Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system (Q37897498)

25 August 2017

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title

Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system (English)

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25 August 2017

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Sara L Montgomery

1

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PubMed ID

21728035

25 August 2017

William J Bowers

series ordinal

2

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25 August 2017

5 July 2011

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25 August 2017

18

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Journal of Neuroimmune Pharmacology

inferred from page(s)

published in

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25 August 2017

7

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25 August 2017

42-59

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25 August 2017

1

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https://scigraph.springernature.com/pub.10.1007/s11481-011-9287-2

25 August 2017

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Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

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New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

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Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors

21 January 2018

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21 January 2018

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21 January 2018

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Synaptic plasticity in hippocampal CA1 neurons of mice lacking type 1 inositol-1,4,5-trisphosphate receptors.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

21 January 2018

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Microglia as a source and target of cytokines

21 January 2018

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Outside-to-inside signal through the membrane TNF-alpha induces E-selectin (CD62E) expression on activated human CD4+ T cells

21 January 2018

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21 January 2018

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Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice

21 January 2018

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TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain.

21 January 2018

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The p70 tumor necrosis factor receptor mediates cytotoxicity

21 January 2018

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Tumor necrosis factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord

21 January 2018

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Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

21 January 2018

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Tumor necrosis factor identified in multiple sclerosis brain

21 January 2018

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

21 January 2018

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Effect of corticosteroids on IL1 beta and TNF alpha release by alveolar macrophages from patients with AIDS and Pneumocystis carinii pneumonia

21 January 2018

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TNF alpha and the TNF receptor superfamily: structure-function relationship(s).

21 January 2018

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Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

21 January 2018

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Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis.

21 January 2018

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Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1.

21 January 2018

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Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

21 January 2018

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Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice

21 January 2018

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Searching for a relationship between manganese and welding and Parkinson's disease

21 January 2018

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Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin

21 January 2018

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Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination

21 January 2018

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Tumour necrosis factor-alpha impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1.

21 January 2018

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Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease

21 January 2018

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Rotenone and paraquat do not directly activate microglia or induce inflammatory cytokine release

21 January 2018

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Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

21 January 2018

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Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting

21 January 2018

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Involvement of sphingomyelinases in TNF signaling pathways

21 January 2018

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Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin

21 January 2018

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The immunopathology of multiple sclerosis: an overview

21 January 2018

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TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.

21 January 2018

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The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase

21 January 2018

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Tumor necrosis factor-alpha receptor ablation in a chronic MPTP mouse model of Parkinson's disease

21 January 2018

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Parkinson's disease: from monogenic forms to genetic susceptibility factors

21 January 2018

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Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death.

21 January 2018

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Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

21 January 2018

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Neurogenesis in the adult brain: new strategies for central nervous system diseases

21 January 2018

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Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus

21 January 2018

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Tumor necrosis factor-alpha expression in ischemic neurons.

21 January 2018

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LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.

21 January 2018

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Tumor necrosis factor-alpha and interleukin-18 modulate neuronal cell fate in embryonic neural progenitor culture

21 January 2018

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Association between tumor necrosis factor-alpha promoter polymorphism and Alzheimer's disease.

21 January 2018

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TNF ligands and receptors--a matter of life and death

21 January 2018

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Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging.

21 January 2018

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Signalling by CD95 and TNF receptors: not only life and death.

21 January 2018

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Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

21 January 2018

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Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pat

21 January 2018

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Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

21 January 2018

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TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

21 January 2018

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Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease

21 January 2018

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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

21 January 2018

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Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein.

21 January 2018

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Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques.

21 January 2018

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Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients.

21 January 2018

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Increase in level of tumor necrosis factor (TNF)-alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction.

21 January 2018

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Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides

21 January 2018

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Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue.

21 January 2018

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Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

21 January 2018

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Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization

21 January 2018

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HIV-1 infection induces differentiation of immature neural cells through autocrine tumor necrosis factor and nitric oxide production

21 January 2018

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Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons

21 January 2018

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Neurotrophic survival molecules for motoneurons: an embarrassment of riches

21 January 2018

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Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor

21 January 2018

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21 January 2018

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Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability.

21 January 2018

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Tumour necrosis factor-alpha receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab

21 January 2018

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Reassessing the amyloid cascade hypothesis of Alzheimer's disease

21 January 2018

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C/EBP beta regulation of the tumor necrosis factor alpha gene

21 January 2018

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Environmental risk factors and Parkinson's disease: a metaanalysis.

21 January 2018

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Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

21 January 2018

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CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.

21 January 2018

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A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

21 January 2018

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TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

21 January 2018

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

21 January 2018

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Role of TNF-alpha receptors in mice intoxicated with the parkinsonian toxin MPTP.

