Lgr5 and Lgr6 as markers to study adult stem cell roles in self-renewal and cancer (Q37946232)

25 August 2017

Lgr5 and Lgr6 as markers to study adult stem cell roles in self-renewal and cancer (English)

1 reference

25 August 2017

M Leushacke

1

1 reference

25 August 2017

N Barker

series ordinal

2

1 reference

25 August 2017

language of work or name

English

0 references

publication date

17 October 2011

1 reference

25 August 2017

1 reference

25 August 2017

31

1 reference

25 August 2017

3009-3022

1 reference

25 August 2017

25

1 reference

https://scigraph.springernature.com/pub.10.1038/onc.2011.479

25 August 2017

0 references

cites work

Tissue-resident adult stem cell populations of rapidly self-renewing organs

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Crypt stem cells as the cells-of-origin of intestinal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

21 January 2018

The intestinal stem cell

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Identification of stem cells in small intestine and colon by marker gene Lgr5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The stem-cell zone of the small intestinal epithelium. III. Evidence from columnar, enteroendocrine, and mucous cells in the adult mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Multipotential stem cells in adult mouse gastric epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Mutation selection and the natural history of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The cancer stem cell: premises, promises and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Peptide growth factors in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

A genetic model for colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Effects of telomerase and telomere length on epidermal stem cell behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The tortoise and the hair: slow-cycling cells in the stem cell race

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

More than one way to skin . .

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Male and female Drosophila germline stem cells: two versions of immortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

A two-step mechanism for stem cell activation during hair regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The birth of therapy with cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Lineage commitment and maturation of epithelial cells in the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Mitogenic influence of human R-spondin1 on the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Coexistence of quiescent and active adult stem cells in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Stem cell niche: structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Gastrointestinal stem cells in self-renewal and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Intestinal stem cell replacement follows a pattern of neutral drift

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The intestinal epithelial stem cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Capturing and profiling adult hair follicle stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

APC mutations occur early during colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Identification and expansion of human colon-cancer-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Stabilization of beta-catenin by genetic defects in melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Live and let die in the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Signaling pathways in intestinal development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Bmi1 is expressed in vivo in intestinal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Top-down morphogenesis of colorectal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Tracking adult stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Generalized lacZ expression with the ROSA26 Cre reporter strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Defining the epithelial stem cell niche in skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Stem cells, self-renewal, and differentiation in the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The Intestinal Wnt/TCF Signature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Transcription factor achaete scute-like 2 controls intestinal stem cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Wnt signalling induces maturation of Paneth cells in intestinal crypts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Cells of origin in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Stem cells and their implications for colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Extreme sensitivity of some intestinal crypt cells to X and gamma irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Tumor growth need not be driven by rare cancer stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Identification of genes required for cytoplasmic localization in early C. elegans embryos

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

The constant renewal of the intestinal epithelium in the albino rat

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Morphogenesis and renewal of hair follicles from adult multipotent stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Location of stem cells of human hair follicles by clonal analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Significance of Lgr5(+ve) cancer stem cells in the colon and rectum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

Involvement of follicular stem cells in forming not only the follicle but also the epidermis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.479

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.479

1 reference

Dimensions Publication ID

25 August 2017

0 references

1 reference