The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus (Q37910974)

25 August 2017

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title

The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus (English)

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25 August 2017

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R S Kootte

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25 August 2017

A Vrieze

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25 August 2017

F Holleman

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25 August 2017

G M Dallinga-Thie

4

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25 August 2017

E G Zoetendal

5

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25 August 2017

W M de Vos

6

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25 August 2017

A K Groen

7

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25 August 2017

J B L Hoekstra

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25 August 2017

E S Stroes

9

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25 August 2017

M Nieuwdorp

10

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25 August 2017

22 November 2011

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Diabetes, Obesity and Metabolism

25 August 2017

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25 August 2017

14

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25 August 2017

2

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25 August 2017

112-120

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Why Is the Developed World Obese?

25 August 2017

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Global and societal implications of the diabetes epidemic

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Genetics of type 2 diabetes.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Obesity alters gut microbial ecology

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Microbiota and SCFA in lean and overweight healthy subjects

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

An obesity-associated gut microbiome with increased capacity for energy harvest

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

The gut microbiota as an environmental factor that regulates fat storage

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Diversity of the human intestinal microbial flora

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Metagenomic analysis of the human distal gut microbiome

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Development of the human infant intestinal microbiota

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Human gut microbiome: the second genome of human body

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Enterotypes of the human gut microbiome

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Getting a grip on things: how do communities of bacterial symbionts become established in our intestine?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Glycan foraging in vivo by an intestine-adapted bacterial symbiont

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Absence of intestinal microbiota does not protect mice from diet-induced obesity.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

High-fat diet determines the composition of the murine gut microbiome independently of obesity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Microbial ecology: human gut microbes associated with obesity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Production rates and metabolism of short-chain fatty acids in the colon and whole body using stable isotopes.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Colonic health: fermentation and short chain fatty acids

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Starch digestion, large-bowel fermentation and intestinal mucosal cell proliferation in rats treated with the alpha-glucosidase inhibitor acarbose

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

The role of peptide YY in integrative gut physiology and potential role in obesity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Butyrate improves insulin sensitivity and increases energy expenditure in mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Endocrine and paracrine role of bile acids

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal fibroblast growth factor 15 expression

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Regulation of sterol 12alpha-hydroxylase and cholic acid biosynthesis in the rat.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Colonization-induced host-gut microbial metabolic interaction

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

TGR5-mediated bile acid sensing controls glucose homeostasis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Human gut microbiota in obesity and after gastric bypass

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Human gut microbiome adopts an alternative state following small bowel transplantation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

High temporal and inter-individual variation detected in the human ileal microbiota.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

The bifidogenic effect of inulin and oligofructose and its consequences for gut health

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Metabolic endotoxemia initiates obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

In vivo effects of bifidobacteria and lactoferrin on gut endotoxin concentration and mucosal immunity in Balb/c mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Modulation of the human gut microflora towards improved health using prebiotics--assessment of efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Oligofructose promotes satiety in healthy human: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: an overview of enabling science and potential applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Administration of Lactobacillus casei and Lactobacillus plantarum affects the diversity of murine intestinal lactobacilli, but not the overall bacterial community structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Relative ability of orally administered Lactobacillus murinus to predominate and persist in the porcine gastrointestinal tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Differential NF-kappaB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Effects of Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

The increase of Lactobacillus species in the gut flora of newborn broiler chicks and ducks is associated with weight gain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Growth-promoting effects of single-dose intragastrically administered probiotics in chickens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Resistant starch modifies gut microflora and microbial metabolism in human flora-associated rats inoculated with faeces from Italian and UK donors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Prebiotics and synbiotics: towards the next generation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Combined use of Lactobacillus reuteri and soygerm powder as food supplement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Influence of a synbiotic mixture consisting of Lactobacillus acidophilus 74-2 and a fructooligosaccharide preparation on the microbial ecology sustained in a simulation of the human intestinal microbial ecosystem (SHIME reactor).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Long-term ecological impacts of antibiotic administration on the human intestinal microbiota

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Long-term impacts of antibiotic exposure on the human intestinal microbiota

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

The effect of oxytetracycline on insulin resistance in obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Age dependent effects of oxytetracycline in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Colonic fermentation as affected by antibiotics and acidic pH: Application of an in vitro model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Vancomycin treatment of infective endocarditis is linked with recently acquired obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Narrative review: the new epidemic of Clostridium difficile-associated enteric disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Gnotobiotic rats harboring human intestinal microbiota as a model for studying cholesterol-to-coprostanol conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Inter-species transplantation of gut microbiota from human to pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Gut microbiota: a potential new territory for drug targeting

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01483.X

10.1111/J.1463-1326.2011.01483.X

21 January 2018

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25 August 2017

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