Drug metabolism in older people--a key consideration in achieving optimal outcomes with medicines. (Q37915843)

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10 February 2020

review article

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title

Drug metabolism in older people--a key consideration in achieving optimal outcomes with medicines (English)

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10 February 2020

1

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10 February 2020

Lisa G Pont

series ordinal

2

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10 February 2020

author name string

Andrew J McLachlan

series ordinal

1

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25 August 2017

Lisa G Pont

series ordinal

2

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25 August 2017

language of work or name

English

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publication date

10 August 2011

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The Journals of Gerontology

10 February 2020

published in

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10 February 2020

volume

67

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10 February 2020

issue

2

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10 February 2020

page(s)

175-180

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Variability in response to medicines in older people: phenotypic and genotypic factors.

10 February 2020

cites work

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Drug metabolism and variability among patients in drug response

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Clinical implications of changes in hepatic drug metabolism in older people

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Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis

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The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance.

21 January 2018

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Aging biology and geriatric clinical pharmacology

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Free drug metabolic clearance in elderly people.

21 January 2018

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The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans

21 January 2018

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Liver function and phase I drug metabolism in the elderly: a paradox

21 January 2018

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Pharmacokinetics and drug metabolism in the elderly

21 January 2018

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The 'apparent clearance' of free phenytoin in elderly vs. younger adults

21 January 2018

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The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

21 January 2018

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Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

21 January 2018

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The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin

21 January 2018

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Hepatobiliary disposition of liposomal amphotericin B in the isolated perfused rat liver

21 January 2018

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21 January 2018

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Cationic drug pharmacokinetics in diseased livers determined by fibrosis index, hepatic protein content, microsomal activity, and nature of drug

21 January 2018

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Poloxamer 407 increases the recovery of paracetamol in the isolated perfused rat liver

21 January 2018

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Frailty in older adults: evidence for a phenotype

21 January 2018

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Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults

21 January 2018

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Plasma esterases and inflammation in ageing and frailty

21 January 2018

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Erythromycin breath test results in elderly, very elderly, and frail elderly persons

21 January 2018

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Outcome instruments to measure frailty: a systematic review

21 January 2018

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Validity and reliability of the Edmonton Frail Scale.

21 January 2018

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Gentamicin pharmacokinetics in old age and frailty

21 January 2018

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The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation.

21 January 2018

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Regulation of drug metabolism and disposition during inflammation and infection

21 January 2018

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The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity

21 January 2018

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Prevalence of potentially hazardous drug interactions amongst Australian veterans

21 January 2018

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The challenge of managing drug interactions in elderly people

21 January 2018

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Aging and the response to inhibition and induction of theophylline metabolism

21 January 2018

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The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity

21 January 2018

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The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics

21 January 2018

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Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib

21 January 2018

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Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: proposal for a new dosing regimen in Chinese patients

21 January 2018

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Pharmacoepigenetics: its role in interindividual differences in drug response

21 January 2018

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Pseudocapillarization and associated energy limitation in the aged rat liver

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/GERONA/GLR118

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21835808%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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