Harnessing the biology of IL-7 for therapeutic application (Q37867487)

24 August 2017

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title

Harnessing the biology of IL-7 for therapeutic application (English)

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24 August 2017

Crystal L Mackall

1

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24 August 2017

Terry J Fry

series ordinal

2

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24 August 2017

Ronald E Gress

series ordinal

3

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24 August 2017

publication date

1 May 2011

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Nature Reviews Immunology

24 August 2017

published in

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24 August 2017

volume

11

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24 August 2017

issue

5

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24 August 2017

page(s)

330-342

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Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells.

24 August 2017

cites work

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Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

21 January 2018

1 reference

Death and Baxes: mechanisms of lymphotrophic cytokines

21 January 2018

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Cell biology of IL-7, a key lymphotrophin

21 January 2018

1 reference

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

21 January 2018

1 reference

Molecular defects in T- and B-cell primary immunodeficiency diseases

21 January 2018

1 reference

Interleukin-7 receptor expression: intelligent design

21 January 2018

1 reference

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

21 January 2018

1 reference

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

21 January 2018

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Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

21 January 2018

1 reference

A role for thymic stromal lymphopoietin in CD4(+) T cell development

21 January 2018

1 reference

IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development

21 January 2018

1 reference

Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.

21 January 2018

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A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells

21 January 2018

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Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling

21 January 2018

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IL-7 Dependence in human B lymphopoiesis increases during progression of ontogeny from cord blood to bone marrow

21 January 2018

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IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF.

21 January 2018

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Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling.

21 January 2018

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Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

21 January 2018

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Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5.

21 January 2018

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Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

21 January 2018

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Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling

21 January 2018

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Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

21 January 2018

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TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation

21 January 2018

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Novel function for interleukin-7 in dendritic cell development.

21 January 2018

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An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells

21 January 2018

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Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development

21 January 2018

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Organogenesis of peripheral lymphoid organs.

21 January 2018

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Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.

21 January 2018

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Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.

21 January 2018

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Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut.

21 January 2018

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Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.

21 January 2018

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Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity

21 January 2018

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Lymphoid neogenesis in chronic inflammatory diseases.

21 January 2018

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A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

21 January 2018

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Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells

21 January 2018

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Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes

21 January 2018

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Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity

21 January 2018

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

21 January 2018

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Naive T cell homeostasis: from awareness of space to a sense of place

21 January 2018

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An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance

21 January 2018

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Ets-1 maintains IL-7 receptor expression in peripheral T cells

21 January 2018

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The role of IL-1beta in reduced IL-7 production by stromal and epithelial cells: a model for impaired T-cell numbers in the gut during HIV-1 infection

21 January 2018

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Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes

21 January 2018

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Hepatic interleukin-7 expression regulates T cell responses

21 January 2018

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Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

21 January 2018

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Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells

21 January 2018

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Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells

21 January 2018

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IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells

21 January 2018

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The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery

21 January 2018

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Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts

21 January 2018

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Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals.

21 January 2018

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Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

21 January 2018

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

21 January 2018

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Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count

21 January 2018

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A potential role for interleukin-7 in T-cell homeostasis

21 January 2018

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Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis

21 January 2018

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Recombinant human thrombopoietin: basic biology and evaluation of clinical studies

21 January 2018

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Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys

21 January 2018

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Interleukin-7 restores immunity in athymic T-cell-depleted hosts

21 January 2018

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Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice.

21 January 2018

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Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques

21 January 2018

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Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution

21 January 2018

1 reference

Influence of CD80, interleukin-2, and interleukin-7 expression in human renal cell carcinoma on the expansion, function, and survival of tumor-specific CTLs.

21 January 2018

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Therapeutic vaccination against metastatic carcinoma by expression-modulated and immunomodified autologous tumor cells: a first clinical phase I/II trial

21 January 2018

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IL-7 adjuvant treatment enhances long-term tumor-antigen-specific CD8+ T-cell responses after immunization with recombinant lentivector

21 January 2018

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IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

21 January 2018

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Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

21 January 2018

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Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy

21 January 2018

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Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques.

