Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus (Q37921905)

25 August 2017

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title

Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus (English)

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25 August 2017

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Amalia Gastaldelli

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publication date

1 August 2011

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Diabetes Research and Clinical Practice

25 August 2017

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25 August 2017

93 Suppl 1

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25 August 2017

S60-5

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Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus

25 August 2017

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https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970015-8

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Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study

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Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis

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Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study.

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Renal gluconeogenesis: its importance in human glucose homeostasis

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Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.

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Metabolic effects of visceral fat accumulation in type 2 diabetes

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Effect of pioglitazone on the metabolic and hormonal response to a mixed meal in type II diabetes.

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Beta cell function and its relation to insulin action in humans: a critical appraisal

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beta-cell function in obesity: effects of weight loss.

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An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment.

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

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Beta- and alpha-cell dysfunction in type 2 diabetes.

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7 January 2021

Effect of exenatide on splanchnic and peripheral glucose metabolism in type 2 diabetic subjects.

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7 January 2021

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

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Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs.

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Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach

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7 January 2021

Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects

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Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply

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FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis

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Central role of the adipocyte in insulin resistance

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A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

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7 January 2021

Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients.

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7 January 2021

Hepatic insulin resistance in obese non-diabetic subjects and in type 2 diabetic patients

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7 January 2021

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

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7 January 2021

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

1 reference

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Intra-abdominal adiposity, abdominal obesity, and cardiometabolic risk

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Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity.

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Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes

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Splanchnic lipolysis in human obesity

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7 January 2021

Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes

1 reference

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7 January 2021

Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes.

1 reference

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Noninvasive quantification of pancreatic fat in humans

1 reference

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Pancreatic fat content and beta-cell function in men with and without type 2 diabetes.

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7 January 2021

beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis

1 reference

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7 January 2021

10.1016/S0168-8227(11)70015-8

Identifiers

DOI

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25 August 2017

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PubMed ID

21864753