Mitochondrial dysfunction and nicotinamide dinucleotide catabolism as mechanisms of cell death and promising targets for neuroprotection (Q37864604)

24 August 2017

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title

Mitochondrial dysfunction and nicotinamide dinucleotide catabolism as mechanisms of cell death and promising targets for neuroprotection (English)

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24 August 2017

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Tibor Kristian

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24 August 2017

Irina Balan

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2

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24 August 2017

Rosemary Schuh

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3

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24 August 2017

Mitch Onken

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4

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24 August 2017

12 April 2011

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Journal of Neuroscience Research

24 August 2017

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24 August 2017

89

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24 August 2017

12

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24 August 2017

1946-1955

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Regulation of intracellular levels of NAD: a novel role for CD38.

24 August 2017

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Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition

21 January 2018

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NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death

21 January 2018

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

21 January 2018

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Therapeutic window for nicotinamide following transient focal cerebral ischemia

21 January 2018

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Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats.

21 January 2018

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

21 January 2018

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Visualization and quantification of NAD(H) in brain sections by a novel histo-enzymatic nitrotetrazolium blue staining technique

21 January 2018

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Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

21 January 2018

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Mitochondria take center stage in aging and neurodegeneration

21 January 2018

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NAD+ metabolism in health and disease

21 January 2018

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Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism

21 January 2018

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Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

21 January 2018

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A mitochondrial perspective on cell death

21 January 2018

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Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

21 January 2018

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Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

21 January 2018

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NAD(P)H fluorescence transients after synaptic activity in brain slices: predominant role of mitochondrial function

21 January 2018

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Cell biology. PARP-1--a perpetrator of apoptotic cell death?

21 January 2018

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Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injury

21 January 2018

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The type 2 ryanodine receptor of neurosecretory PC12 cells is activated by cyclic ADP-ribose. Role of the nitric oxide/cGMP pathway.

21 January 2018

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On the involvement of mitochondrial intermembrane junctional complexes in apoptosis

21 January 2018

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Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria

21 January 2018

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Mitochondrial intermembrane junctional complexes and their involvement in cell death

21 January 2018

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Pathophysiological relevance of mitochondria in NAD(+) metabolism.

21 January 2018

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Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

21 January 2018

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Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.

21 January 2018

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Mitochondrial participation in ischemic and traumatic neural cell death

21 January 2018

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Mechanisms of neuronal death and neuroprotection

21 January 2018

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Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo

21 January 2018

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Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis

21 January 2018

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Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line

21 January 2018

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Cyclic ADP-ribose: a new way to control calcium.

21 January 2018

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Prolonged survival of transected nerve fibres in C57BL/Ola mice is an intrinsic characteristic of the axon

21 January 2018

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Bioenergetics and glutamate excitotoxicity

21 January 2018

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Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

21 January 2018

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The permeability transition pore complex: another view.

21 January 2018

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Cyclophilin D is expressed predominantly in mitochondria of gamma-aminobutyric acidergic interneurons

21 January 2018

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Neuroglia in neurodegeneration

21 January 2018

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Molecular mechanism of ADP-ribosyl cyclase activation in angiotensin II signaling in murine mesangial cells

21 January 2018

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Nicotinamide as a precursor for NAD+ prevents apoptosis in the mouse brain induced by tertiary-butylhydroperoxide

21 January 2018

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Oxidative changes in brain pyridine nucleotides and neuroprotection using nicotinamide

21 January 2018

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Nicotinamide Offers Multiple Protective Mechanisms in Stroke as a Precursor for NAD<sup>+</sup>, as a PARP Inhibitor and by Partial Restoration of Mitochondrial Function

21 January 2018

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Immunohistochemical identification of quinolinic acid phosphoribosyltransferase in glial cultures from rat brain

21 January 2018

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CD38 regulation in activated astrocytes: implications for neuroinflammation and HIV-1 brain infection

21 January 2018

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The mitochondrial permeability transition as a target for neuroprotection

21 January 2018

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Metabolic stages, mitochondria and calcium in hypoxic/ischemic brain damage

21 January 2018

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A fluorescence-based technique for screening compounds that protect against damage to brain mitochondria

21 January 2018

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Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion.

21 January 2018

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Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat.

21 January 2018

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Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction

21 January 2018

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Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons

21 January 2018

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Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity

21 January 2018

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Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology

21 January 2018

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Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress

21 January 2018

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Pathways towards and away from Alzheimer's disease

21 January 2018

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Dual role of CD38 in microglial activation and activation-induced cell death.

21 January 2018

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Delayed treatment with nicotinamide (Vitamin B(3)) improves neurological outcome and reduces infarct volume after transient focal cerebral ischemia in Wistar rats

21 January 2018

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Increased brain NAD prevents neuronal apoptosis in vivo

21 January 2018

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High cyclophilin D content of synaptic mitochondria results in increased vulnerability to permeability transition.

21 January 2018

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

21 January 2018

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Mitochondrial calcium uptake capacity as a therapeutic target in the R6/2 mouse model of Huntington's disease

21 January 2018

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Poly (ADP-ribose) polymerase, nitric oxide and cell death

21 January 2018

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Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage

21 January 2018

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Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity

21 January 2018

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Tryptophan metabolism in the central nervous system: medical implications

21 January 2018

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Nicotinamide attenuates focal ischemic brain injury in rats: with special reference to changes in nicotinamide and NAD+ levels in ischemic core and penumbra

21 January 2018

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Delayed treatment with nicotinamide (vitamin B3) reduces the infarct volume following focal cerebral ischemia in spontaneously hypertensive rats, diabetic and non-diabetic Fischer 344 rats

21 January 2018

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Perinatal hypoxic and ischemic damage to the central nervous system causes changes in the expression of connexin 43 and CD38 and ADP-ribosyl cyclase activity in brain cells.

21 January 2018

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Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

21 January 2018

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Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

21 January 2018

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Calcium-dependent spontaneously reversible remodeling of brain mitochondria.

21 January 2018

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Degradation of NAD by synaptosomes and its inhibition by nicotinamide mononucleotide: implications for the role of NAD as a synaptic modulator

21 January 2018

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Vitamin transport and homeostasis in mammalian brain: focus on Vitamins B and E.

21 January 2018

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Niacin and niacinamide accumulation by rabbit brain slices and choroid plexus in vitro

21 January 2018

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The powerhouse takes control of the cell: is the mitochondrial permeability transition a viable therapeutic target against neuronal dysfunction and death?

21 January 2018

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Mitochondrial permeability transition in CNS trauma: cause or effect of neuronal cell death?

21 January 2018

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Nicotinamide is a potent inhibitor of proinflammatory cytokines

21 January 2018

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Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death

21 January 2018

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Calcium store depletion potentiates a phosphodiesterase inhibitor- and dibutyryl cGMP-evoked calcium influx in rat pituitary GH3 cells.

21 January 2018

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Ultrastructural localization of CD38 immunoreactivity in rat brain.

21 January 2018

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Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model

21 January 2018

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Mitochondrial DNA damage and repair in neurodegenerative disorders

21 January 2018

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Decreased cADPR and increased NAD+ in the Cd38-/- mouse.

21 January 2018

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Neuronal protective role of PBEF in a mouse model of cerebral ischemia

21 January 2018

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New functions of a long-known molecule

21 January 2018

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The mitochondrial permeability transition.

21 January 2018

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Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JNR.22626

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24 August 2017

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