The mechanistic basis for the induction of hepatic steatosis by xenobiotics (Q37867697)

24 August 2017

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title

The mechanistic basis for the induction of hepatic steatosis by xenobiotics (English)

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24 August 2017

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David E Amacher

1

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PubMed ID

21510823

24 August 2017

language of work or name

English

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publication date

21 April 2011

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Expert Opinion on Drug Metabolism & Toxicology

24 August 2017

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24 August 2017

7

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24 August 2017

8

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24 August 2017

949-965

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Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines

24 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Zonation of fatty acid metabolism in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Hormonal and nutritional regulation of SCD1 gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Regulation of hepatic gene expression by saturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

The subcellular localization of acetyl-CoA carboxylase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Insulin signaling meets mitochondria in metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

FoxO1 integrates insulin signaling to VLDL production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Carbohydrate responsive element binding protein and lipid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Membrane topology of human insig-1, a protein regulator of lipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Involvement of mammalian sirtuin 1 in the action of ethanol in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Adiponectin: a key adipokine in alcoholic fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: high frequency of involvement and rapid reversal after completion of tamoxifen therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

The role of the carnitine system in human metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Gene expression profiling in livers of mice after acute inhibition of beta-oxidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Adiponectin--a key adipokine in the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Metabolic benefits from Sirt1 and Sirt1 activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Sirtuins regulate key aspects of lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Histopathologic analysis of suspected amiodarone hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

New approaches to target microsomal triglyceride transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Investigation into the mechanism of tetracycline-induced steatosis: study in isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Decreased microsomal triglyceride transfer protein activity contributes to initiation of alcoholic liver steatosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Calcium-antagonists inhibit secretion of very-low-density lipoprotein from cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Inhibiting proteasomal degradation of microsomal triglyceride transfer protein prevents CCl4-induced steatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Effects of AMPK activators on the sub-cellular distribution of fatty acid transporters CD36 and FABPpm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Gene expression in human NAFLD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Endoplasmic reticulum stress: cell life and death decisions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Regulation of hepatic lipogenesis by the transcription factor XBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

ER chaperones in mammalian development and human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Intersection of the unfolded protein response and hepatic lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

PPAR control: it's SIRTainly as easy as PGC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Cellular fatty acid uptake: a pathway under construction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Endogenous ligand for an orphan receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

PXR and LXR in hepatic steatosis: a new dog and an old dog with new tricks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Hepatic gene expression profiling and lipid homeostasis in mice exposed to steatogenic drug, tetracycline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Gene expression profiles of murine fatty liver induced by the administration of methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Tetracycline-induced steatosis in primary canine hepatocyte cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Cytometric analysis for drug-induced steatosis in HepG2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

In vitro assay for drug-induced hepatosteatosis using rat primary hepatocytes, a fluorescent lipid analog and gene expression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Acute and chronic drug-induced hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

AMPK: Lessons from transgenic and knockout animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Biochemical effects of SIRT1 activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

The Akt-SREBP nexus: cell signaling meets lipid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

SREBP transcription factors: master regulators of lipid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Regulation of hepatic de novo lipogenesis in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

Microvesicular steatosis induced by a short chain fatty acid: effects on mitochondrial function and correlation with gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577740

10.1517/17425255.2011.577740

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21510823