

UDP-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Glucuronidation of tobacco-specific nitrosamines by UGT2B10

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Sulfation through the looking glass--recent advances in sulfotransferase research for the curious

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Glucuronidation of amitriptyline in man in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Human sulfotransferases and their role in chemical metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Microsomal N-glucuronidation of nicotine and cotinine: human hepatic interindividual, human intertissue, and interspecies hepatic variation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Metabolism and disposition kinetics of nicotine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Characterization of afloqualone N-glucuronidation: species differences and identification of human UDP-glucuronosyltransferase isoform(s).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

UDP-Glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Glucuronidation of entacapone, nitecapone, tolcapone, and some other nitrocatechols by rat liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Regulation of UDP glucuronosyltransferase genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Drug glucuronidation in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Characterization of N-glucuronidation of 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): a new xanthine oxidoreductase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

The human UDP-glucuronosyltransferases: structural aspects and drug glucuronidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Human CYPs: in vivo and clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Species differences in UDP-glucuronosyltransferase activities in mice and rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Preclinical pharmacokinetics: an approach towards safer and efficacious drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Evaluation of the marmoset as a model species for drug glucuronidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Identification of the rabbit liver UDP-glucuronosyltransferase catalyzing the glucuronidation of 4-ethoxyphenylurea (dulcin).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles by liver microsomes: interspecies differences and structure-metabolism relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Glucuronidation and the UDP-glucuronosyltransferases in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

N-glucuronidation of perfluorooctanesulfonamide by human, rat, dog, and monkey liver microsomes and by expressed rat and human UDP-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

N-glucuronidation of the platelet-derived growth factor receptor tyrosine kinase inhibitor 6,7-(dimethoxy-2,4-dihydroindeno[1,2-C]pyrazol-3-yl)-(3-fluoro-phenyl)-amine by human UDP-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Metabolism of N-acetylbenzidine and initiation of bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Amide N-glucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.563327

10.3109/00498254.2011.563327

21 January 2018

Identifiers

DOI

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24 August 2017

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