The N-end rule pathway: emerging functions and molecular principles of substrate recognition (Q37947993)

25 August 2017

The N-end rule pathway: emerging functions and molecular principles of substrate recognition (English)

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25 August 2017

Shashikanth M Sriram

1

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25 August 2017

Bo Yeon Kim

series ordinal

2

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25 August 2017

Yong Tae Kwon

series ordinal

3

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25 August 2017

21 October 2011

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Nature Reviews Molecular Cell Biology

25 August 2017

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25 August 2017

12

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25 August 2017

735-747

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25 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrm3217

25 August 2017

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cites work

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The mammalian N-end rule pathway: new insights into its components and physiological roles

31 March 2020

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The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development

31 March 2020

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PRT1 of Arabidopsis thaliana encodes a component of the plant N-end rule pathway

31 March 2020

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PRT1 of Arabidopsis Is a Ubiquitin Protein Ligase of the Plant N-End Rule Pathway with Specificity for Aromatic Amino-Terminal Residues

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The N-end rule in bacteria.

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The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat

31 March 2020

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The degradation signal in a short-lived protein

31 March 2020

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Diversity of degradation signals in the ubiquitin-proteasome system

31 March 2020

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An unstructured initiation site is required for efficient proteasome-mediated degradation

31 March 2020

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Degradation signals in the lysine-asparagine sequence space

31 March 2020

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Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway

31 March 2020

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Binding of phenylarsenoxide to Arg-tRNA protein transferase is independent of vicinal thiols

31 March 2020

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The recognition component of the N-end rule pathway

31 March 2020

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The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme

31 March 2020

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The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor

31 March 2020

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Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain

31 March 2020

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A recognition component of the ubiquitin system is required for peptide transport in Saccharomyces cerevisiae.

31 March 2020

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Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway

31 March 2020

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Degradation of G alpha by the N-end rule pathway

31 March 2020

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Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

31 March 2020

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Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.

31 March 2020

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Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

31 March 2020

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A mouse amidase specific for N-terminal asparagine. The gene, the enzyme, and their function in the N-end rule pathway

31 March 2020

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Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway

31 March 2020

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Glutamine-specific N-terminal amidase, a component of the N-end rule pathway

31 March 2020

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Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms

31 March 2020

1 reference

Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway

31 March 2020

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Identification of mammalian arginyltransferases that modify a specific subset of protein substrates

31 March 2020

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Role of arginine-tRNA in protein degradation by the ubiquitin pathway

31 March 2020

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The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators

31 March 2020

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An essential role of N-terminal arginylation in cardiovascular development

31 March 2020

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RGS4 and RGS5 are in vivo substrates of the N-end rule pathway

31 March 2020

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The mouse and human genes encoding the recognition component of the N-end rule pathway

31 March 2020

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Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway

31 March 2020

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Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway

31 March 2020

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A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons

31 March 2020

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Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases

31 March 2020

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Structural basis of substrate recognition and specificity in the N-end rule pathway

31 March 2020

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The molecular principles of N-end rule recognition.

31 March 2020

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The substrate recognition domains of the N-end rule pathway

31 March 2020

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Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway

31 March 2020

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Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems

31 March 2020

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Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role

31 March 2020

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UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

31 March 2020

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The plant N-end rule pathway: structure and functions

31 March 2020

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PRT6/At5g02310 encodes an Arabidopsis ubiquitin ligase of the N-end rule pathway with arginine specificity and is not the CER3 locus.

31 March 2020

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Clp protease complexes from photosynthetic and non-photosynthetic plastids and mitochondria of plants, their predicted three-dimensional structures, and functional implications.

31 March 2020

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Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli

31 March 2020

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Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase

31 March 2020

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ClpS is an essential component of the N-end rule pathway in Escherichia coli.

31 March 2020

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Molecular basis of substrate selection by the N-end rule adaptor protein ClpS

31 March 2020

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ClpS is the recognition component for Escherichia coli substrates of the N-end rule degradation pathway.

31 March 2020

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A proteolytic pathway that recognizes ubiquitin as a degradation signal

31 March 2020

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A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

31 March 2020

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The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

31 March 2020

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The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway

31 March 2020

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Detecting and measuring cotranslational protein degradation in vivo

31 March 2020

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SnapShot: key numbers in biology

31 March 2020

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The Molecular Basis of N-End Rule Recognition

31 March 2020

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Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA

31 March 2020

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Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS

31 March 2020

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Tuning the strength of a bacterial N-end rule degradation signal

31 March 2020

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ClpS, a substrate modulator of the ClpAP machine

31 March 2020

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The bacterial N-end rule pathway: expect the unexpected

31 March 2020

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Crystal structure of the heterodimeric complex of the adaptor, ClpS, with the N-domain of the AAA+ chaperone, ClpA

31 March 2020

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The N-end rule at atomic resolution

31 March 2020

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Towards a functional understanding of protein N-terminal acetylation

31 March 2020

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N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum

31 March 2020

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The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides

31 March 2020

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N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins

31 March 2020

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The proteomics of N-terminal methionine cleavage.

