Common cellular and molecular mechanisms in obesity and drug addiction (Q37947411)

25 August 2017

Common cellular and molecular mechanisms in obesity and drug addiction (English)

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25 August 2017

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Paul J Kenny

1

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PubMed ID

22011680

25 August 2017

language of work or name

English

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publication date

20 October 2011

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Nature Reviews Neuroscience

25 August 2017

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25 August 2017

12

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25 August 2017

638-651

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25 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrn3105

25 August 2017

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Activation of hindbrain neurons in response to gastrointestinal lipid is attenuated by high fat, high energy diets in mice prone to diet-induced obesity

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Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence

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Nicotine suppression of gustatory responses of neurons in the nucleus of the solitary tract

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Differentiating the rapid actions of cocaine

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Critical role of peripheral actions of intravenous nicotine in mediating its central effects.

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Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward

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Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion

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Activation in extended amygdala corresponds to altered hedonic processing during protracted morphine withdrawal

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Olfactory and visceral projections to the nucleus of the solitary tract.

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Weight loss associated with vagus nerve stimulation

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Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry

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Alcohol abuse and dependence before and after bariatric surgery: a review of the literature and report of a new data set.

31 March 2020

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Induction of c-Fos and DeltaFosB immunoreactivity in rat brain by Vagal nerve stimulation.

31 March 2020

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Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal.

31 March 2020

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Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins

31 March 2020

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Regulation of gene expression and cocaine reward by CREB and ΔFosB

31 March 2020

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Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids.

31 March 2020

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Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity

31 March 2020

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The Physiology of Glucagon-like Peptide 1

31 March 2020

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A role for glucagon-like peptide-1 in the central regulation of feeding

31 March 2020

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Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling

31 March 2020

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Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function.

31 March 2020

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Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation

31 March 2020

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Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats

31 March 2020

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Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food

31 March 2020

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Insular cortex and consummatory successive negative contrast in the rat.

31 March 2020

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Excitotoxic lesions of the gustatory thalamus spare simultaneous contrast effects but eliminate anticipatory negative contrast: evidence against a memory deficit

31 March 2020

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Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study

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Youth at risk for obesity show greater activation of striatal and somatosensory regions to food

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Neural substrates of abstinence-induced cigarette cravings in chronic smokers

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Damage to the insula disrupts addiction to cigarette smoking

31 March 2020

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Insular hypocretin transmission regulates nicotine reward

31 March 2020

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Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium

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Long-lasting dysregulation of gene expression in corticostriatal circuits after repeated cocaine treatment in adult rats: effects on zif 268 and homer 1a.

31 March 2020

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Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression

31 March 2020

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Increased histone acetyltransferase and lysine acetyltransferase activity and biphasic activation of the ERK/RSK cascade in insular cortex during novel taste learning.

31 March 2020

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Metabotropic glutamate receptor 5 in conditioned taste aversion learning

31 March 2020

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Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat.

31 March 2020

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Functional neuroimaging of umami taste: what makes umami pleasant?

31 March 2020

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Thought for food: imagined consumption reduces actual consumption.

31 March 2020

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Emotion, cognition, and mental state representation in amygdala and prefrontal cortex

31 March 2020

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Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors

31 March 2020

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Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia

31 March 2020

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Induction of hyperphagia and carbohydrate intake by μ-opioid receptor stimulation in circumscribed regions of frontal cortex

31 March 2020

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Role of the orbitofrontal cortex and dorsal striatum in regulating the dose-related effects of self-administered cocaine

31 March 2020

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The role of the orbitofrontal cortex in the pursuit of happiness and more specific rewards

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Lesions of the orbitofrontal but not medial prefrontal cortex disrupt conditioned reinforcement in primates.

31 March 2020

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The effects of selective orbitofrontal cortex lesions on the acquisition and performance of cue-controlled cocaine seeking in rats.

31 March 2020

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Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments.

31 March 2020

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Progression of cellular adaptations in medial prefrontal and orbitofrontal cortex in response to repeated amphetamine

31 March 2020

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The role of orbitofrontal cortex in drug addiction: a review of preclinical studies

31 March 2020

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DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction.

31 March 2020

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Increased impulsivity during withdrawal from cocaine self-administration: role for DeltaFosB in the orbitofrontal cortex

31 March 2020

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Post-ingestive positive controls of ingestive behavior

31 March 2020

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Nutrient selection in the absence of taste receptor signaling.

31 March 2020

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Food reward in the absence of taste receptor signaling

31 March 2020

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A transient receptor potential channel expressed in taste receptor cells

31 March 2020

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Nicotine activates TRPM5-dependent and independent taste pathways

31 March 2020

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Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models.

31 March 2020

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Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesity.

31 March 2020

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D1 dopamine receptors modulate deltaFosB induction in rat striatum after intermittent morphine administration

31 March 2020

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Review. Transcriptional mechanisms of addiction: role of DeltaFosB

31 March 2020

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Early life exposure to a high fat diet promotes long-term changes in dietary preferences and central reward signaling

31 March 2020

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"Snacking" causes long term attenuation of HPA axis stress responses and enhancement of brain FosB/deltaFosB expression in rats

31 March 2020

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The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior

31 March 2020

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Decreases in dietary preference produce increased emotionality and risk for dietary relapse

31 March 2020

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Food restriction enhances peak corticosterone levels, cocaine-induced locomotor activity, and DeltaFosB expression in the nucleus accumbens of the rat.

31 March 2020

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DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation.

31 March 2020

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Delta FosB-mediated alterations in dopamine signaling are normalized by a palatable high-fat diet

31 March 2020

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Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.

31 March 2020

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Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum

31 March 2020

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Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine

31 March 2020

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Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability

31 March 2020

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Neuroscience. A kinase to dampen the effects of cocaine?