21 January 2018

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Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease

21 January 2018

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Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis.

21 January 2018

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Neurobiology and treatment of Parkinson's disease

21 January 2018

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A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease.

21 January 2018

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Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment.

21 January 2018

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Characterization of a tumor necrosis factor alpha (TNF-alpha) inhibitor: evidence of immunological cross-reactivity with the TNF receptor

21 January 2018

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Macrophage-derived tumor necrosis factor alpha, an early developmental signal for motoneuron death

21 January 2018

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Anti?tumor necrosis factor therapy abrogates autoimmune demyelination

21 January 2018

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The first decade of biologic TNF antagonists in clinical practice: lessons learned, unresolved issues and future directions

21 January 2018

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Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

21 January 2018

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TNF-alpha-induced chemokine production and apoptosis in human neural precursor cells.

21 January 2018

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Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists

21 January 2018

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Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

21 January 2018

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Alpha-synuclein in Lewy bodies

21 January 2018

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Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha1

21 January 2018

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Tumor necrosis factor-α signaling maintains the ability of cortical synapses to express synaptic scaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Synaptic scaling mediated by glial TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Isolation of a stem cell for neurons and glia from the mammalian neural crest

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Risk of Alzheimer's disease and duration of NSAID use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

A novel domain within the 55 kd TNF receptor signals cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

The development of neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Tumor necrosis factor antagonist mechanisms of action: a comprehensive review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Axonal transection in the lesions of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Activity-dependent scaling of quantal amplitude in neocortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Protective effects of NSAIDs on the development of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Tumor necrosis factor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Cerebral MRI lesions and anti-tumor necrosis factor-alpha therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Transmembrane TNF-alpha mediates "forward" and "reverse" signaling, inducing cell death or survival via the NF-kappaB pathway in Raji Burkitt lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-011-9287-2

Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology

21 January 2018

1 reference

12 December 2020

Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease

1 reference

12 December 2020

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

1 reference

12 December 2020

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.

1 reference

12 December 2020

Tumor necrosis factor gene polymorphisms in patients with sporadic Parkinson's disease

1 reference

12 December 2020

Proinflammatory cytokines in sera of elderly patients with dementia: levels in vascular injury are higher than those of mild-moderate Alzheimer's disease patients.

1 reference

12 December 2020

Anti-tumor necrosis factor alpha-associated multiple sclerosis.

1 reference

12 December 2020

Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site

1 reference

12 December 2020

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1 reference

12 December 2020

Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism.

1 reference

12 December 2020

Prostaglandin E(2) receptors, EP2 and EP4, differentially modulate TNF-alpha and IL-6 production induced by lipopolysaccharide in mouse peritoneal neutrophils

1 reference

12 December 2020

GFAP null astrocytes are a favorable substrate for neuronal survival and neurite growth

1 reference

12 December 2020

TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60

1 reference

12 December 2020

Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury

1 reference

12 December 2020

p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease

1 reference

12 December 2020

Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding

1 reference

12 December 2020

Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins

1 reference

12 December 2020

Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways.

1 reference

12 December 2020

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1 reference

12 December 2020

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors

1 reference

12 December 2020

TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group

1 reference

12 December 2020

Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation

1 reference

12 December 2020

Inflammatory processes in Alzheimer's disease

1 reference

12 December 2020

Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells

1 reference

12 December 2020

CCAAT/enhancer binding protein is involved in the expression of the tumour necrosis factor gene in human monocytes

1 reference

12 December 2020

Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.

1 reference

12 December 2020

Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians

1 reference

12 December 2020

Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively

1 reference

12 December 2020

Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2.

1 reference

12 December 2020

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations?

1 reference

12 December 2020

TNFalpha contributes to the death of NGF-dependent neurons during development

1 reference

12 December 2020

Inhibition of p75 tumor necrosis factor receptor by antisense oligonucleotides increases hypoxic injury and beta-amyloid toxicity in human neuronal cell line

1 reference

12 December 2020

Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages

1 reference

12 December 2020

Tumor necrosis factor-alpha is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction

1 reference

12 December 2020

1 reference

12 December 2020

The pathogenesis of senile plaques

1 reference

12 December 2020

Tumor necrosis factor (TNF) receptors in cellular signaling of soluble and membrane-expressed TNF.

1 reference

12 December 2020

Brain beta 2-microglobulin levels are elevated in the striatum in Parkinson's disease

1 reference

12 December 2020

Soluble and cell surface receptors for tumor necrosis factor.

1 reference

12 December 2020

TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study

1 reference

12 December 2020

10.1007/S11481-011-9287-2

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

21728035