Dynamic modeling and analysis of cancer cellular network motifs (Q37889673)

24 August 2017

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title

Dynamic modeling and analysis of cancer cellular network motifs (English)

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24 August 2017

Mathieu Cloutier

1

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PubMed ID

21674097

24 August 2017

Edwin Wang

series ordinal

2

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24 August 2017

15 June 2011

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24 August 2017

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24 August 2017

3

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24 August 2017

7

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24 August 2017

724-732

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A map of human cancer signaling

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Principles of microRNA regulation of a human cellular signaling network

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IDH1 and IDH2 mutations in gliomas

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Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen

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Cancer: a Systems Biology disease

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Modeling cancer: integration of "omics" information in dynamic systems

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Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell

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From molecular to modular cell biology

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The control systems structures of energy metabolism

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Defining network topologies that can achieve biochemical adaptation.

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Structure and function of the feed-forward loop network motif

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A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

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Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway

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Tumour glycolysis: the many faces of HIF.

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Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

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Exact stochastic simulation of coupled chemical reactions

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Network motifs are enriched with transcription factors whose transcripts have short half-lives.

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Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival

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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

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Signaling network analysis of ubiquitin-mediated proteins suggests correlations between the 26S proteasome and tumor progression

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MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc

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A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways.

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It's a noisy business! Genetic regulation at the nanomolar scale

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Feedback loops shape cellular signals in space and time

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Cell-signalling dynamics in time and space

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Network motifs: simple building blocks of complex networks

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Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study

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Network motifs: theory and experimental approaches

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Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways

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The incoherent feedforward loop can provide fold-change detection in gene regulation

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On the attenuation and amplification of molecular noise in genetic regulatory networks

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MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals

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Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible

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Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

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Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion

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A bistable Rb-E2F switch underlies the restriction point

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Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses

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Modeling the fission yeast cell cycle: quantized cycle times in wee1- cdc25Delta mutant cells

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Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism

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Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades

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Oscillations and variability in the p53 system

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Oscillations of the p53-Akt network: implications on cell survival and death

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Another turn for p53.

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Evidence for an alternative glycolytic pathway in rapidly proliferating cells

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Oncology's energetic pipeline

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Quantitative modeling and analysis of the transforming growth factor beta signaling pathway

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Mechanism of PP2A-mediated IKK beta dephosphorylation: a systems biological approach

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An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients

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Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species.

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Stochastic modeling and simulation of the p53-MDM2/MDMX loop

21 January 2018

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Quantifying oncogenic phosphotyrosine signaling networks through systems biology

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A control analysis exploration of the role of ATP utilisation in glycolytic-flux control and glycolytic-metabolite-concentration regulation

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21 January 2018

Identifiers

DOI

10.1039/C0IB00145G

1 reference

24 August 2017

1 reference

PubMed ID

21674097