31 March 2020

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A phosphatase cascade by which rewarding stimuli control nucleosomal response

31 March 2020

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Immunohistochemical localization of a melanin concentrating hormone-like peptide in the rat brain.

31 March 2020

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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

31 March 2020

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A role for melanin-concentrating hormone in the central regulation of feeding behaviour

31 March 2020

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Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.

31 March 2020

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The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance.

31 March 2020

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Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone.

31 March 2020

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The melanin-concentrating hormone system modulates cocaine reward

31 March 2020

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Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens

31 March 2020

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Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area

31 March 2020

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Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity

31 March 2020

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Ghrelin directly targets the ventral tegmental area to increase food motivation.

31 March 2020

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Leptin regulates striatal regions and human eating behavior

31 March 2020

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Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat.

31 March 2020

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Leptin regulation of the mesoaccumbens dopamine pathway.

31 March 2020

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Leptin receptor signaling in midbrain dopamine neurons regulates feeding

31 March 2020

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The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling

31 March 2020

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Effects of insulin and leptin in the ventral tegmental area and arcuate hypothalamic nucleus on food intake and brain reward function in female rats

31 March 2020

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Leptin regulates energy balance and motivation through action at distinct neural circuits

31 March 2020

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Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

31 March 2020

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Influence of cocaine on the JAK-STAT pathway in the mesolimbic dopamine system.

31 March 2020

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Characterization and Regulation of Insulin Receptors in Rat Brain

31 March 2020

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Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in rats

31 March 2020

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Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis

31 March 2020

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Effects of diabetes on methamphetamine-induced place preference in mice.

31 March 2020

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Diabetes decreases limbic extracellular dopamine in rats

31 March 2020

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Brain-derived neurotrophic factor regulates hedonic feeding by acting on the mesolimbic dopamine system

31 March 2020

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Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin

31 March 2020

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Decreased vesicular somatodendritic dopamine stores in leptin-deficient mice

31 March 2020

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Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine.

31 March 2020

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IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates.

31 March 2020

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Insulin modulates cocaine-sensitive monoamine transporter function and impulsive behavior

31 March 2020

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High impulsivity predicts the switch to compulsive cocaine-taking

31 March 2020

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The neurobiology and genetics of impulse control disorders: relationships to drug addictions

31 March 2020

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Nucleus accumbens core mammalian target of rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats.

31 March 2020

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Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

31 March 2020

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Transition to addiction is associated with a persistent impairment in synaptic plasticity

31 March 2020

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Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals.

31 March 2020

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Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.

31 March 2020

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Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission.

31 March 2020

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Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

31 March 2020

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Caspase signalling controls microglia activation and neurotoxicity.

31 March 2020

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Activation of striatal inflammatory mediators and caspase-3 is central to haloperidol-induced orofacial dyskinesia

31 March 2020

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Inflammation and metabolic disorders

31 March 2020

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Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

31 March 2020

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MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

31 March 2020

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Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB.

31 March 2020

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Obesity-mediated inflammation may damage the brain circuit that regulates food intake

31 March 2020

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Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.

31 March 2020

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Induction of nuclear factor-kappaB in nucleus accumbens by chronic cocaine administration

31 March 2020

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Induction of innate immune genes in brain create the neurobiology of addiction

31 March 2020

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

31 March 2020

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SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity

31 March 2020

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Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins

31 March 2020

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Obesity and metabolic syndrome in circadian Clock mutant mice

31 March 2020

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Regulation of dopaminergic transmission and cocaine reward by the Clock gene

31 March 2020

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Regulation of serotonin-2C receptor G-protein coupling by RNA editing

31 March 2020

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The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C

31 March 2020

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Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster

31 March 2020

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Striatal microRNA controls cocaine intake through CREB signalling

31 March 2020

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A role for central nervous system PPAR-γ in the regulation of energy balance

31 March 2020

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Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones

31 March 2020

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Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking.

31 March 2020

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Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction

31 March 2020

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Elimination of adult-born neurons in the olfactory bulb is promoted during the postprandial period

31 March 2020

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Nicotine decreases food intake through activation of POMC neurons

31 March 2020

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Overexpression of Fto leads to increased food intake and results in obesity

31 March 2020

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Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes

31 March 2020

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Chronic high-fat diet drives postnatal epigenetic regulation of μ-opioid receptor in the brain

31 March 2020

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Maternal high-fat diet effects on third-generation female body size via the paternal lineage

31 March 2020

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Chronic stress and obesity: a new view of "comfort food"

31 March 2020

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CRF system recruitment mediates dark side of compulsive eating

31 March 2020

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The role of CRF and CRF-related peptides in the dark side of addiction

31 March 2020

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Effects of high- and low-energy meals on hunger, physiological processes and reactions to emotional stress.

31 March 2020

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Motivation for palatable food despite consequences in an animal model of binge eating

31 March 2020

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A new animal model of binge eating: key synergistic role of past caloric restriction and stress.

31 March 2020

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Magnetically induced vagus nerve stimulation and feeding behavior in rats

31 March 2020

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12 December 2020

Reduced sensitivity to the satiation effect of intestinal oleate in rats adapted to high-fat diet

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12 December 2020

Neural basis of reward and craving--a homeostatic point of view.

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12 December 2020

Gene regulation through RNA editing

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12 December 2020

The obese brain: association of body mass index and insulin sensitivity with resting state network functional connectivity.

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12 December 2020

Perception of sweet taste is important for voluntary alcohol consumption in mice.

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12 December 2020

Identifiers

DOI

10.1038/NRN3105

1 reference

PubMed ID

22011680

Dimensions Publication ID

25 August 2017

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1 reference

PubMed ID

22011680