Lipotoxicity in type 2 diabetic cardiomyopathy (Q37908843)

25 August 2017

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title

Lipotoxicity in type 2 diabetic cardiomyopathy (English)

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25 August 2017

3

Patrick Schrauwen

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author name string

Tineke van de Weijer

series ordinal

1

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PubMed ID

21803867

25 August 2017

Vera B Schrauwen-Hinderling

series ordinal

2

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25 August 2017

29 July 2011

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25 August 2017

Cardiovascular Research

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25 August 2017

92

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25 August 2017

1

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25 August 2017

10-18

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Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study.

25 August 2017

1 reference

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Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

New type of cardiomyopathy associated with diabetic glomerulosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Role of diabetes in congestive heart failure: the Framingham study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

The impact of diabetes on left ventricular filling pattern in normotensive and hypertensive adults: the Strong Heart Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Diastolic dysfunction in normotensive men with well-controlled type 2 diabetes: importance of maneuvers in echocardiographic screening for preclinical diabetic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Adiposity of the heart, revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Risk factors preceding type 2 diabetes and cardiomyopathy

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Obesity, insulin resistance and free fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Diabetic cardiomyopathy revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Prospective association between fasting NEFA and type 2 diabetes: impact of post-load glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

From chronic overnutrition to insulin resistance: the role of fat-storing capacity and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Cardiac lipid accumulation associated with diastolic dysfunction in obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Exercise-induced modulation of cardiac lipid content in healthy lean young men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Mechanism of cellular uptake of long-chain fatty acids: Do we need cellular proteins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

How proteins move lipids and lipids move proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Regulation of fatty acid transport by fatty acid translocase/CD36

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Dipyridamole alters cardiac substrate preference by inducing translocation of FAT/CD36, but not that of GLUT4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Myocardial fatty acid metabolism in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Increased FAT (fatty acid translocase)/CD36-mediated long-chain fatty acid uptake in cardiac myocytes from obese Zucker rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Fatty acid metabolism is enhanced in type 2 diabetic hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Protein-mediated fatty acid uptake: regulation by contraction, AMP-activated protein kinase, and endocrine signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Characterization of a heart-specific fatty acid transport protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Expression of genes participating in regulation of fatty acid and glucose utilization and energy metabolism in developing rat hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Properties of phosphatidate phosphohydrolase and diacylglycerol acyltransferase activities in the isolated rat heart. Effect of glucagon, ischaemia and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin-resistant rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

A murine model of isolated cardiac steatosis leads to cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Changes in mitochondrial calcium concentration during the cardiac contraction cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Lipotoxic heart disease in obese rats: implications for human obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Regulation of energy substrate metabolism in the diabetic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

The diabetic heart is more sensitive to ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

The metabolic vicious cycle in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Adaptation and maladaptation of the heart in diabetes: Part I: general concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Uncoupling proteins in human heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

ATP-dependent K(+) channels contribute to local metabolic coronary vasodilation in experimental diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Effect of fatty acids on energy coupling processes in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Membrane-linked systems preventing superoxide formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

"Mild" uncoupling of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Myocardial fatty acid oxidation in patients with impaired glucose tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Redox status and lipid peroxidation in alcoholic hypertensive patients and alcoholic hypertensive patients with diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Interrelationship of antioxidative status, lipid peroxidation, and lipid profile in insulin-dependent and non-insulin-dependent diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Diabetic Cardiomyopathy in OVE26 Mice Shows Mitochondrial ROS Production and Divergence Between In Vivo and In Vitro Contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Clinical features of myocardial triglyceride in different types of cardiomyopathy assessed by proton magnetic resonance spectroscopy: comparison with myocardial creatine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Cardiac energy metabolism homeostasis: role of cytosolic calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Insulin and inositol 1,4,5-trisphosphate trigger abnormal cytosolic Ca2+ transients and reveal mitochondrial Ca2+ handling defects in cardiomyocytes of ob/ob mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Palmitate-induced apoptosis can occur through a ceramide-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Lipid accumulation in non-adipose tissue and lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Mediators of endoplasmic reticulum stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Adiponectin improves cardiomyocyte contractile function in db/db diabetic obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

The metabolically healthy but obese individual presents a favorable inflammation profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Human epicardial adipose tissue is a source of inflammatory mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Myocardial Triglyceride Content and Epicardial Fat Mass in Human Obesity: Relationship to Left Ventricular Function and Serum Free Fatty Acid Levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Cytokines Increase Neonatal Cardiac Myocyte Calcium Concentrations: The Involvement of Nitric Oxide and Cyclic Nucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

Palmitate-mediated Alterations in the Fatty Acid Metabolism of Rat Neonatal Cardiac Myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR212

21 January 2018

Identifiers

DOI

10.1093/CVR/CVR212

1 reference

release_vxyktpkjozgd5kaugdxv2ify4u

25 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vxyktpkjozgd5kaugdxv2ify4u

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

21803867

1 reference

PubMed ID

21803867