Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators (Q37887954)

24 August 2017

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title

Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators (English)

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24 August 2017

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Hershko C

1

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24 August 2017

1 December 1994

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Best Practice and Research: Clinical Haematology

24 August 2017

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24 August 2017

7

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24 August 2017

4

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24 August 2017

965-1000

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Prevention of doxorubicin-induced myocardial and haematological toxicities in rats by the iron chelator desferrioxamine

24 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Evidence of cytosolic iron release during post-ischaemic reperfusion of isolated rat hearts. Influence on spin-trapping experiments with DMPO

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Plasmodicidal effect of desferrioxamine B in human vivax or falciparum malaria from Thailand

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Decrease of myocardial infarct size with desferrioxamine: possible role of oxygen free radicals in its ameliorative effect

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Deferoxamine and eflornithine (DL-alpha-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Antitumour Activity in a Series of bisDiketopiperazines

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Iron chelation in myocardial preservation after ischemia-reperfusion injury: the importance of pretreatment and toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Deferoxamine, cyclophosphamide, etoposide, carboplatin, and thiotepa (D-CECaT): a new cytoreductive chelation-chemotherapy regimen in patients with advanced neuroblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Prevention of doxorubicin-induced killing of MCF-7 human breast cancer cells by oxygen radical scavengers and iron chelating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Suppression of malaria infection by oxidant-sensitive host erythrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Maintenance of left ventricular function (90%) after twenty-four-hour heart preservation with deferoxamine

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Evidence for a role of iron-catalyzed oxidants in functional and metabolic stunning in the canine heart

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

14C-desferrioxamine B: uptake into erythrocytes infected with Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Plasmodium falciparum: inhibition in vitro with lactoferrin, desferriferrithiocin, and desferricrocin

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

The status of zinc in malaria (Plasmodium falciparum) infected human red blood cells: stage dependent accumulation, compartmentation and effect of dipicolinate.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Anthracycline glycoside-membrane interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Adriamycin-iron catalysed phospholipid peroxidation: a reaction not involving reduced adriamycin or hydroxyl radicals

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Reduction of vein graft intimal hyperplasia by ex vivo treatment with desferrioxamine manganese

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action?

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Oxygen toxicity, oxygen radicals, transition metals and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Effect of iron and desferoxamine on cell growth and in vitro ferritin synthesis in human hepatoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Antitumor effect of deferoxamine on human hepatocellular carcinoma growing in athymic nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Iron chelators in medicine

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Deferoxamine inhibition of malaria is independent of host iron status

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Iron-chelating therapy

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https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Effect of iron deficiency and desferrioxamine on DNA synthesis in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Modifying intracellular redox balance: an approach to improving therapeutic index

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

A study of the mechanism of action of pyridoxal isonicotinoyl hydrazone at the cellular level using reticulocytes loaded with non-heme 59Fe

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

The physiology of transferrin and transferrin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Selection of hydroxypyridin-4-ones for the treatment of iron overload using in vitro and in vivo models

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Defect of cell-mediated immunity in patients with iron-deficiency anaemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Iron availability and free radical induced injury in the isolated ischaemic/reperfused rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Deferoxamine, an iron chelator, reduces myocardial injury and free radical generation in isolated neonatal rabbit hearts subjected to global ischaemia-reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

1,2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for treatment of iron overload

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Influence of selenium on lipid peroxidation and cardiac functions in chronically adriamycin-treated rats

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Role of iron in Trypanosoma cruzi infection of mice

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Prevention of postischemic injury in immature intestine by deferoxamine

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

The antimalarial action of desferal involves a direct access route to erythrocytic (Plasmodium falciparum) parasites

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

In vivo antimalarial action of a lipophilic iron (III) chelator: suppression of Plasmodium vinckei infection by reversed siderophore.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Failure of iron chelators to protect against cerebral infarction in hypoxia-ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

NADPH- and adriamycin-dependent microsomal release of iron and lipid peroxidation.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Effects of acute iron loading on contractility and spontaneous beating rate of cultured rat myocardial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Deferoxamine attenuates ischemia-induced reperfusion injury in the skin and muscle of myocutaneous flaps in the pig

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

The adverse effect of iron repletion on the course of certain infections

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Differential effects of liposome-entrapped desferrioxamine on proliferation and erythroid differentiation of murine erythroleukemic Friend cells

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Biochemical determinants of Adriamycin toxicity in mouse liver, heart and intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Iron supplementation increases prevalence and effects of malaria: report on clinical studies in Papua New Guinea

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

The red cell and the malarial parasite

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

A reappraisal of the effects of iron and desferrioxamine on the growth of Plasmodium falciparum 'in vitro': the unimportance of serum iron.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

The effect of various chelating agents on the mobilization of iron from reticulocytes in the presence and absence of pyridoxal isonicotinoyl hydrazone

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Free radical formation by antitumor quinones

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Comparison of New Iron Chelating Agents in the Prevention of Ischemia/Reperfusion Injury: A Swine Model of Heart-Lung Transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Plasmodium falciparum: inhibition of in vitro growth by desferrioxamine.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Ribonucleotide Reductase—a Radical Enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

A protein on Plasmodium falciparum-infected erythrocytes functions as a transferrin receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Prevention of post-ischemic brain lipid conjugated diene production and neurological injury by hydroxyethyl starch-conjugated deferoxamine

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

A transferrin-independent iron uptake activity in Plasmodium falciparum-infected and uninfected erythrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Direct evidence that the hydroxyl radical plays a pathogenetic role in myocardial "stunning" in the conscious dog and demonstration that stunning can be markedly attenuated without subsequent adverse effects.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Structural requirements for anthracycline-induced cardiotoxicity and antitumor effects

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Use of allopurinol and deferoxamine in cellular protection during ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

ICRF-187 permits longer treatment with doxorubicin in women with breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Combination iron depletion therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Preliminary report on the use of desferrioxamine in the treatment ofPlasmodium falciparum malaria

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Malaria pigment and extracellular iron. Possible target for iron chelating agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

The in vitro response of human tumour cells to desferrioxamine is growth medium dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Phase I study using desferrioxamine and iron sorbitol citrate in an attempt to modulate the iron status of tumor cells to enhance doxorubicin activity

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Low molecular weight iron and the oxygen paradox in isolated rat hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Iron and susceptibility to infectious disease

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Postischemic tissue injury by iron-mediated free radical lipid peroxidation.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Malaria--resurgence, resistance, and research. (First of two parts).

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Malaria--resurgence, resistance, and research (second of two parts).

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

Bark, weeds, and iron chelators--drugs for malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

The protective activity of ICRF-187 against doxorubicin-induced cardiotoxicity in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

The anthracycline antineoplastic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0950-3536%2805%2980133-7

7 January 2021

10.1016/S0950-3536(05)80133-7

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

7881162