Implications of genomic instability in the diagnosis and treatment of breast cancer (Q37872301)

24 August 2017

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title

Implications of genomic instability in the diagnosis and treatment of breast cancer (English)

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24 August 2017

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Emilia Wiechec

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PubMed ID

21545260

24 August 2017

language of work or name

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1 May 2011

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

24 August 2017

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24 August 2017

11

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24 August 2017

4

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24 August 2017

445-453

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Epidemiology of breast cancer.

24 August 2017

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21 January 2018

Cancer statistics, 2009

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Molecular portraits of human breast tumours

21 January 2018

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Reasons for breast cancer heterogeneity

21 January 2018

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The effect of genetic variability on drug response in conventional breast cancer treatment

21 January 2018

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The role of genetic variability in drug metabolism pathways in breast cancer prognosis

21 January 2018

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Caretaker tumour suppressor genes that defend genome integrity

21 January 2018

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Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

21 January 2018

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Cancer: the evolved consequence of a destabilized genome

21 January 2018

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

21 January 2018

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Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics

21 January 2018

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Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics

21 January 2018

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Deconstructing the molecular portraits of breast cancer

21 January 2018

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Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer

21 January 2018

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Breast cancer molecular subtypes respond differently to preoperative chemotherapy

21 January 2018

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Triple negative tumours: a critical review

21 January 2018

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Triple-negative breast cancer: clinical features and patterns of recurrence

21 January 2018

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Biology, metastatic patterns, and treatment of patients with triple-negative breast cancer

21 January 2018

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Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

21 January 2018

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Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

21 January 2018

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Complex landscapes of somatic rearrangement in human breast cancer genomes

21 January 2018

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Cellular functions of the BRCA tumour-suppressor proteins

21 January 2018

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BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications

21 January 2018

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BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

21 January 2018

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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

21 January 2018

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Iniparib plus chemotherapy in metastatic triple-negative breast cancer

21 January 2018

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Defining 'chromosomal instability'.

21 January 2018

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Cell biology: aneuploidy and cancer.

21 January 2018

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Does aneuploidy cause cancer?

21 January 2018

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Identification of aneuploidy-selective antiproliferation compounds

21 January 2018

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Telomere dysfunction, genome instability and cancer

21 January 2018

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DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line.

21 January 2018

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EBV and genomic instability--a new look at the role of the virus in the pathogenesis of Burkitt's lymphoma.

21 January 2018

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Telomeres, chromosome instability and cancer

21 January 2018

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Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancer

21 January 2018

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Loss of FHIT expression in breast cancer is correlated with poor prognostic markers.

21 January 2018

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WWOX--the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis

21 January 2018

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Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy

21 January 2018

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A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

21 January 2018

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Promoter methylation and the detection of breast cancer

21 January 2018

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Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.

21 January 2018

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Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome.

21 January 2018

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Histone modifications as markers of cancer prognosis: a cellular view.

21 January 2018

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DNA methylation epigenotypes in breast cancer molecular subtypes

21 January 2018

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Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns

21 January 2018

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Novel patterns of genome rearrangement and their association with survival in breast cancer

21 January 2018

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Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer

21 January 2018

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

21 January 2018

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Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer

21 January 2018

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The prognostic significance of determining DNA content in breast cancer by DNA image cytometry: the role of high grade aneuploidy in node negative breast cancer

21 January 2018

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Centrosome amplification and the origin of chromosomal instability in breast cancer

21 January 2018

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Identification of a human mitotic checkpoint gene: hsMAD2

21 January 2018

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Tissue microarray-based study of patients with lymph node-negative breast cancer shows that HER2/neu overexpression is an important predictive marker of poor prognosis.

21 January 2018

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Pathologic complete response to preoperative sequential doxorubicin/cyclophosphamide and single-agent taxane with or without trastuzumab in stage II/III HER2-positive breast cancer

21 January 2018

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C-myc, not HER-2/neu, can predict recurrence and mortality of patients with node-negative breast cancer

21 January 2018

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Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy

21 January 2018

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AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

21 January 2018

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AIB1 is a predictive factor for tamoxifen response in premenopausal women.

21 January 2018

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Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell lines

21 January 2018

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FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

21 January 2018

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PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.

21 January 2018

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RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients

21 January 2018

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E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer?

21 January 2018

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E-cadherin expression in primary carcinomas of the breast and its distant metastases

21 January 2018

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FHIT alterations in breast cancer

21 January 2018

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Association of allelic loss at 8p22 with poor prognosis among breast cancer cases treated with high-dose adjuvant chemotherapy

21 January 2018

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NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosis

21 January 2018

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A Recurrent Chromosome Breakpoint in Breast Cancer at theNRG1/Neuregulin 1/HeregulinGene

21 January 2018

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Cyclin D1 protein expression and function in human breast cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERM.11.21

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24 August 2017

1 reference

PubMed ID

21545260