Insights into the genetics of osteoporosis from recent genome-wide association studies (Q37922222)

25 August 2017

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title

Insights into the genetics of osteoporosis from recent genome-wide association studies (English)

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genome-wide association study

25 August 2017

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2

Timothy D Spector

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25 August 2017

Hou-Feng Zheng

1

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PubMed ID

21867596

25 August 2017

J Brent Richards

series ordinal

3

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25 August 2017

26 August 2011

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Expert Reviews in Molecular Medicine

25 August 2017

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25 August 2017

13

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25 August 2017

e28

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Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density

25 August 2017

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Common sequence variation in FLNB regulates bone structure in women in the general population and FLNB mRNA expression in osteoblasts in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Uncovering the roles of rare variants in common disease through whole-genome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Denosumab for prevention of fractures in postmenopausal women with osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Vitamin D binding protein genotype and osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Association of the aromatase gene alleles with BMD: epidemiological and functional evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Denosumab in postmenopausal women with low bone mineral density

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

The -1997 G/T and Sp1 polymorphisms in the collagen type I alpha1 (COLIA1) gene in relation to changes in femoral neck bone mineral density and the risk of fracture in the elderly: the Rotterdam study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Common and rare variants in multifactorial susceptibility to common diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

A genome-screen of a large twin cohort reveals linkage for quantitative ultrasound of the calcaneus to 2q33-37 and 4q12-21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

The transcription factors L-Sox5 and Sox6 are essential for cartilage formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Sex-specific quantitative trait loci contribute to normal variation in bone structure at the proximal femur in men

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Segregation analysis and variance components analysis of bone mineral density in healthy families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genetic factors in determining bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

The genetics of proximal femur geometry, distribution of bone mass and bone mineral density.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Linkage of osteoporosis to chromosome 20p12 and association to BMP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Effect of environmental factors and gender on the heritability of bone mineral density and bone size.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Effect of hormone replacement, alendronate, or combination therapy on hip structural geometry: a 3-year, double-blind, placebo-controlled clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

ALDH2 polymorphisms and bone mineral density in an elderly Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Ethanol and acetaldehyde inhibit the formation of early osteoblast progenitors in murine and human bone marrow cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genome-wide association study for femoral neck bone geometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Multiple genetic loci for bone mineral density and fractures

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genome-wide association with bone mass and geometry in the Framingham Heart Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

The road to genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Finding the missing heritability of complex diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genomewide association studies and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Association analysis of WNT10B with bone mass and structure among individuals of African ancestry

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Vitamin D Receptor 3′ Haplotypes Are Unequally Expressed in Primary Human Bone Cells and Associated With Increased Fracture Risk: The MrOS Study in Sweden and Hong Kong

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genetic polymorphisms of OPG, RANK, and ESR1 and bone mineral density in Korean postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Lack of association between the SOST gene and bone mineral density in perimenopausal women: analysis of five polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Further genetic evidence suggesting a role for the RhoGTPase-RhoGEF pathway in osteoporosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Parathyroid hormone stimulates expression of the Notch ligand Jagged1 in osteoblastic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

New sequence variants associated with bone mineral density

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Common variants in the region around Osterix are associated with bone mineral density and growth in childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Prediction of incident hip fracture risk by femur geometry variables measured by hip structural analysis in the study of osteoporotic fractures

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Impact of genetics on low bone mass in adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4q

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

Association of the VDR Translation Start Site Polymorphism and Fracture Risk in Older Women

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

MTHFR polymorphism and bone mineral density: meta-analysis of published studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Association of estrogen receptor dinucleotide repeat polymorphism with osteoporosis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Polymorphisms and haplotypes of integrinalpha1 (ITGA1) are associated with bone mineral density and fracture risk in postmenopausal Koreans

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Prediction of perimenopausal fractures by bone mineral density and other risk factors

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Nature, nurture and human disease

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Heritable and life-style determinants of bone mineral density

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Variance component linkage analysis indicates a QTL for femoral neck bone mineral density on chromosome 1p36

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Estrogen receptor alpha CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Effects of teriparatide [rhPTH (1-34)] treatment on structural geometry of the proximal femur in elderly osteoporotic women

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

Genes, environment, health, and disease: facing up to complexity

1 reference

https://api.crossref.org/works/10.1017%2FS1462399411001980

7 January 2021

10.1017/S1462399411001980

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

21867596