21 January 2018

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IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

21 January 2018

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IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

21 January 2018

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Reconstitution of thymic function after stem cell transplantation in humans

21 January 2018

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Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function.

21 January 2018

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A case of progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia

21 January 2018

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Interleukin-2 therapy in patients with HIV infection

21 January 2018

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Association of serum interleukin-7 levels with the development of acute graft-versus-host disease

21 January 2018

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Novel gamma-chain cytokines as candidate immune modulators in immune therapies for cancer.

21 January 2018

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Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.

21 January 2018

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Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis

21 January 2018

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Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis

21 January 2018

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Femorotibial and patellar cartilage loss in patients prior to total knee arthroplasty, heterogeneity, and correlation with alignment of the knee

21 January 2018

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Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators.

21 January 2018

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Next generation of immunotherapy for melanoma

21 January 2018

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Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin

21 January 2018

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New insights into the development of lymphoid tissues

21 January 2018

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The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3- cells, as well as macrophages

21 January 2018

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Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity

21 January 2018

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Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice

21 January 2018

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Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza

21 January 2018

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Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21.

21 January 2018

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Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22

21 January 2018

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Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin

21 January 2018

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Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense

21 January 2018

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Long-term clinical outcome of human immunodeficiency virus-infected patients with discordant immunologic and virologic responses to a protease inhibitor-containing regimen

21 January 2018

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Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study

21 January 2018

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Patients' characteristics and clinical implications of suboptimal CD4 T-cell gains after 1 year of successful antiretroviral therapy

21 January 2018

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Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

21 January 2018

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A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127

21 January 2018

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Cutting Edge: Thymic NK Cells Develop Independently from T Cell Precursors

21 January 2018

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IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates

21 January 2018

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Bax deficiency partially corrects interleukin-7 receptor alpha deficiency

31 March 2020

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IL-7-dependent B lymphocytes are essential for the anti-polysaccharide response and protective immunity to Streptococcus pneumoniae

31 March 2020

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IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway

31 March 2020

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Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells

31 March 2020

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Age-dependent incidence, time course, and consequences of thymic renewal in adults

31 March 2020

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IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation

31 March 2020

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Effects of exogenous interleukin-7 on human thymus function

31 March 2020

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Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation

31 March 2020

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Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation

31 March 2020

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Augmentation of antitumor immunity by genetically engineered fibroblast cells to express both B7.1 and interleukin-7

31 March 2020

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IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

31 March 2020

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Genetic polymorphisms in the genes encoding human interleukin-7 receptor-alpha: prognostic significance in allogeneic stem cell transplantation

31 March 2020

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Plasma levels of IL-7 and IL-15 in the first month after myeloablative BMT are predictive biomarkers of both acute GVHD and relapse

31 March 2020

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Interleukin 7 worsens graft-versus-host disease

31 March 2020

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The development of dermatitis infiltrated by gamma delta T cells in IL-7 transgenic mice

31 March 2020

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IL-7 Is essential for the development and the persistence of chronic colitis

31 March 2020

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Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis

31 March 2020

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Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure

31 March 2020

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Background to hematopoietic cell transplantation, including post transplant immune recovery

31 March 2020

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Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment

31 March 2020

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12 December 2020

Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy.

1 reference

12 December 2020

Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice

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12 December 2020

Erythropoietin: from bench to bedside.

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12 December 2020

Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool

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12 December 2020

Immunotherapeutic effects of IL-7 during a chronic viral infection in mice

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12 December 2020

Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice.

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12 December 2020

Diverse immunological and hematological effects of interleukin 7: implications for clinical application

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12 December 2020

Administration of IL-7 to mice with cyclophosphamide-induced lymphopenia accelerates lymphocyte repopulation

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12 December 2020

IL-7 activates alpha4beta1 integrin in murine thymocytes

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12 December 2020

Interleukin-7 induced immunopathology in arthritis

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12 December 2020

Levels of recombinant human granulocyte colony-stimulating factor in serum are inversely correlated with circulating neutrophil counts

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12 December 2020

Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7.

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12 December 2020

Identifiers

DOI

10.1038/NRI2970

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24 August 2017

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