31 March 2020

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Isolation of acetylpeptide from enzymic digests of TMV-protein

31 March 2020

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Acetylation of protein N-terminal amino groups structural observations on α-amino acetylated proteins

31 March 2020

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Structures of N-terminally acetylated proteins

31 March 2020

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Degradation of proteins with acetylated amino termini by the ubiquitin system

31 March 2020

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N-terminal acetylation of cellular proteins creates specific degradation signals

31 March 2020

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Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase

31 March 2020

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Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways

31 March 2020

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A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

31 March 2020

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One step at a time: endoplasmic reticulum-associated degradation

31 March 2020

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Cotranslational processing and protein turnover in eukaryotic cells

31 March 2020

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Transgenic Galphaq overexpression induces cardiac contractile failure in mice

31 March 2020

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Vascular normalization in Rgs5-deficient tumours promotes immune destruction

31 March 2020

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Protein arginylation in rat brain cytosol: a proteomic analysis

31 March 2020

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Arginylation of beta-actin regulates actin cytoskeleton and cell motility

31 March 2020

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Global analysis of posttranslational protein arginylation

31 March 2020

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Post-translational processing of the amino terminus affects actin function

31 March 2020

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Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function.

31 March 2020

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Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation

31 March 2020

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Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability

31 March 2020

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Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

31 March 2020

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Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

31 March 2020

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Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.

31 March 2020

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The proteome of Saccharomyces cerevisiae mitochondria

31 March 2020

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Cleavage-site motifs in mitochondrial targeting peptides

31 March 2020

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Translocation of proteins into mitochondria

31 March 2020

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Mitochondrial processing peptidases

31 March 2020

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Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability

31 March 2020

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Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization

31 March 2020

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Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinol-cytochrome c reductase

31 March 2020

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Survey of amino-terminal proteolytic cleavage sites in mitochondrial precursor proteins: leader peptides cleaved by two matrix proteases share a three-amino acid motif

31 March 2020

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Post-translational arginylation of calreticulin: a new isospecies of calreticulin component of stress granules

31 March 2020

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Calcium, a signaling molecule in the endoplasmic reticulum?

31 March 2020

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The arginylation-dependent association of calreticulin with stress granules is regulated by calcium

31 March 2020

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A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent

31 March 2020

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Degradation of HIV-1 integrase by the N-end rule pathway

31 March 2020

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Sindbis virus RNA polymerase is degraded by the N-end rule pathway

31 March 2020

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Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway

31 March 2020

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Multivalency-assisted control of intracellular signaling pathways: application for ubiquitin- dependent N-end rule pathway

31 March 2020

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Partners in crime: ubiquitin-mediated degradation and autophagy

31 March 2020

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Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen

31 March 2020

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The calpain system and cancer.

31 March 2020

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The N-end rule and regulation of apoptosis

31 March 2020

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γ 2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate

31 March 2020

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RGS4 is arginylated and degraded by the N-end rule pathway in vitro

31 March 2020

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Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway

31 March 2020

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Universality and structure of the N-end rule

31 March 2020

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12 December 2020

A SOLUBLE AMINO ACID-INCORPORATING SYSTEM FROM RAT LIVER

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12 December 2020

NH2-terminal processing of Drosophila melanogaster actin. Sequential removal of two amino acids.

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12 December 2020

Ubiquitin as a degradation signal

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12 December 2020

Repair of DNA containing O6-alkylguanine

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12 December 2020

Alternate pathways for removal of the class II actin initiator methionine.

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12 December 2020

Isolation and characterization of the methionine aminopeptidase from porcine liver responsible for the co-translational processing of proteins

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12 December 2020

Identification of N-acetylmethionine as the product released during the NH2-terminal processing of a pseudo-class I actin

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12 December 2020

Enzymatic modification of proteins. VII. Substrate specificity of leucyl,phenylalanyl-transfer ribonucleic acid-protein transferase.

1 reference

12 December 2020

Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of Saccharomyces cerevisiae

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12 December 2020

Identifiers

DOI

10.1038/NRM3217

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Dimensions Publication ID

25 August 2017

1023284906

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Fatcat ID

release_aitddq7igbbffomxfuwrcpzvem

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Fatcat

https://api.fatcat.wiki/v0/release/aitddq7igbbffomxfuwrcpzvem

24 November 2022

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